Use of botulinum toxin for the treatment of keloid scars: scoping review
Introduction: Visible scars can cause problems, whether aesthetic, psychological, functional, or social, mainly of great extension and volume, such as keloids. The discovery of new treatments for keloids is not easy, given the presence of some methodological and ethical obstacles, and it is an area...
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| Format: | Article |
| Language: | English |
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Thieme Revinter Publicações Ltda.
2024-04-01
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| Series: | Revista Brasileira de Cirurgia Plástica |
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| Online Access: | http://www.rbcp.org.br/export-pdf/3416/1983-5175-rbcp-39-01-e0841-en.pdf |
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| _version_ | 1849251132447129600 |
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| author | Eduardo Lafayette Monteiro Karine Lorena Sousa Queiroz Thiago Alexandre Macedo de Azevedo |
| author_facet | Eduardo Lafayette Monteiro Karine Lorena Sousa Queiroz Thiago Alexandre Macedo de Azevedo |
| author_sort | Eduardo Lafayette Monteiro |
| collection | DOAJ |
| description | Introduction: Visible scars can cause problems, whether aesthetic, psychological, functional, or social, mainly of great extension and volume, such as keloids. The discovery of new treatments for keloids is not easy, given the presence of some methodological and ethical obstacles, and it is an area that is little explored. Botulinum toxin has been presented as a therapeutic alternative in national and international studies, requiring a compilation and highlighting of the main studies that can support clinical practice. Thus, the objective was to present a scoping review on the therapeutic use of botulinum toxin for the treatment of keloid scars.
Method: The review was carried out using the PICO strategy and using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews. It was carried out in the PubMed/Medline, Virtual Health Library, and SciELO databases, considering studies from 2016 to September 2021.
Results: Overall, 34 articles related to the topic were found. After filtering and selection, the review was constructed with the support of 5 articles. The studies varied between cohorts, case reports, randomized clinical trials, and case-control. It was possible to observe as main results of the short-term action of botulinum toxin in reducing keloids, greater effectiveness in reducing symptoms, and possibilities of clinical use for different populations and clinical manifestations.
Conclusion: The mechanism of action of botulinum toxin can facilitate the treatment of keloids and reduce symptoms, requiring more robust studies to define effective scar management protocols. |
| format | Article |
| id | doaj-art-7a1fea1027194df796c651940b661269 |
| institution | Kabale University |
| issn | 1983-5175 2177-1235 |
| language | English |
| publishDate | 2024-04-01 |
| publisher | Thieme Revinter Publicações Ltda. |
| record_format | Article |
| series | Revista Brasileira de Cirurgia Plástica |
| spelling | doaj-art-7a1fea1027194df796c651940b6612692025-08-20T03:57:03ZengThieme Revinter Publicações Ltda.Revista Brasileira de Cirurgia Plástica1983-51752177-12352024-04-0139110.5935/2177-1235.2024RBCP0841-ENUse of botulinum toxin for the treatment of keloid scars: scoping reviewEduardo Lafayette Monteiro0Karine Lorena Sousa Queiroz1Thiago Alexandre Macedo de Azevedo2Universidade Estadual do Ceará, Fortaleza, Ceará, BrazilUniversidade Estadual do Ceará, Fortaleza, Ceará, BrazilSanta Casa de Santos, Santos, São Paulo, BrazilIntroduction: Visible scars can cause problems, whether aesthetic, psychological, functional, or social, mainly of great extension and volume, such as keloids. The discovery of new treatments for keloids is not easy, given the presence of some methodological and ethical obstacles, and it is an area that is little explored. Botulinum toxin has been presented as a therapeutic alternative in national and international studies, requiring a compilation and highlighting of the main studies that can support clinical practice. Thus, the objective was to present a scoping review on the therapeutic use of botulinum toxin for the treatment of keloid scars. Method: The review was carried out using the PICO strategy and using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews. It was carried out in the PubMed/Medline, Virtual Health Library, and SciELO databases, considering studies from 2016 to September 2021. Results: Overall, 34 articles related to the topic were found. After filtering and selection, the review was constructed with the support of 5 articles. The studies varied between cohorts, case reports, randomized clinical trials, and case-control. It was possible to observe as main results of the short-term action of botulinum toxin in reducing keloids, greater effectiveness in reducing symptoms, and possibilities of clinical use for different populations and clinical manifestations. Conclusion: The mechanism of action of botulinum toxin can facilitate the treatment of keloids and reduce symptoms, requiring more robust studies to define effective scar management protocols.http://www.rbcp.org.br/export-pdf/3416/1983-5175-rbcp-39-01-e0841-en.pdfkeloidtherapeutic human experimentationbotulinum toxinstype areconstructive surgical proceduresevidence-based practice |
| spellingShingle | Eduardo Lafayette Monteiro Karine Lorena Sousa Queiroz Thiago Alexandre Macedo de Azevedo Use of botulinum toxin for the treatment of keloid scars: scoping review Revista Brasileira de Cirurgia Plástica keloid therapeutic human experimentation botulinum toxins type a reconstructive surgical procedures evidence-based practice |
| title | Use of botulinum toxin for the treatment of keloid scars: scoping review |
| title_full | Use of botulinum toxin for the treatment of keloid scars: scoping review |
| title_fullStr | Use of botulinum toxin for the treatment of keloid scars: scoping review |
| title_full_unstemmed | Use of botulinum toxin for the treatment of keloid scars: scoping review |
| title_short | Use of botulinum toxin for the treatment of keloid scars: scoping review |
| title_sort | use of botulinum toxin for the treatment of keloid scars scoping review |
| topic | keloid therapeutic human experimentation botulinum toxins type a reconstructive surgical procedures evidence-based practice |
| url | http://www.rbcp.org.br/export-pdf/3416/1983-5175-rbcp-39-01-e0841-en.pdf |
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