Genotoxicity induced by endodontic sealers: A systematic review
Introduction: This systematic review aimed to help further elucidate the following question: are endodontics sealers able to induce DNA damage in vitro or in vivo? Methods: This study was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement 20...
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| Format: | Article |
| Language: | English |
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Springer
2024-02-01
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| Series: | Saudi Dental Journal |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1013905223002420 |
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| author | Thiago Guedes Pinto Ana Claudia Muniz Renno Jean Nunes dos Santos Patricia Ramos Cury Daniel Araki Ribeiro |
| author_facet | Thiago Guedes Pinto Ana Claudia Muniz Renno Jean Nunes dos Santos Patricia Ramos Cury Daniel Araki Ribeiro |
| author_sort | Thiago Guedes Pinto |
| collection | DOAJ |
| description | Introduction: This systematic review aimed to help further elucidate the following question: are endodontics sealers able to induce DNA damage in vitro or in vivo? Methods: This study was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement 2020 criteria. A total of 23 studies were carefully selected by the authors. Results: Regarding the general characteristics, most studies evaluated, on average, 3–5 types of sealers (resin epoxy, salicylate, salicylate + MTA, zinc oxide-eugenol, bioceramic products, calcium hydroxide), performing comparisons between them. Our results demonstrate that endodontic sealers may be a genotoxic agent since most studies demonstrated positive findings, with the resin-based ones being the most potentially genotoxic. Conclusion: The type of genotoxicity assay, material evaluated, and dilution concentration levels influenced the outcome. This study clarifies whether and to what extent endodontic sealers are capable of inducing DNA injury in oral tissues. |
| format | Article |
| id | doaj-art-7a1e82765d2b4aa887f576a140fc2dbd |
| institution | DOAJ |
| issn | 1013-9052 |
| language | English |
| publishDate | 2024-02-01 |
| publisher | Springer |
| record_format | Article |
| series | Saudi Dental Journal |
| spelling | doaj-art-7a1e82765d2b4aa887f576a140fc2dbd2025-08-20T03:07:04ZengSpringerSaudi Dental Journal1013-90522024-02-0136224925710.1016/j.sdentj.2023.11.019Genotoxicity induced by endodontic sealers: A systematic reviewThiago Guedes Pinto0Ana Claudia Muniz Renno1Jean Nunes dos Santos2Patricia Ramos Cury3Daniel Araki Ribeiro4Department of Biosciences, Institute of Health and Society, Federal University of São Paulo, UNIFESP, Santos, SP, BrazilDepartment of Biosciences, Institute of Health and Society, Federal University of São Paulo, UNIFESP, Santos, SP, BrazilDepartment of Dental Clinics, Federal University of Bahia, UFBA, Salvador, BA, BrazilDepartment of Dental Clinics, Federal University of Bahia, UFBA, Salvador, BA, BrazilDepartment of Biosciences, Institute of Health and Society, Federal University of São Paulo, UNIFESP, Santos, SP, Brazil; Corresponding author at: Department of Biosciences, Federal University of Sao Paulo, UNIFESP, Rua Silva Jardim, 136, Room 332, Vila Mathias, Santos, SP 11050-020, Brazil.Introduction: This systematic review aimed to help further elucidate the following question: are endodontics sealers able to induce DNA damage in vitro or in vivo? Methods: This study was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement 2020 criteria. A total of 23 studies were carefully selected by the authors. Results: Regarding the general characteristics, most studies evaluated, on average, 3–5 types of sealers (resin epoxy, salicylate, salicylate + MTA, zinc oxide-eugenol, bioceramic products, calcium hydroxide), performing comparisons between them. Our results demonstrate that endodontic sealers may be a genotoxic agent since most studies demonstrated positive findings, with the resin-based ones being the most potentially genotoxic. Conclusion: The type of genotoxicity assay, material evaluated, and dilution concentration levels influenced the outcome. This study clarifies whether and to what extent endodontic sealers are capable of inducing DNA injury in oral tissues.http://www.sciencedirect.com/science/article/pii/S1013905223002420GenotoxicityEndodontic sealersDNA damage |
| spellingShingle | Thiago Guedes Pinto Ana Claudia Muniz Renno Jean Nunes dos Santos Patricia Ramos Cury Daniel Araki Ribeiro Genotoxicity induced by endodontic sealers: A systematic review Saudi Dental Journal Genotoxicity Endodontic sealers DNA damage |
| title | Genotoxicity induced by endodontic sealers: A systematic review |
| title_full | Genotoxicity induced by endodontic sealers: A systematic review |
| title_fullStr | Genotoxicity induced by endodontic sealers: A systematic review |
| title_full_unstemmed | Genotoxicity induced by endodontic sealers: A systematic review |
| title_short | Genotoxicity induced by endodontic sealers: A systematic review |
| title_sort | genotoxicity induced by endodontic sealers a systematic review |
| topic | Genotoxicity Endodontic sealers DNA damage |
| url | http://www.sciencedirect.com/science/article/pii/S1013905223002420 |
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