Cross-species comparison of rodent and human decision-making in the Iowa Gambling Task in select neurological and psychiatric disorders: translational approach to examine age- and sex-specific effects of stress and corticolimbic perturbations

Cross-species comparison of rodent and human decision-making in the Iowa Gambling Task in select neurological and psychiatric disorders: translational approach to examine age- and sex-specific effects of stress and corticolimbic perturbations

IntroductionRodent models are widely used to understand brain pathologies and address cognitive deficits experienced by humans diagnosed with clinical disorders. However, stark differences in the nervous system and in the environmental demands of rodents and humans make it difficult to translate ins...

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Main Authors: Varsha Singh, Manjari Tripathi, Sarat P. Chandra, Rohit Verma, Sushil Kumar Jha, Harvinder Singh Chhabra, Mrinmoy Chakravarty, Shambhovi Mitra, Indupriya B, Ankit Jha, Sakshi Sharma, Jyotsna Pandey, Divyanshi Pandey, Insha Shamshad, Ekta Ahlawat, Titli Saha, Chloé César, Suman Jain
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Psychiatry
Subjects:
Iowa Gambling Task (IGT)
decision making
animal cognition
rodent models
risk–reward
stress
Online Access:https://www.frontiersin.org/articles/10.3389/fpsyt.2025.1551477/full
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