Comprehensive evaluation of the MeltPro MTB/PZA assay for prediction of pyrazinamide resistance in multidrug-resistant tuberculosis

Comprehensive evaluation of the MeltPro MTB/PZA assay for prediction of pyrazinamide resistance in multidrug-resistant tuberculosis

ABSTRACT Resistance to pyrazinamide (PZA) poses significant challenges to tuberculosis (TB) management, and prediction of susceptibility to PZA has been challenging. This study examined PZA resistance-associated gene mutations in 125 multidrug-resistant clinical isolates of Mycobacterium tuberculosi...

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Bibliographic Details
Main Authors:	Guiqing He, Chunxia Tu, Yelei Zhu, Qingyong Zheng, Qiulong Zhou, Wenzhen Zhou, Ouyang Huang, Bin Chen, Zhengwei Liu, Ye Xu, Xiangao Jiang
Format:	Article
Language:	English
Published:	American Society for Microbiology 2025-07-01
Series:	Microbiology Spectrum
Subjects:	multidrug-resistant TB pyrazinamide pncA MeltPro MTB/PZA assay pDST
Online Access:	https://journals.asm.org/doi/10.1128/spectrum.02745-24
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