Test-retest repeatability of quantitative organ and tissue uptake using 20-minute dynamic multiparametric whole-body [18F]FDG PET/CT in patients with type 2 diabetes
Abstract Background Recently developed dynamic whole-body PET/CT (D-WB PET/CT) protocols allow for measurements of potentially more precise metabolic parameters than the commonly used semiquantitative SUV. Most notable is the metabolic rate of FDG uptake (MRFDG), which reflects quantitative glucose...
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SpringerOpen
2025-05-01
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| Series: | EJNMMI Research |
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| Online Access: | https://doi.org/10.1186/s13550-025-01249-z |
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| author | Jonathan M. Baier Kristian L. Funck Anna Dons-Jensen Ole L. Munk Lars P. Tolbod Esben Laugesen Per L. Poulsen Lars C. Gormsen André H. Dias |
| author_facet | Jonathan M. Baier Kristian L. Funck Anna Dons-Jensen Ole L. Munk Lars P. Tolbod Esben Laugesen Per L. Poulsen Lars C. Gormsen André H. Dias |
| author_sort | Jonathan M. Baier |
| collection | DOAJ |
| description | Abstract Background Recently developed dynamic whole-body PET/CT (D-WB PET/CT) protocols allow for measurements of potentially more precise metabolic parameters than the commonly used semiquantitative SUV. Most notable is the metabolic rate of FDG uptake (MRFDG), which reflects quantitative glucose uptake into tissues and organs. However, data on the reproducibility of MRFDG measurements are scarce, particularly in patients with perturbed glucose homeostasis such as type 2 diabetes. We therefore aimed to evaluate the test-retest repeatability of both MRFDG and SUV in these patients. Results Fifteen participants (mean age 71 ± 7 years; 2 females) with type 2 diabetes underwent a short 20-minute [18F]FDG D-WB PET/CT after 6 h fasting on two consecutive days. Both SUV and MRFDG images were reconstructed from D-WB PET/CT data obtained 60–80 min post-injection of [18F]FDG. MRFDG and SUV data were measured in organs and tissues, and repeatability was assessed with Bland-Altman analysis, intraclass correlation coefficients (ICC), repeatability coefficients (RPC) and coefficients of variation (wCV). There was high repeatability of both SUVmean and MRFDG−mean in all measured organs (ICC range: 0.65–0.95 for SUVmean and 0.66–0.94 for MRFDG−mean). SUVmean generally demonstrated higher reliability (ICC) and lower variability (%RPC and %wCV) when compared to MRFDG−mean. However, MRFDG test-retest variation was < 19% in most analysed tissues, demonstrating that MRFDG may be used as a precise marker of treatment response. Conclusion This study demonstrates that MRFDG calculated from D-WB PET/CT exhibit high repeatability, comparable to SUVs across most organs in patients with type 2 diabetes. |
| format | Article |
| id | doaj-art-7a106ad4dafb4cc98208bdc86f6969a8 |
| institution | OA Journals |
| issn | 2191-219X |
| language | English |
| publishDate | 2025-05-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | EJNMMI Research |
| spelling | doaj-art-7a106ad4dafb4cc98208bdc86f6969a82025-08-20T01:51:36ZengSpringerOpenEJNMMI Research2191-219X2025-05-0115111110.1186/s13550-025-01249-zTest-retest repeatability of quantitative organ and tissue uptake using 20-minute dynamic multiparametric whole-body [18F]FDG PET/CT in patients with type 2 diabetesJonathan M. Baier0Kristian L. Funck1Anna Dons-Jensen2Ole L. Munk3Lars P. Tolbod4Esben Laugesen5Per L. Poulsen6Lars C. Gormsen7André H. Dias8Dept. of Clinical Medicine, Aarhus UniversitySteno Diabetes Center Aarhus, Aarhus University HospitalSteno Diabetes Center Aarhus, Aarhus University HospitalDept. of Clinical Medicine, Aarhus UniversityDept. of Clinical Medicine, Aarhus UniversitySteno Diabetes Center Aarhus, Aarhus University HospitalDept. of Clinical Medicine, Aarhus UniversityDept. of Clinical Medicine, Aarhus UniversityDepartment of Nuclear Medicine & PET-Centre, Aarhus University HospitalAbstract Background Recently developed dynamic whole-body PET/CT (D-WB PET/CT) protocols allow for measurements of potentially more precise metabolic parameters than the commonly used semiquantitative SUV. Most notable is the metabolic rate of FDG uptake (MRFDG), which reflects quantitative glucose uptake into tissues and organs. However, data on the reproducibility of MRFDG measurements are scarce, particularly in patients with perturbed glucose homeostasis such as type 2 diabetes. We therefore aimed to evaluate the test-retest repeatability of both MRFDG and SUV in these patients. Results Fifteen participants (mean age 71 ± 7 years; 2 females) with type 2 diabetes underwent a short 20-minute [18F]FDG D-WB PET/CT after 6 h fasting on two consecutive days. Both SUV and MRFDG images were reconstructed from D-WB PET/CT data obtained 60–80 min post-injection of [18F]FDG. MRFDG and SUV data were measured in organs and tissues, and repeatability was assessed with Bland-Altman analysis, intraclass correlation coefficients (ICC), repeatability coefficients (RPC) and coefficients of variation (wCV). There was high repeatability of both SUVmean and MRFDG−mean in all measured organs (ICC range: 0.65–0.95 for SUVmean and 0.66–0.94 for MRFDG−mean). SUVmean generally demonstrated higher reliability (ICC) and lower variability (%RPC and %wCV) when compared to MRFDG−mean. However, MRFDG test-retest variation was < 19% in most analysed tissues, demonstrating that MRFDG may be used as a precise marker of treatment response. Conclusion This study demonstrates that MRFDG calculated from D-WB PET/CT exhibit high repeatability, comparable to SUVs across most organs in patients with type 2 diabetes.https://doi.org/10.1186/s13550-025-01249-zTest-retestPET/CTDynamic whole-body PETParametric imagingFDGDiabetes |
| spellingShingle | Jonathan M. Baier Kristian L. Funck Anna Dons-Jensen Ole L. Munk Lars P. Tolbod Esben Laugesen Per L. Poulsen Lars C. Gormsen André H. Dias Test-retest repeatability of quantitative organ and tissue uptake using 20-minute dynamic multiparametric whole-body [18F]FDG PET/CT in patients with type 2 diabetes EJNMMI Research Test-retest PET/CT Dynamic whole-body PET Parametric imaging FDG Diabetes |
| title | Test-retest repeatability of quantitative organ and tissue uptake using 20-minute dynamic multiparametric whole-body [18F]FDG PET/CT in patients with type 2 diabetes |
| title_full | Test-retest repeatability of quantitative organ and tissue uptake using 20-minute dynamic multiparametric whole-body [18F]FDG PET/CT in patients with type 2 diabetes |
| title_fullStr | Test-retest repeatability of quantitative organ and tissue uptake using 20-minute dynamic multiparametric whole-body [18F]FDG PET/CT in patients with type 2 diabetes |
| title_full_unstemmed | Test-retest repeatability of quantitative organ and tissue uptake using 20-minute dynamic multiparametric whole-body [18F]FDG PET/CT in patients with type 2 diabetes |
| title_short | Test-retest repeatability of quantitative organ and tissue uptake using 20-minute dynamic multiparametric whole-body [18F]FDG PET/CT in patients with type 2 diabetes |
| title_sort | test retest repeatability of quantitative organ and tissue uptake using 20 minute dynamic multiparametric whole body 18f fdg pet ct in patients with type 2 diabetes |
| topic | Test-retest PET/CT Dynamic whole-body PET Parametric imaging FDG Diabetes |
| url | https://doi.org/10.1186/s13550-025-01249-z |
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