Bacterial Infections, DNA Virus Infections, and RNA Virus Infections Manifest Differently in Neutrophil Receptor Expression
Treating viral illnesses or noninfective causes of inflammation with antibiotics is ineffective and contributes to the development of antibiotic resistance, toxicity, and allergic reactions, leading to increasing medical costs. A major factor behind unnecessary use of antibiotics is, of course, inco...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/2012/527347 |
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| author | Esa-Matti Lilius Jari Nuutila |
| author_facet | Esa-Matti Lilius Jari Nuutila |
| author_sort | Esa-Matti Lilius |
| collection | DOAJ |
| description | Treating viral illnesses or noninfective causes of inflammation with antibiotics is ineffective and contributes to the development of antibiotic resistance, toxicity, and allergic reactions, leading to increasing medical costs. A major factor behind unnecessary use of antibiotics is, of course, incorrect diagnosis. For this reason, timely and accurate information on whether the infection is bacterial in origin would be highly beneficial. In this paper we will present our recent studies on the expression of opsonin receptors on phagocytes. The analysis of the expression levels of FcγRI, CR1, and CR3, along with CRP and ESR data, provides a novel application to the diagnosis of infectious and inflammatory diseases. The best clinical benefit will be obtained when the individual variables are combined to generate the CIS point method for a bacterial infection marker, DNAVS point for differentiating between DNA and RNA virus infections, and CRP/CD11b ratio for a marker of Gram-positive sepsis. |
| format | Article |
| id | doaj-art-7a045949c4e246538e08ea6a6102051c |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-7a045949c4e246538e08ea6a6102051c2025-02-03T05:43:36ZengWileyThe Scientific World Journal1537-744X2012-01-01201210.1100/2012/527347527347Bacterial Infections, DNA Virus Infections, and RNA Virus Infections Manifest Differently in Neutrophil Receptor ExpressionEsa-Matti Lilius0Jari Nuutila1Department of Biochemistry, University of Turku, 20014 Turku, FinlandDepartment of Biochemistry, University of Turku, 20014 Turku, FinlandTreating viral illnesses or noninfective causes of inflammation with antibiotics is ineffective and contributes to the development of antibiotic resistance, toxicity, and allergic reactions, leading to increasing medical costs. A major factor behind unnecessary use of antibiotics is, of course, incorrect diagnosis. For this reason, timely and accurate information on whether the infection is bacterial in origin would be highly beneficial. In this paper we will present our recent studies on the expression of opsonin receptors on phagocytes. The analysis of the expression levels of FcγRI, CR1, and CR3, along with CRP and ESR data, provides a novel application to the diagnosis of infectious and inflammatory diseases. The best clinical benefit will be obtained when the individual variables are combined to generate the CIS point method for a bacterial infection marker, DNAVS point for differentiating between DNA and RNA virus infections, and CRP/CD11b ratio for a marker of Gram-positive sepsis.http://dx.doi.org/10.1100/2012/527347 |
| spellingShingle | Esa-Matti Lilius Jari Nuutila Bacterial Infections, DNA Virus Infections, and RNA Virus Infections Manifest Differently in Neutrophil Receptor Expression The Scientific World Journal |
| title | Bacterial Infections, DNA Virus Infections, and RNA Virus Infections Manifest Differently in Neutrophil Receptor Expression |
| title_full | Bacterial Infections, DNA Virus Infections, and RNA Virus Infections Manifest Differently in Neutrophil Receptor Expression |
| title_fullStr | Bacterial Infections, DNA Virus Infections, and RNA Virus Infections Manifest Differently in Neutrophil Receptor Expression |
| title_full_unstemmed | Bacterial Infections, DNA Virus Infections, and RNA Virus Infections Manifest Differently in Neutrophil Receptor Expression |
| title_short | Bacterial Infections, DNA Virus Infections, and RNA Virus Infections Manifest Differently in Neutrophil Receptor Expression |
| title_sort | bacterial infections dna virus infections and rna virus infections manifest differently in neutrophil receptor expression |
| url | http://dx.doi.org/10.1100/2012/527347 |
| work_keys_str_mv | AT esamattililius bacterialinfectionsdnavirusinfectionsandrnavirusinfectionsmanifestdifferentlyinneutrophilreceptorexpression AT jarinuutila bacterialinfectionsdnavirusinfectionsandrnavirusinfectionsmanifestdifferentlyinneutrophilreceptorexpression |