Aggregation induced emission luminogen bacteria hybrid bionic robot for multimodal phototheranostics and immunotherapy
Abstract Multimodal phototheranostics utilizing single molecules offer a “one-and-done” approach, presenting a convenient and effective strategy for cancer therapy. However, therapies based on conventional photosensitizers often suffer from limitations such as a single photosensitizing mechanism, re...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-025-57533-y |
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| author | Liwei Zhu Guangjie Song Wentian Zhang Yifan Wu Yuling Chen Jiayi Song Deliang Wang Guoxin Li Ben Zhong Tang Ying Li |
| author_facet | Liwei Zhu Guangjie Song Wentian Zhang Yifan Wu Yuling Chen Jiayi Song Deliang Wang Guoxin Li Ben Zhong Tang Ying Li |
| author_sort | Liwei Zhu |
| collection | DOAJ |
| description | Abstract Multimodal phototheranostics utilizing single molecules offer a “one-and-done” approach, presenting a convenient and effective strategy for cancer therapy. However, therapies based on conventional photosensitizers often suffer from limitations such as a single photosensitizing mechanism, restricted tumor penetration and retention, and the requirement for multiple irradiations, which significantly constrain their application. In this report, we present an aggregation-induced emission luminogen (AIEgen) bacteria hybrid bionic robot to address above issues. This bionic robot is composed of multifunctional AIEgen (INX-2) and Escherichia coli Nissle 1917 (EcN), i.e., EcN@INX-2. The EcN@INX-2 bionic robot exhibits near-infrared II (NIR-II) fluorescence emission and demonstrates efficient photodynamic and photothermal effects, as well as tumor-targeting capabilities. These features are facilitated by the complementary roles of INX-2 and EcN. The robot successfully enables in vivo multimodal imaging and therapy of colon cancer models in female mice through various mechanisms, including the activation of anti-tumor immunity, as well as photodynamic and photothermal therapy. Our study paves an avenue for designing multifunctional diagnostic agents for targeted colon cancer therapy through image-guided combinational immunotherapy. |
| format | Article |
| id | doaj-art-7a027a54492b4e68a3b430a22ef08c0b |
| institution | DOAJ |
| issn | 2041-1723 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-7a027a54492b4e68a3b430a22ef08c0b2025-08-20T03:02:21ZengNature PortfolioNature Communications2041-17232025-03-0116111810.1038/s41467-025-57533-yAggregation induced emission luminogen bacteria hybrid bionic robot for multimodal phototheranostics and immunotherapyLiwei Zhu0Guangjie Song1Wentian Zhang2Yifan Wu3Yuling Chen4Jiayi Song5Deliang Wang6Guoxin Li7Ben Zhong Tang8Ying Li9Innovation Research Center for AIE Pharmaceutical Biology, Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, the NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences and the Second Affiliated Hospital, Guangzhou Medical UniversityCenter for AIE Research, Shenzhen Key Laboratory of Polymer Science and Technology, Guangdong Research Center for Interfacial Engineering of Functional Materials, College of Materials Science and Engineering, Shenzhen UniversityInnovation Research Center for AIE Pharmaceutical Biology, Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, the NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences and the Second Affiliated Hospital, Guangzhou Medical UniversityInnovation Research Center for AIE Pharmaceutical Biology, Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, the NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences and the Second Affiliated Hospital, Guangzhou Medical UniversityInnovation Research Center for AIE Pharmaceutical Biology, Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, the NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences and the Second Affiliated Hospital, Guangzhou Medical UniversityInnovation Research Center for AIE Pharmaceutical Biology, Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, the NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences and the Second Affiliated Hospital, Guangzhou Medical UniversityDepartment of Materials Chemistry, Huzhou UniversityCancer Center of Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua Medicine, Tsinghua UniversitySchool of Science and Engineering, Shenzhen Institute of Aggregate Science and Technology, The Chinese University of Hong KongInnovation Research Center for AIE Pharmaceutical Biology, Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, the NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences and the Second Affiliated Hospital, Guangzhou Medical UniversityAbstract Multimodal phototheranostics utilizing single molecules offer a “one-and-done” approach, presenting a convenient and effective strategy for cancer therapy. However, therapies based on conventional photosensitizers often suffer from limitations such as a single photosensitizing mechanism, restricted tumor penetration and retention, and the requirement for multiple irradiations, which significantly constrain their application. In this report, we present an aggregation-induced emission luminogen (AIEgen) bacteria hybrid bionic robot to address above issues. This bionic robot is composed of multifunctional AIEgen (INX-2) and Escherichia coli Nissle 1917 (EcN), i.e., EcN@INX-2. The EcN@INX-2 bionic robot exhibits near-infrared II (NIR-II) fluorescence emission and demonstrates efficient photodynamic and photothermal effects, as well as tumor-targeting capabilities. These features are facilitated by the complementary roles of INX-2 and EcN. The robot successfully enables in vivo multimodal imaging and therapy of colon cancer models in female mice through various mechanisms, including the activation of anti-tumor immunity, as well as photodynamic and photothermal therapy. Our study paves an avenue for designing multifunctional diagnostic agents for targeted colon cancer therapy through image-guided combinational immunotherapy.https://doi.org/10.1038/s41467-025-57533-y |
| spellingShingle | Liwei Zhu Guangjie Song Wentian Zhang Yifan Wu Yuling Chen Jiayi Song Deliang Wang Guoxin Li Ben Zhong Tang Ying Li Aggregation induced emission luminogen bacteria hybrid bionic robot for multimodal phototheranostics and immunotherapy Nature Communications |
| title | Aggregation induced emission luminogen bacteria hybrid bionic robot for multimodal phototheranostics and immunotherapy |
| title_full | Aggregation induced emission luminogen bacteria hybrid bionic robot for multimodal phototheranostics and immunotherapy |
| title_fullStr | Aggregation induced emission luminogen bacteria hybrid bionic robot for multimodal phototheranostics and immunotherapy |
| title_full_unstemmed | Aggregation induced emission luminogen bacteria hybrid bionic robot for multimodal phototheranostics and immunotherapy |
| title_short | Aggregation induced emission luminogen bacteria hybrid bionic robot for multimodal phototheranostics and immunotherapy |
| title_sort | aggregation induced emission luminogen bacteria hybrid bionic robot for multimodal phototheranostics and immunotherapy |
| url | https://doi.org/10.1038/s41467-025-57533-y |
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