Evaluating the role of inflammatory biomarkers as a diagnostic tool in peri-implantitis
Background: Most studies have analyzed the presence of cytokines in Gingival crevicular fluid (GCF) in different periodontal diseases, but very limited studies have been conducted on Peri-implant crevicular fluid (PICF) in peri-implantitis. Aim: The present study was conceptualized to explore the le...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-03-01
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| Series: | Journal of Oral Biology and Craniofacial Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S221242682500017X |
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| author | Ayan Saxena Pavitra Kumar Rastogi Nand Lal Umesh Pratap Verma Rameshwari Singhal Md. Kaleem Ahmad |
| author_facet | Ayan Saxena Pavitra Kumar Rastogi Nand Lal Umesh Pratap Verma Rameshwari Singhal Md. Kaleem Ahmad |
| author_sort | Ayan Saxena |
| collection | DOAJ |
| description | Background: Most studies have analyzed the presence of cytokines in Gingival crevicular fluid (GCF) in different periodontal diseases, but very limited studies have been conducted on Peri-implant crevicular fluid (PICF) in peri-implantitis. Aim: The present study was conceptualized to explore the levels of Interleukin (IL)-1β and Interleukin (IL)-6 as a diagnostic marker in peri-implantitis. Materials and methods: A total of 40 patients each having at least one dental implant were enrolled in the study. Clinical parameters were recorded around each implant and tooth nearest to it. Gingival crevicular fluid (GCF)/Peri-implant crevicular fluid (PICF) was collected to evaluate the concentration of IL‐1β and IL‐6. Conservative treatment was performed in peri-implantitis cases, 3 months after treatment their clinical parameters, IL-1β and IL-6 levels were recorded and compared with their pre-treatment values. Results: Clinical parameters like Modified Plaque Index (MPI), Modified Bleeding Index (MBI) and Probing Pocket Depth (PPD) were statistically significantly higher in the peri-implantitis group as compared to the healthy implant group and healthy teeth group. IL-1β and IL-6 levels were also statistically significantly higher in the peri-implantitis group in comparison to healthy implants and healthy teeth group. Conclusion: The study concludes that biomarkers in PICF can be used as a diagnostic tool to supplement the diagnosis of peri-implantitis along with the use of clinical parameters to make an early diagnosis of peri-implantitis possible. |
| format | Article |
| id | doaj-art-7a00a0a819c244f5aaeb9746e75b5e93 |
| institution | Kabale University |
| issn | 2212-4268 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Oral Biology and Craniofacial Research |
| spelling | doaj-art-7a00a0a819c244f5aaeb9746e75b5e932025-02-10T04:34:20ZengElsevierJournal of Oral Biology and Craniofacial Research2212-42682025-03-01152228233Evaluating the role of inflammatory biomarkers as a diagnostic tool in peri-implantitisAyan Saxena0Pavitra Kumar Rastogi1Nand Lal2Umesh Pratap Verma3Rameshwari Singhal4Md. Kaleem Ahmad5Department of Periodontology, King George's Medical University, IndiaDepartment of Periodontology, King George's Medical University, India; Corresponding author.Department of Periodontology, King George's Medical University, IndiaDepartment of Periodontology, King George's Medical University, IndiaDepartment of Periodontology, King George's Medical University, IndiaDepartment of Biochemistry, King George's Medical University, IndiaBackground: Most studies have analyzed the presence of cytokines in Gingival crevicular fluid (GCF) in different periodontal diseases, but very limited studies have been conducted on Peri-implant crevicular fluid (PICF) in peri-implantitis. Aim: The present study was conceptualized to explore the levels of Interleukin (IL)-1β and Interleukin (IL)-6 as a diagnostic marker in peri-implantitis. Materials and methods: A total of 40 patients each having at least one dental implant were enrolled in the study. Clinical parameters were recorded around each implant and tooth nearest to it. Gingival crevicular fluid (GCF)/Peri-implant crevicular fluid (PICF) was collected to evaluate the concentration of IL‐1β and IL‐6. Conservative treatment was performed in peri-implantitis cases, 3 months after treatment their clinical parameters, IL-1β and IL-6 levels were recorded and compared with their pre-treatment values. Results: Clinical parameters like Modified Plaque Index (MPI), Modified Bleeding Index (MBI) and Probing Pocket Depth (PPD) were statistically significantly higher in the peri-implantitis group as compared to the healthy implant group and healthy teeth group. IL-1β and IL-6 levels were also statistically significantly higher in the peri-implantitis group in comparison to healthy implants and healthy teeth group. Conclusion: The study concludes that biomarkers in PICF can be used as a diagnostic tool to supplement the diagnosis of peri-implantitis along with the use of clinical parameters to make an early diagnosis of peri-implantitis possible.http://www.sciencedirect.com/science/article/pii/S221242682500017XPeri-implantitisHealthy implantInterleukin-1βInterleukin-6 |
| spellingShingle | Ayan Saxena Pavitra Kumar Rastogi Nand Lal Umesh Pratap Verma Rameshwari Singhal Md. Kaleem Ahmad Evaluating the role of inflammatory biomarkers as a diagnostic tool in peri-implantitis Journal of Oral Biology and Craniofacial Research Peri-implantitis Healthy implant Interleukin-1β Interleukin-6 |
| title | Evaluating the role of inflammatory biomarkers as a diagnostic tool in peri-implantitis |
| title_full | Evaluating the role of inflammatory biomarkers as a diagnostic tool in peri-implantitis |
| title_fullStr | Evaluating the role of inflammatory biomarkers as a diagnostic tool in peri-implantitis |
| title_full_unstemmed | Evaluating the role of inflammatory biomarkers as a diagnostic tool in peri-implantitis |
| title_short | Evaluating the role of inflammatory biomarkers as a diagnostic tool in peri-implantitis |
| title_sort | evaluating the role of inflammatory biomarkers as a diagnostic tool in peri implantitis |
| topic | Peri-implantitis Healthy implant Interleukin-1β Interleukin-6 |
| url | http://www.sciencedirect.com/science/article/pii/S221242682500017X |
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