Serum alpha-klotho levels associate with bone mineral density in chronic kidney disease patients from NHANES 2011 to 2016
Abstract This study investigated the relationship between serum Alpha-Klotho (α-Klotho) levels and bone mineral density (BMD) in patients with chronic kidney disease (CKD) using data from the National Health and Nutrition Examination Survey (NHANES) 2011–2016. A population of 781 CKD patients aged ≥...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-05-01
|
| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-025-04024-1 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849688310576840704 |
|---|---|
| author | Yani Zhang Rui Qi Xinwei Luo Jin Lu Xueying Zhao Liyuan Wang |
| author_facet | Yani Zhang Rui Qi Xinwei Luo Jin Lu Xueying Zhao Liyuan Wang |
| author_sort | Yani Zhang |
| collection | DOAJ |
| description | Abstract This study investigated the relationship between serum Alpha-Klotho (α-Klotho) levels and bone mineral density (BMD) in patients with chronic kidney disease (CKD) using data from the National Health and Nutrition Examination Survey (NHANES) 2011–2016. A population of 781 CKD patients aged ≥ 40 years was analyzed using multiple linear regression models to examine the association between serum α-Klotho levels and BMD at different skeletal sites, with adjustments for demographic, lifestyle, and clinical factors. Results showed that serum α-Klotho levels were significantly correlated with BMD at thoracic spine (β = 0.004 g/cm2, p = 0.00264), total BMD (β = 0.003 g/cm2, p = 0.02591), and trunk BMD (β = 0.002 g/cm2, p = 0.03708), while no significant associations were observed at the left leg, lumbar spine, or pelvis. Stratified analyses showed that the association was more pronounced in men, non-Hispanic whites, those with a body mass index greater than 29.9 kg/m2, and those without hypertension and diabetes. The inconsistent associations observed across different skeletal sites suggest that it remains unclear whether serum α-Klotho levels are consistently associated with BMD in CKD patients. Additionally, the cross-sectional design precludes any determination of causality in the observed site-specific associations. |
| format | Article |
| id | doaj-art-79fbecf1baea48d5b9f36ad802bddfac |
| institution | DOAJ |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-79fbecf1baea48d5b9f36ad802bddfac2025-08-20T03:22:03ZengNature PortfolioScientific Reports2045-23222025-05-0115111310.1038/s41598-025-04024-1Serum alpha-klotho levels associate with bone mineral density in chronic kidney disease patients from NHANES 2011 to 2016Yani Zhang0Rui Qi1Xinwei Luo2Jin Lu3Xueying Zhao4Liyuan Wang5School of Basic Medical Sciences, Bengbu Medical UniversitySchool of Basic Medical Sciences, Bengbu Medical UniversitySchool of Basic Medical Sciences, Bengbu Medical UniversitySchool of Basic Medical Sciences, Bengbu Medical UniversitySchool of Basic Medical Sciences, Bengbu Medical UniversitySchool of Basic Medical Sciences, Bengbu Medical UniversityAbstract This study investigated the relationship between serum Alpha-Klotho (α-Klotho) levels and bone mineral density (BMD) in patients with chronic kidney disease (CKD) using data from the National Health and Nutrition Examination Survey (NHANES) 2011–2016. A population of 781 CKD patients aged ≥ 40 years was analyzed using multiple linear regression models to examine the association between serum α-Klotho levels and BMD at different skeletal sites, with adjustments for demographic, lifestyle, and clinical factors. Results showed that serum α-Klotho levels were significantly correlated with BMD at thoracic spine (β = 0.004 g/cm2, p = 0.00264), total BMD (β = 0.003 g/cm2, p = 0.02591), and trunk BMD (β = 0.002 g/cm2, p = 0.03708), while no significant associations were observed at the left leg, lumbar spine, or pelvis. Stratified analyses showed that the association was more pronounced in men, non-Hispanic whites, those with a body mass index greater than 29.9 kg/m2, and those without hypertension and diabetes. The inconsistent associations observed across different skeletal sites suggest that it remains unclear whether serum α-Klotho levels are consistently associated with BMD in CKD patients. Additionally, the cross-sectional design precludes any determination of causality in the observed site-specific associations.https://doi.org/10.1038/s41598-025-04024-1Alpha-KlothoBone mineral densityChronic kidney diseaseNHANES |
| spellingShingle | Yani Zhang Rui Qi Xinwei Luo Jin Lu Xueying Zhao Liyuan Wang Serum alpha-klotho levels associate with bone mineral density in chronic kidney disease patients from NHANES 2011 to 2016 Scientific Reports Alpha-Klotho Bone mineral density Chronic kidney disease NHANES |
| title | Serum alpha-klotho levels associate with bone mineral density in chronic kidney disease patients from NHANES 2011 to 2016 |
| title_full | Serum alpha-klotho levels associate with bone mineral density in chronic kidney disease patients from NHANES 2011 to 2016 |
| title_fullStr | Serum alpha-klotho levels associate with bone mineral density in chronic kidney disease patients from NHANES 2011 to 2016 |
| title_full_unstemmed | Serum alpha-klotho levels associate with bone mineral density in chronic kidney disease patients from NHANES 2011 to 2016 |
| title_short | Serum alpha-klotho levels associate with bone mineral density in chronic kidney disease patients from NHANES 2011 to 2016 |
| title_sort | serum alpha klotho levels associate with bone mineral density in chronic kidney disease patients from nhanes 2011 to 2016 |
| topic | Alpha-Klotho Bone mineral density Chronic kidney disease NHANES |
| url | https://doi.org/10.1038/s41598-025-04024-1 |
| work_keys_str_mv | AT yanizhang serumalphaklotholevelsassociatewithbonemineraldensityinchronickidneydiseasepatientsfromnhanes2011to2016 AT ruiqi serumalphaklotholevelsassociatewithbonemineraldensityinchronickidneydiseasepatientsfromnhanes2011to2016 AT xinweiluo serumalphaklotholevelsassociatewithbonemineraldensityinchronickidneydiseasepatientsfromnhanes2011to2016 AT jinlu serumalphaklotholevelsassociatewithbonemineraldensityinchronickidneydiseasepatientsfromnhanes2011to2016 AT xueyingzhao serumalphaklotholevelsassociatewithbonemineraldensityinchronickidneydiseasepatientsfromnhanes2011to2016 AT liyuanwang serumalphaklotholevelsassociatewithbonemineraldensityinchronickidneydiseasepatientsfromnhanes2011to2016 |