Emerging Synaptic Molecules as Candidates in the Etiology of Neurological Disorders
Synapses are complex structures that allow communication between neurons in the central nervous system. Studies conducted in vertebrate and invertebrate models have contributed to the knowledge of the function of synaptic proteins. The functional synapse requires numerous protein complexes with spec...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2017/8081758 |
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| author | Viviana I. Torres Daniela Vallejo Nibaldo C. Inestrosa |
| author_facet | Viviana I. Torres Daniela Vallejo Nibaldo C. Inestrosa |
| author_sort | Viviana I. Torres |
| collection | DOAJ |
| description | Synapses are complex structures that allow communication between neurons in the central nervous system. Studies conducted in vertebrate and invertebrate models have contributed to the knowledge of the function of synaptic proteins. The functional synapse requires numerous protein complexes with specialized functions that are regulated in space and time to allow synaptic plasticity. However, their interplay during neuronal development, learning, and memory is poorly understood. Accumulating evidence links synapse proteins to neurodevelopmental, neuropsychiatric, and neurodegenerative diseases. In this review, we describe the way in which several proteins that participate in cell adhesion, scaffolding, exocytosis, and neurotransmitter reception from presynaptic and postsynaptic compartments, mainly from excitatory synapses, have been associated with several synaptopathies, and we relate their functions to the disease phenotype. |
| format | Article |
| id | doaj-art-79f7098fa58f453692f815ef2c7105cf |
| institution | OA Journals |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-79f7098fa58f453692f815ef2c7105cf2025-08-20T02:07:17ZengWileyNeural Plasticity2090-59041687-54432017-01-01201710.1155/2017/80817588081758Emerging Synaptic Molecules as Candidates in the Etiology of Neurological DisordersViviana I. Torres0Daniela Vallejo1Nibaldo C. Inestrosa2Centro de Envejecimiento y Regeneración (CARE), Departamento de Biología Celular y Molecular, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, ChileCentro de Envejecimiento y Regeneración (CARE), Departamento de Biología Celular y Molecular, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, ChileCentro de Envejecimiento y Regeneración (CARE), Departamento de Biología Celular y Molecular, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, ChileSynapses are complex structures that allow communication between neurons in the central nervous system. Studies conducted in vertebrate and invertebrate models have contributed to the knowledge of the function of synaptic proteins. The functional synapse requires numerous protein complexes with specialized functions that are regulated in space and time to allow synaptic plasticity. However, their interplay during neuronal development, learning, and memory is poorly understood. Accumulating evidence links synapse proteins to neurodevelopmental, neuropsychiatric, and neurodegenerative diseases. In this review, we describe the way in which several proteins that participate in cell adhesion, scaffolding, exocytosis, and neurotransmitter reception from presynaptic and postsynaptic compartments, mainly from excitatory synapses, have been associated with several synaptopathies, and we relate their functions to the disease phenotype.http://dx.doi.org/10.1155/2017/8081758 |
| spellingShingle | Viviana I. Torres Daniela Vallejo Nibaldo C. Inestrosa Emerging Synaptic Molecules as Candidates in the Etiology of Neurological Disorders Neural Plasticity |
| title | Emerging Synaptic Molecules as Candidates in the Etiology of Neurological Disorders |
| title_full | Emerging Synaptic Molecules as Candidates in the Etiology of Neurological Disorders |
| title_fullStr | Emerging Synaptic Molecules as Candidates in the Etiology of Neurological Disorders |
| title_full_unstemmed | Emerging Synaptic Molecules as Candidates in the Etiology of Neurological Disorders |
| title_short | Emerging Synaptic Molecules as Candidates in the Etiology of Neurological Disorders |
| title_sort | emerging synaptic molecules as candidates in the etiology of neurological disorders |
| url | http://dx.doi.org/10.1155/2017/8081758 |
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