Metaanalytic Approach to Evaluate Clinical Effectiveness of Infusion Succinnate-Containing Remaxol in Liver Pathologies of Diverse Genesis
Metaanalysis was applied to the published data on the randomized clinical trials of Remaxol in the treatment of various diseases associated with the liver injury: chronic hepatitis B and C, severe ethanol intoxication, drug-induced pathologies due to tuberculosis chemotherapy, leptospirosis, psorias...
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| Format: | Article |
| Language: | Russian |
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LLC "Publishing House OKI"
2020-05-01
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| Series: | Антибиотики и Химиотерапия |
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| Online Access: | https://www.antibiotics-chemotherapy.ru/jour/article/view/631 |
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| author | N. K. Mazina P. V. Mazin |
| author_facet | N. K. Mazina P. V. Mazin |
| author_sort | N. K. Mazina |
| collection | DOAJ |
| description | Metaanalysis was applied to the published data on the randomized clinical trials of Remaxol in the treatment of various diseases associated with the liver injury: chronic hepatitis B and C, severe ethanol intoxication, drug-induced pathologies due to tuberculosis chemotherapy, leptospirosis, psoriasis, tumor polychemotherapy. The database included information on 2250 patients. The total number of the patients of the control group (n=1099) were treated according to the routine schemes (active placebo) and that of the main group (n=1151) were additionally treated with Remaxol. Combination of the frequency characteristics of the positive outcomes (% of elimination of the main clinical symptoms and complications) in the patients of the reference groups allowed to estimate the general clinical efficacy of Remaxol, that was equal to 1.75 by the outcome frequency characteristics. The odds ratio of the positive outcomes equaled 5.3 [1.8; 17.0] and the number of the patients needed to treat (NPNT) equaled 8 [6; 14]. Therefore, the infusion Remaxol hepatoprotector based on succinic acid was shown to have statistically and clinally significant therapeutic efficacy in pharmacologic correction of the liver pathologies of diverse genesis. |
| format | Article |
| id | doaj-art-79ea54534746404aa95ebd3373582ea6 |
| institution | Kabale University |
| issn | 0235-2990 |
| language | Russian |
| publishDate | 2020-05-01 |
| publisher | LLC "Publishing House OKI" |
| record_format | Article |
| series | Антибиотики и Химиотерапия |
| spelling | doaj-art-79ea54534746404aa95ebd3373582ea62025-08-20T03:42:02ZrusLLC "Publishing House OKI"Антибиотики и Химиотерапия0235-29902020-05-016011-124349630Metaanalytic Approach to Evaluate Clinical Effectiveness of Infusion Succinnate-Containing Remaxol in Liver Pathologies of Diverse GenesisN. K. Mazina0P. V. Mazin1Kirov State Medical AcademyKirov State Medical AcademyMetaanalysis was applied to the published data on the randomized clinical trials of Remaxol in the treatment of various diseases associated with the liver injury: chronic hepatitis B and C, severe ethanol intoxication, drug-induced pathologies due to tuberculosis chemotherapy, leptospirosis, psoriasis, tumor polychemotherapy. The database included information on 2250 patients. The total number of the patients of the control group (n=1099) were treated according to the routine schemes (active placebo) and that of the main group (n=1151) were additionally treated with Remaxol. Combination of the frequency characteristics of the positive outcomes (% of elimination of the main clinical symptoms and complications) in the patients of the reference groups allowed to estimate the general clinical efficacy of Remaxol, that was equal to 1.75 by the outcome frequency characteristics. The odds ratio of the positive outcomes equaled 5.3 [1.8; 17.0] and the number of the patients needed to treat (NPNT) equaled 8 [6; 14]. Therefore, the infusion Remaxol hepatoprotector based on succinic acid was shown to have statistically and clinally significant therapeutic efficacy in pharmacologic correction of the liver pathologies of diverse genesis.https://www.antibiotics-chemotherapy.ru/jour/article/view/631remaxolmetaanalysishepatoprotectorsuccinic aciddrug-associated liver injuryclinical efficacyodds ratio |
| spellingShingle | N. K. Mazina P. V. Mazin Metaanalytic Approach to Evaluate Clinical Effectiveness of Infusion Succinnate-Containing Remaxol in Liver Pathologies of Diverse Genesis Антибиотики и Химиотерапия remaxol metaanalysis hepatoprotector succinic acid drug-associated liver injury clinical efficacy odds ratio |
| title | Metaanalytic Approach to Evaluate Clinical Effectiveness of Infusion Succinnate-Containing Remaxol in Liver Pathologies of Diverse Genesis |
| title_full | Metaanalytic Approach to Evaluate Clinical Effectiveness of Infusion Succinnate-Containing Remaxol in Liver Pathologies of Diverse Genesis |
| title_fullStr | Metaanalytic Approach to Evaluate Clinical Effectiveness of Infusion Succinnate-Containing Remaxol in Liver Pathologies of Diverse Genesis |
| title_full_unstemmed | Metaanalytic Approach to Evaluate Clinical Effectiveness of Infusion Succinnate-Containing Remaxol in Liver Pathologies of Diverse Genesis |
| title_short | Metaanalytic Approach to Evaluate Clinical Effectiveness of Infusion Succinnate-Containing Remaxol in Liver Pathologies of Diverse Genesis |
| title_sort | metaanalytic approach to evaluate clinical effectiveness of infusion succinnate containing remaxol in liver pathologies of diverse genesis |
| topic | remaxol metaanalysis hepatoprotector succinic acid drug-associated liver injury clinical efficacy odds ratio |
| url | https://www.antibiotics-chemotherapy.ru/jour/article/view/631 |
| work_keys_str_mv | AT nkmazina metaanalyticapproachtoevaluateclinicaleffectivenessofinfusionsuccinnatecontainingremaxolinliverpathologiesofdiversegenesis AT pvmazin metaanalyticapproachtoevaluateclinicaleffectivenessofinfusionsuccinnatecontainingremaxolinliverpathologiesofdiversegenesis |