Is Infection Associated With Ulcerative Colitis Activity?
Objectives Epidemiological studies have shown an inverse association between Helicobacter pylori infection and ulcerative colitis (UC). In this study, we investigated the protective effects of H. pylori infection on the severity of UC. Methods This single-center study included 316 patients with newl...
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Korean College of Helicobacter and Upper Gastrointestinal Research
2024-03-01
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| Series: | The Korean Journal of Helicobacter and Upper Gastrointestinal Research |
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| Online Access: | http://helicojournal.org/upload/pdf/kjhugr-2023-0045.pdf |
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| author | Ayoung Lee Jung Wan Choe Sung Woo Jung Jae Youn Park Ik Yoon Seung Young Kim |
| author_facet | Ayoung Lee Jung Wan Choe Sung Woo Jung Jae Youn Park Ik Yoon Seung Young Kim |
| author_sort | Ayoung Lee |
| collection | DOAJ |
| description | Objectives Epidemiological studies have shown an inverse association between Helicobacter pylori infection and ulcerative colitis (UC). In this study, we investigated the protective effects of H. pylori infection on the severity of UC. Methods This single-center study included 316 patients with newly diagnosed UC based on findings of colonoscopy and upper endoscopy for H. pylori evaluation between January 1994 and December 2015. Patients’ medical records were retrospectively reviewed, and severity of UC was assessed based on endoscopic findings, clinical symptoms, treatment regimens, and Mayo scores. Results The prevalence of H. pylori infection in patients with UC was 74/316 (23.4%). Based on upper endoscopic findings, the percentage of patients with duodenal ulcers was significantly higher in the H. pylori positive group than that in the H. pylori negative group (27.0% vs. 11.6%, p=0.022). Disease extent and endoscopic severity showed no significant intergroup difference (p=0.765 and p=0.803, respectively). Endoscopic severity was unaffected by the H. pylori infection status, based on the extent of endoscopically documented disease and endoscopic findings. Furthermore, UC-related symptom severity assessed on the basis of stool frequency, rectal bleeding severity, and rate of admission necessitated by UC aggravation was not associated with H. pylori infection (p=0.185, 0.144, and 0.182, respectively). Use of steroids as induction therapy for severe UC did not differ with regard to H. pylori infection (p=0.327). No intergroup difference was observed in disease severity of UC classified using the Mayo score (p=0.323). Conclusions H. pylori infection was detected in approximately 25.0% of patients with UC. However, the H. pylori infection status was not associated with the severity of UC based on endoscopic disease activity, patients’ symptoms, steroid use, or the Mayo clinic score. |
| format | Article |
| id | doaj-art-79e852891d2049b4ace87feda1174d00 |
| institution | Kabale University |
| issn | 1738-3331 |
| language | English |
| publishDate | 2024-03-01 |
| publisher | Korean College of Helicobacter and Upper Gastrointestinal Research |
| record_format | Article |
| series | The Korean Journal of Helicobacter and Upper Gastrointestinal Research |
| spelling | doaj-art-79e852891d2049b4ace87feda1174d002025-08-20T03:33:49ZengKorean College of Helicobacter and Upper Gastrointestinal ResearchThe Korean Journal of Helicobacter and Upper Gastrointestinal Research1738-33312024-03-01241525710.7704/kjhugr.2023.0045822Is Infection Associated With Ulcerative Colitis Activity?Ayoung Lee0Jung Wan Choe1Sung Woo JungJae Youn Park2Ik Yoon3Seung Young Kim4 Division of Gastroenterology, Department of Internal Medicine, Korea University College of Medicine, Ansan, Korea Division of Gastroenterology, Department of Internal Medicine, Korea University College of Medicine, Ansan, Korea Division of Gastroenterology, Department of Internal Medicine, Korea University College of Medicine, Ansan, Korea Division of Gastroenterology, Department of Internal Medicine, Korea University College of Medicine, Ansan, Korea Division of Gastroenterology, Department of Internal Medicine, Korea University College of Medicine, Ansan, KoreaObjectives Epidemiological studies have shown an inverse association between Helicobacter pylori infection and ulcerative colitis (UC). In this study, we investigated the protective effects of H. pylori infection on the severity of UC. Methods This single-center study included 316 patients with newly diagnosed UC based on findings of colonoscopy and upper endoscopy for H. pylori evaluation between January 1994 and December 2015. Patients’ medical records were retrospectively reviewed, and severity of UC was assessed based on endoscopic findings, clinical symptoms, treatment regimens, and Mayo scores. Results The prevalence of H. pylori infection in patients with UC was 74/316 (23.4%). Based on upper endoscopic findings, the percentage of patients with duodenal ulcers was significantly higher in the H. pylori positive group than that in the H. pylori negative group (27.0% vs. 11.6%, p=0.022). Disease extent and endoscopic severity showed no significant intergroup difference (p=0.765 and p=0.803, respectively). Endoscopic severity was unaffected by the H. pylori infection status, based on the extent of endoscopically documented disease and endoscopic findings. Furthermore, UC-related symptom severity assessed on the basis of stool frequency, rectal bleeding severity, and rate of admission necessitated by UC aggravation was not associated with H. pylori infection (p=0.185, 0.144, and 0.182, respectively). Use of steroids as induction therapy for severe UC did not differ with regard to H. pylori infection (p=0.327). No intergroup difference was observed in disease severity of UC classified using the Mayo score (p=0.323). Conclusions H. pylori infection was detected in approximately 25.0% of patients with UC. However, the H. pylori infection status was not associated with the severity of UC based on endoscopic disease activity, patients’ symptoms, steroid use, or the Mayo clinic score.http://helicojournal.org/upload/pdf/kjhugr-2023-0045.pdfinflammatory bowel diseaseulcerative colitis |
| spellingShingle | Ayoung Lee Jung Wan Choe Sung Woo Jung Jae Youn Park Ik Yoon Seung Young Kim Is Infection Associated With Ulcerative Colitis Activity? The Korean Journal of Helicobacter and Upper Gastrointestinal Research inflammatory bowel disease ulcerative colitis |
| title | Is Infection Associated With Ulcerative Colitis Activity? |
| title_full | Is Infection Associated With Ulcerative Colitis Activity? |
| title_fullStr | Is Infection Associated With Ulcerative Colitis Activity? |
| title_full_unstemmed | Is Infection Associated With Ulcerative Colitis Activity? |
| title_short | Is Infection Associated With Ulcerative Colitis Activity? |
| title_sort | is infection associated with ulcerative colitis activity |
| topic | inflammatory bowel disease ulcerative colitis |
| url | http://helicojournal.org/upload/pdf/kjhugr-2023-0045.pdf |
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