Dual targeting of TAM receptors Tyro3, Axl, and MerTK: Role in tumors and the tumor immune microenvironment
In both normal and tumor tissues, receptor tyrosine kinases (RTKs) may be pleiotropically expressed. The RTKs not only regulate ordinary cellular processes, including proliferation, survival, adhesion, and migration, but also have a critical role in the development of many types of cancer. The Tyro3...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2021-01-01
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| Series: | Tzu Chi Medical Journal |
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| Online Access: | http://www.tcmjmed.com/article.asp?issn=1016-3190;year=2021;volume=33;issue=3;spage=250;epage=256;aulast=Wang |
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| _version_ | 1849325126211862528 |
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| author | Kai-Hung Wang Dah-Ching Ding |
| author_facet | Kai-Hung Wang Dah-Ching Ding |
| author_sort | Kai-Hung Wang |
| collection | DOAJ |
| description | In both normal and tumor tissues, receptor tyrosine kinases (RTKs) may be pleiotropically expressed. The RTKs not only regulate ordinary cellular processes, including proliferation, survival, adhesion, and migration, but also have a critical role in the development of many types of cancer. The Tyro3, Axl, and MerTK (TAM) family of RTKs (Tyro3, Axl, and MerTK) plays a pleiotropic role in phagocytosis, inflammation, and normal cellular processes. In this article, we highlight the cellular activities of TAM receptors and discuss their roles in cancer and immune cells. We also discuss cancer therapies that target TAM receptors. Further research is needed to elucidate the function of TAM receptors in immune cells toward the development of new targeted immunotherapies for cancer. |
| format | Article |
| id | doaj-art-79e5cd7e90404c238a54c2eb89c1e936 |
| institution | Kabale University |
| issn | 1016-3190 2223-8956 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Tzu Chi Medical Journal |
| spelling | doaj-art-79e5cd7e90404c238a54c2eb89c1e9362025-08-20T03:48:30ZengWolters Kluwer Medknow PublicationsTzu Chi Medical Journal1016-31902223-89562021-01-0133325025610.4103/tcmj.tcmj_129_20Dual targeting of TAM receptors Tyro3, Axl, and MerTK: Role in tumors and the tumor immune microenvironmentKai-Hung WangDah-Ching DingIn both normal and tumor tissues, receptor tyrosine kinases (RTKs) may be pleiotropically expressed. The RTKs not only regulate ordinary cellular processes, including proliferation, survival, adhesion, and migration, but also have a critical role in the development of many types of cancer. The Tyro3, Axl, and MerTK (TAM) family of RTKs (Tyro3, Axl, and MerTK) plays a pleiotropic role in phagocytosis, inflammation, and normal cellular processes. In this article, we highlight the cellular activities of TAM receptors and discuss their roles in cancer and immune cells. We also discuss cancer therapies that target TAM receptors. Further research is needed to elucidate the function of TAM receptors in immune cells toward the development of new targeted immunotherapies for cancer.http://www.tcmjmed.com/article.asp?issn=1016-3190;year=2021;volume=33;issue=3;spage=250;epage=256;aulast=Wangaxlmertktyro3axland mertk receptorstumor immune microenvironmenttyro3 |
| spellingShingle | Kai-Hung Wang Dah-Ching Ding Dual targeting of TAM receptors Tyro3, Axl, and MerTK: Role in tumors and the tumor immune microenvironment Tzu Chi Medical Journal axl mertk tyro3 axl and mertk receptors tumor immune microenvironment tyro3 |
| title | Dual targeting of TAM receptors Tyro3, Axl, and MerTK: Role in tumors and the tumor immune microenvironment |
| title_full | Dual targeting of TAM receptors Tyro3, Axl, and MerTK: Role in tumors and the tumor immune microenvironment |
| title_fullStr | Dual targeting of TAM receptors Tyro3, Axl, and MerTK: Role in tumors and the tumor immune microenvironment |
| title_full_unstemmed | Dual targeting of TAM receptors Tyro3, Axl, and MerTK: Role in tumors and the tumor immune microenvironment |
| title_short | Dual targeting of TAM receptors Tyro3, Axl, and MerTK: Role in tumors and the tumor immune microenvironment |
| title_sort | dual targeting of tam receptors tyro3 axl and mertk role in tumors and the tumor immune microenvironment |
| topic | axl mertk tyro3 axl and mertk receptors tumor immune microenvironment tyro3 |
| url | http://www.tcmjmed.com/article.asp?issn=1016-3190;year=2021;volume=33;issue=3;spage=250;epage=256;aulast=Wang |
| work_keys_str_mv | AT kaihungwang dualtargetingoftamreceptorstyro3axlandmertkroleintumorsandthetumorimmunemicroenvironment AT dahchingding dualtargetingoftamreceptorstyro3axlandmertkroleintumorsandthetumorimmunemicroenvironment |