Comparative Analysis of γ-Cyclodextrin, Perilla Oil, and Their Inclusion Complexes on Liver Injury and Dyslipidemia Associated with Elevated Gastrointestinal 12-Hydroxylated Bile Acid Levels

Comparative Analysis of γ-Cyclodextrin, Perilla Oil, and Their Inclusion Complexes on Liver Injury and Dyslipidemia Associated with Elevated Gastrointestinal 12-Hydroxylated Bile Acid Levels

Our previous study demonstrated that γ-cyclodextrin (γ-CD)–perilla oil inclusion complexes increase plasma α-linolenic acid and eicosapentaenoic acid levels in healthy rats without adverse effects. The present study examined the effects of perilla oil, γ-CD, and their inclusion complexes on rats fed...

Full description

Saved in:

Bibliographic Details
Main Authors:	Keisuke Yoshikiyo, Hidehisa Shimizu, Edward G. Nagato, Satoshi Ishizuka, Tatsuyuki Yamamoto
Format:	Article
Language:	English
Published:	MDPI AG 2025-01-01
Series:	Molecules
Subjects:	Perilla oil γ-cyclodextrin inclusion complex 12-hydroxylated bile acids cholic acid α-linolenic acid
Online Access:	https://www.mdpi.com/1420-3049/30/2/281
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

The clinical and biochemical effectiveness and safety of cholic acid treatment for bile acid synthesis defects: a systematic review
by: Yasmin Polak, et al.
Published: (2024-12-01)

Influence de l’hydroxypropyl-β-Cyclodextrine et de l’hydroxypropyl-γ-Cyclodextrine sur la solubilité aqueuse de l’acide ellagique
by: Isaie Nyamba, et al.
Published: (2024-12-01)

Recent Advances and Challenges in the Production of Hydroxylated Natural Products Using Microorganisms
by: Chang Sun, et al.
Published: (2024-11-01)

Exploring the genotypic potential of perilla (Perilla frutescens L.) for climate-resilient agriculture in the North Eastern Himalayas
by: Meraj Alam Ansari, et al.
Published: (2025-02-01)

Assessing the Antioxidant, Hepatoprotective, and Iron-Chelating Potential of <i>Perilla frutescens</i> Seed
by: Sirichatnach Pakdeepromma, et al.
Published: (2025-04-01)

Effects of Perilla Seed Oil on Blood Lipids, Oxidative Stress, and Inflammation in Hyperlipidemic Rats
by: Suwajee Pothinam, et al.
Published: (2025-04-01)

Analysis of cholic acid amides by high-performance liquid chromatography
by: V. I. Gusarov, et al.
Published: (2012-12-01)

Quercetin‐Driven Akkermansia Muciniphila Alleviates Obesity by Modulating Bile Acid Metabolism via an ILA/m6A/CYP8B1 Signaling
by: Jiaqi Liu, et al.
Published: (2025-03-01)

Bile acid receptors regulate the role of intestinal macrophages in inflammatory bowel disease
by: Hongjie Yang, et al.
Published: (2025-06-01)

Synthesis of polycationic amphiphiles on the basis of cholic acid
by: V. N. Sokolik, et al.
Published: (2010-12-01)

Polyunsaturated Fatty Acids from <i>Thamnidium elegans</i> and <i>Mortierella alpina</i> Suppress Prostate Cancer Cell Proliferation and Migration
by: Georgios Kalampounias, et al.
Published: (2024-11-01)

Cholic acid as a treatment for cerebrotendinous xanthomatosis: a comprehensive review of safety and efficacy
by: Gary Pasternack, et al.
Published: (2025-07-01)

Multifaceted Interactions Between Bile Acids, Their Receptors, and MASH: From Molecular Mechanisms to Clinical Therapeutics
by: Xuan Tang, et al.
Published: (2025-07-01)

Differential roles of individual bile acid in physiology and disease
by: Mingjie Fan, et al.
Published: (2025-08-01)

Formation of secondary allo-bile acids by novel enzymes from gut Firmicutes
by: Jae Won Lee, et al.
Published: (2022-12-01)

Synthetic Applications of Amino Acid Derived Aldehydes in Asymmetric Hydroxylation Reactions Using Nitrosobenzene
by: Vipin Kumar Jain, et al.
Published: (2025-01-01)

Bile acids affect intestinal barrier function through FXR and TGR5
by: Guangyao Song, et al.
Published: (2025-07-01)

Perilla Seed Oil and Protein: Composition, Health Benefits, and Potential Applications in Functional Foods
by: Lijun Guan, et al.
Published: (2024-11-01)

Polyphenols of <i>Perilla frutescens</i> of the family Lamiaceae identified by tandem mass spectrometry
by: M. P. Razgonova, et al.
Published: (2022-11-01)

Evaluation of Fasting Bile Acid Levels in Pregnant Women Diagnosed with Hyperemesis Gravidarum
by: Ayca Kubat Kucukyurt, et al.
Published: (2024-09-01)

Conjugated bile acids are elevated in severe calcific aortic valve stenosis
by: Hannah Zhang, et al.
Published: (2025-06-01)

Ruminococcus gnavus and Biofilm Markers in Feces From Primary Bile Acid Diarrhea Patients Indicate New Disease Mechanisms and Potential for Diagnostic Testing
by: Evette B.M. Hillman, et al.
Published: (2025-01-01)

Enhancement of water radiolysis in the presence of nanodiamond sensitizers: Insights from interfacial hydroxyl radical formation under X-ray irradiation
by: Bowen Zhang, et al.
Published: (2025-07-01)

Pathogenic and therapeutic role of bile acids at reflux-gastritis
by: T. L. Lapina, et al.
Published: (2015-03-01)

Dysregulation of bile acid metabolism in patients with colorectal cancer
by: Su-Mi Lee, et al.
Published: (2025-08-01)

Microbiome-derived bile acids as endogenous regenerative mediators in liver repair
by: Surya Nath Pandey, et al.
Published: (2025-12-01)

Alpha-Linolenic Acid Attenuates Inflammatory Response in LPS-stimulated Macrophages by Regulating TLR4/MyD88/NF-κB Signaling Pathway
by: Ruixin CAI, et al.
Published: (2025-01-01)

Taurine-conjugated bile acids are the predominant form in hens and have potential impact on lipid metabolism in the liver
by: Wen-Yuan Yang, et al.
Published: (2023-12-01)

Bile Acids and Their Value for Central Nervous System
by: Yu. O. Shulpekova, et al.
Published: (2022-01-01)

The Effect of Cord Blood Bile Acid Levels on the Meconium Passage in Utero in Normal Pregnancies
by: Saynur Sarıcı Yılmaz, et al.
Published: (2015-08-01)

Synthesis of two isomers of 3-amino-7α-12α-dihydroxy-5β-cholanic acid
by: D. O. Barsuk, et al.
Published: (2015-04-01)

Alterations of bile acid metabolism in patients with functional bowel disorders: a case-control study
by: Serhii Polishchuk, et al.
Published: (2023-11-01)

Analysis of conjugated linolenic acid from plant seeds
by: YUAN Gao-feng, et al.
Published: (2011-05-01)

Synthesis of (9Z, 12E)-, (9E, 12Z)-[1-<sup>14</sup>C]-linoleic acid, (9Z, 12Z, 15E)-, (9E, 12Z, 15Z)-[1-<sup>14</sup>C]-linolenic acid and (5Z, 8Z, 11Z, 14E)-[1-<sup>14</sup>C]-arachidonic acid
by: Thierry Enard, et al.
Published: (1996-04-01)

AKR1D1 and CFTR homozygous variants in an infant with combined bile acid synthesis defect and cystic fibrosis: first case report and management plan
by: Nehal M. Elkoofy, et al.
Published: (2025-08-01)

High-concentrate diet decreases lamb fatty acid contents by regulating bile acid composition
by: Kaizhi Zheng, et al.
Published: (2024-12-01)

Determination of antioxidant and immune responses with bile acids supplementation in geese
by: Jianwen CAO, et al.
Published: (2024-12-01)

Effects of supplementing bile acids on the production performance, fatty acid and bile acid composition, and gut microbiota in transition dairy cows
by: Lei Li, et al.
Published: (2025-06-01)

The influence of feed supplementation with linseed oil and linseed extrudate on fatty acid profile in goat yoghurt drinks
by: Markéta Borková, et al.
Published: (2018-01-01)

EFFECT OF USING FLAXSEED OIL SOURCE OF OMEGA-3 ACIDS AS A PARTIAL REPLACEMENT FOR MILK FAT IN THE CHEMICAL AND PHYSICAL PROPERTIES IN ICE CREAM
by: Y. Aladwani, et al.
Published: (2018-03-01)