Clinical science effects of different mydriatics on retinal and choroidal parameters in healthy adults observed by widefield swept-source optical coherence tomography
Purpose To assess retinal and choroidal changes following rapid mydriasis in healthy adults.Methods Seventy-one volunteers (71 right eyes) participated in a prospective randomised controlled trial. They were divided into two groups: tropicamide (n=36) and a mixture (tropicamide:phenylephrine=1:1, n=...
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| Language: | English |
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BMJ Publishing Group
2025-07-01
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| Series: | BMJ Open Ophthalmology |
| Online Access: | https://bmjophth.bmj.com/content/10/1/e001963.full |
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| author | Jianmin Shang Xingtao Zhou Tian Han Yuliang Wang Huo Li Xiaoliao Peng Zhuoyi Chen Yangyi Huang |
| author_facet | Jianmin Shang Xingtao Zhou Tian Han Yuliang Wang Huo Li Xiaoliao Peng Zhuoyi Chen Yangyi Huang |
| author_sort | Jianmin Shang |
| collection | DOAJ |
| description | Purpose To assess retinal and choroidal changes following rapid mydriasis in healthy adults.Methods Seventy-one volunteers (71 right eyes) participated in a prospective randomised controlled trial. They were divided into two groups: tropicamide (n=36) and a mixture (tropicamide:phenylephrine=1:1, n=35) groups. Ophthalmic examinations included visual acuity, intraocular pressure and axial length measurements. Ultra-widefield swept-source optical coherence tomography angiography was used to assess retinal and choroidal parameters before and after mydriasis. This technique covers a 24×20 mm² area, allowing for non-invasive, simultaneous structural and haemodynamic assessment of retinal and choroidal regions.Results Both central (tropicamide: 33.3%; mixture: 22.22%) and mid-peripheral (tropicamide: 28.47%; mixture: 36.81%) retinas thickened slightly postmydriasis (p<0.05, false discovery rate (FDR) corrected). Specifically, thickening primarily occurred in the temporal (tropicamide: 25.61%; mixture: 34.31%) and inferior (tropicamide: 50.00%; mixture: 35.29%) mid-peripheral regions. Outer retinal layer thickening correlated positively with overall retinal thickness in both groups (tropicamide: r=0.71, p<0.001; mixture: r=0.74, p<0.001). Choroidal stroma volume increased in 18 regions post-tropicamide treatment and in two regions postmixture treatment (p<0.05, FDR corrected). However, no significant differences were found in retinal vascular density, choroidal thickness, vascular density or matrix between the two groups premydriatic and postmydriatic administration (p>0.05, FDR corrected).Conclusions Rapid mydriasis causes slight retinal thickening, the slight change in the outer layer, particularly in the temporal and inferior regions. There were no significant changes in the choroid parameters following mydriasis, except for choroidal stroma volume. The limitation of this study was the small sample size and the absence of a control group. |
| format | Article |
| id | doaj-art-79e1c5f70b2046518daa99b217bb3bf1 |
| institution | Kabale University |
| issn | 2397-3269 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open Ophthalmology |
| spelling | doaj-art-79e1c5f70b2046518daa99b217bb3bf12025-08-20T03:28:14ZengBMJ Publishing GroupBMJ Open Ophthalmology2397-32692025-07-0110110.1136/bmjophth-2024-001963Clinical science effects of different mydriatics on retinal and choroidal parameters in healthy adults observed by widefield swept-source optical coherence tomographyJianmin Shang0Xingtao Zhou1Tian Han2Yuliang Wang3Huo Li4Xiaoliao Peng5Zhuoyi Chen6Yangyi Huang7Department of Ophthalmology, Eye and ENT Hospital of Fudan University, Myopia Key Laboratory of the Health Ministry Shanghai, Shanghai, ChinaDepartment of Ophthalmology, Fudan University, Shanghai, ChinaDepartment of Ophthalmology, Fudan University, Shanghai, ChinaDepartment of Ophthalmology and Vision Science, Fudan University Eye Ear Nose and Throat Hospital, Shanghai, ChinaDepartment of Electronic Engineering, Tsinghua University, Beijing, ChinaDepartment of Ophthalmology, Fudan University, Shanghai, ChinaOphthalmology, Eye and ENT Hospital of Fudan University, Shanghai, ChinaDepartment of Ophthalmology, Eye, Ear, Nose and Throat Hospital, Fudan University, Shanghai, ChinaPurpose To assess retinal and choroidal changes following rapid mydriasis in healthy adults.Methods Seventy-one volunteers (71 right eyes) participated in a prospective randomised controlled trial. They were divided into two groups: tropicamide (n=36) and a mixture (tropicamide:phenylephrine=1:1, n=35) groups. Ophthalmic examinations included visual acuity, intraocular pressure and axial length measurements. Ultra-widefield swept-source optical coherence tomography angiography was used to assess retinal and choroidal parameters before and after mydriasis. This technique covers a 24×20 mm² area, allowing for non-invasive, simultaneous structural and haemodynamic assessment of retinal and choroidal regions.Results Both central (tropicamide: 33.3%; mixture: 22.22%) and mid-peripheral (tropicamide: 28.47%; mixture: 36.81%) retinas thickened slightly postmydriasis (p<0.05, false discovery rate (FDR) corrected). Specifically, thickening primarily occurred in the temporal (tropicamide: 25.61%; mixture: 34.31%) and inferior (tropicamide: 50.00%; mixture: 35.29%) mid-peripheral regions. Outer retinal layer thickening correlated positively with overall retinal thickness in both groups (tropicamide: r=0.71, p<0.001; mixture: r=0.74, p<0.001). Choroidal stroma volume increased in 18 regions post-tropicamide treatment and in two regions postmixture treatment (p<0.05, FDR corrected). However, no significant differences were found in retinal vascular density, choroidal thickness, vascular density or matrix between the two groups premydriatic and postmydriatic administration (p>0.05, FDR corrected).Conclusions Rapid mydriasis causes slight retinal thickening, the slight change in the outer layer, particularly in the temporal and inferior regions. There were no significant changes in the choroid parameters following mydriasis, except for choroidal stroma volume. The limitation of this study was the small sample size and the absence of a control group.https://bmjophth.bmj.com/content/10/1/e001963.full |
| spellingShingle | Jianmin Shang Xingtao Zhou Tian Han Yuliang Wang Huo Li Xiaoliao Peng Zhuoyi Chen Yangyi Huang Clinical science effects of different mydriatics on retinal and choroidal parameters in healthy adults observed by widefield swept-source optical coherence tomography BMJ Open Ophthalmology |
| title | Clinical science effects of different mydriatics on retinal and choroidal parameters in healthy adults observed by widefield swept-source optical coherence tomography |
| title_full | Clinical science effects of different mydriatics on retinal and choroidal parameters in healthy adults observed by widefield swept-source optical coherence tomography |
| title_fullStr | Clinical science effects of different mydriatics on retinal and choroidal parameters in healthy adults observed by widefield swept-source optical coherence tomography |
| title_full_unstemmed | Clinical science effects of different mydriatics on retinal and choroidal parameters in healthy adults observed by widefield swept-source optical coherence tomography |
| title_short | Clinical science effects of different mydriatics on retinal and choroidal parameters in healthy adults observed by widefield swept-source optical coherence tomography |
| title_sort | clinical science effects of different mydriatics on retinal and choroidal parameters in healthy adults observed by widefield swept source optical coherence tomography |
| url | https://bmjophth.bmj.com/content/10/1/e001963.full |
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