Synthesis of chitosan grafted with aminomethyl zinc phthalocyanine for photodynamic therapy
This paper reports the synthesis of a substituted aminomethyl zinc phthalocyanine (AmPcZn) and its covalent grafting onto chitosan via an ethyl chloroformate-mediated reaction. Chitosan-based copolymers containing 10%, 20%, 30%, and 60% (w/w) AmPcZn were successfully obtained. The chemical structure...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Academy of Sciences of Moldova, Institute of Chemistry
2025-07-01
|
| Series: | Chemistry Journal of Moldova: General, Industrial and Ecological Chemistry |
| Subjects: | |
| Online Access: |
http://cjm.ichem.md/synthesis-of-chitosan-grafted-with-aminomethyl-zinc-phthalocyanine-for-photodynamic-therapy
|
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849319279086796800 |
|---|---|
| author | Stefan Robu Tamara Potlog Ion Bulimestru Ion Lungu Olga Sadohina Alexandrina Druta Petru Bulmaga Iacob Gutu |
| author_facet | Stefan Robu Tamara Potlog Ion Bulimestru Ion Lungu Olga Sadohina Alexandrina Druta Petru Bulmaga Iacob Gutu |
| author_sort | Stefan Robu |
| collection | DOAJ |
| description | This paper reports the synthesis of a substituted aminomethyl zinc phthalocyanine (AmPcZn) and its covalent grafting onto chitosan via an ethyl chloroformate-mediated reaction. Chitosan-based copolymers containing 10%, 20%, 30%, and 60% (w/w) AmPcZn were successfully obtained. The chemical structure of the synthesized AmPcZn was confirmed by 1H-NMR spectroscopy and elemental analysis, which were consistent with the expected molecular composition. The grafting reaction and structural integrity of the resulting copolymers were investigated using Fourier-transform infrared (FTIR) and UV-Vis spectroscopies. FTIR spectra revealed characteristic amide and carbonyl stretching bands, confirming covalent bond formation between chitosan and AmPcZn. UV-Vis measurements showed a concentration-dependent increase in absorbance and a typical splitting of the Q-band with band at 605 nm and 715 nm, indicating the successful incorporation of the phthalocyanine moiety into the polymeric matrix. |
| format | Article |
| id | doaj-art-79e1b96b62ba44eea871e4104993e42d |
| institution | Kabale University |
| issn | 1857-1727 2345-1688 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Academy of Sciences of Moldova, Institute of Chemistry |
| record_format | Article |
| series | Chemistry Journal of Moldova: General, Industrial and Ecological Chemistry |
| spelling | doaj-art-79e1b96b62ba44eea871e4104993e42d2025-08-20T03:50:32ZengAcademy of Sciences of Moldova, Institute of ChemistryChemistry Journal of Moldova: General, Industrial and Ecological Chemistry1857-17272345-16882025-07-01201626810.19261/cjm.2025.12171217Synthesis of chitosan grafted with aminomethyl zinc phthalocyanine for photodynamic therapyStefan Robu0Tamara Potlog1Ion Bulimestru2Ion Lungu3Olga Sadohina4Alexandrina Druta5Petru Bulmaga6Iacob Gutu7 Organic/Inorganic Materials in Optoelectronics, Moldova State University, 60, Alexei Mateevici str., Chisinau MD-2009, Republic of Moldova Organic/Inorganic Materials in Optoelectronics, Moldova State University, 60, Alexei Mateevici str., Chisinau MD-2009, Republic of Moldova Organic/Inorganic Materials in Optoelectronics, Moldova State University, 60, Alexei Mateevici str., Chisinau MD-2009, Republic of Moldova Organic/Inorganic Materials in Optoelectronics, Moldova State University, 60, Alexei Mateevici str., Chisinau MD-2009, Republic of Moldova Organic/Inorganic Materials in Optoelectronics, Moldova State University, 60, Alexei Mateevici str., Chisinau MD-2009, Republic of Moldova Organic/Inorganic Materials in Optoelectronics, Moldova State University, 60, Alexei Mateevici str., Chisinau MD-2009, Republic of Moldova Organic/Inorganic Materials in Optoelectronics, Moldova State University, 60, Alexei Mateevici str., Chisinau MD-2009, Republic of Moldova Organic/Inorganic Materials in Optoelectronics, Moldova State University, 60, Alexei Mateevici str., Chisinau MD-2009, Republic of Moldova This paper reports the synthesis of a substituted aminomethyl zinc phthalocyanine (AmPcZn) and its covalent grafting onto chitosan via an ethyl chloroformate-mediated reaction. Chitosan-based copolymers containing 10%, 20%, 30%, and 60% (w/w) AmPcZn were successfully obtained. The chemical structure of the synthesized AmPcZn was confirmed by 1H-NMR spectroscopy and elemental analysis, which were consistent with the expected molecular composition. The grafting reaction and structural integrity of the resulting copolymers were investigated using Fourier-transform infrared (FTIR) and UV-Vis spectroscopies. FTIR spectra revealed characteristic amide and carbonyl stretching bands, confirming covalent bond formation between chitosan and AmPcZn. UV-Vis measurements showed a concentration-dependent increase in absorbance and a typical splitting of the Q-band with band at 605 nm and 715 nm, indicating the successful incorporation of the phthalocyanine moiety into the polymeric matrix. http://cjm.ichem.md/synthesis-of-chitosan-grafted-with-aminomethyl-zinc-phthalocyanine-for-photodynamic-therapy znpc derivativechitosangrafting reactionuv-vis spectroscopyftir spectroscopy |
| spellingShingle | Stefan Robu Tamara Potlog Ion Bulimestru Ion Lungu Olga Sadohina Alexandrina Druta Petru Bulmaga Iacob Gutu Synthesis of chitosan grafted with aminomethyl zinc phthalocyanine for photodynamic therapy Chemistry Journal of Moldova: General, Industrial and Ecological Chemistry znpc derivative chitosan grafting reaction uv-vis spectroscopy ftir spectroscopy |
| title | Synthesis of chitosan grafted with aminomethyl zinc phthalocyanine for photodynamic therapy |
| title_full | Synthesis of chitosan grafted with aminomethyl zinc phthalocyanine for photodynamic therapy |
| title_fullStr | Synthesis of chitosan grafted with aminomethyl zinc phthalocyanine for photodynamic therapy |
| title_full_unstemmed | Synthesis of chitosan grafted with aminomethyl zinc phthalocyanine for photodynamic therapy |
| title_short | Synthesis of chitosan grafted with aminomethyl zinc phthalocyanine for photodynamic therapy |
| title_sort | synthesis of chitosan grafted with aminomethyl zinc phthalocyanine for photodynamic therapy |
| topic | znpc derivative chitosan grafting reaction uv-vis spectroscopy ftir spectroscopy |
| url |
http://cjm.ichem.md/synthesis-of-chitosan-grafted-with-aminomethyl-zinc-phthalocyanine-for-photodynamic-therapy
|
| work_keys_str_mv | AT stefanrobu synthesisofchitosangraftedwithaminomethylzincphthalocyanineforphotodynamictherapy AT tamarapotlog synthesisofchitosangraftedwithaminomethylzincphthalocyanineforphotodynamictherapy AT ionbulimestru synthesisofchitosangraftedwithaminomethylzincphthalocyanineforphotodynamictherapy AT ionlungu synthesisofchitosangraftedwithaminomethylzincphthalocyanineforphotodynamictherapy AT olgasadohina synthesisofchitosangraftedwithaminomethylzincphthalocyanineforphotodynamictherapy AT alexandrinadruta synthesisofchitosangraftedwithaminomethylzincphthalocyanineforphotodynamictherapy AT petrubulmaga synthesisofchitosangraftedwithaminomethylzincphthalocyanineforphotodynamictherapy AT iacobgutu synthesisofchitosangraftedwithaminomethylzincphthalocyanineforphotodynamictherapy |