Granulocyte Macrophage Colony Stimulating Factor Supplementation in Culture Media for Subfertile Women Undergoing Assisted Reproduction Technologies: A Systematic Review
Granulocyte macrophage colony stimulating factor (GM-CSF) is a cytokine/growth factor produced by epithelial cells that exerts embryotrophic effects during the early stages of embryo development. We performed a systematic review, and six studies that were performed in humans undergoing assisted repr...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2013/704967 |
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| author | Charalampos Siristatidis Paraskevi Vogiatzi George Salamalekis Maria Creatsa Nikos Vrachnis Demián Glujovsky Zoe Iliodromiti Charalampos Chrelias |
| author_facet | Charalampos Siristatidis Paraskevi Vogiatzi George Salamalekis Maria Creatsa Nikos Vrachnis Demián Glujovsky Zoe Iliodromiti Charalampos Chrelias |
| author_sort | Charalampos Siristatidis |
| collection | DOAJ |
| description | Granulocyte macrophage colony stimulating factor (GM-CSF) is a cytokine/growth factor produced by epithelial cells that exerts embryotrophic effects during the early stages of embryo development. We performed a systematic review, and six studies that were performed in humans undergoing assisted reproduction technologies (ART) were located. We wanted to evaluate if embryo culture media supplementation with GM-CSF could improve success rates. As the type of studies and the outcome parameters investigated were heterogeneous, we decided not to perform a meta-analysis. Most of them had a trend favoring the supplementation with GM-CSF, when outcomes were measured in terms of increased percentage of good-quality embryos reaching the blastocyst stage, improved hatching initiation and number of cells in the blastocyst, and reduction of cell death. However, no statistically significant differences were found in implantation and pregnancy rates in all apart from one large multicenter trial, which reported favorable outcomes, in terms of implantation and live birth rates. We propose properly conducted and adequately powered randomized controlled trials (RCTs) to further validate and extrapolate the current findings with the live birth rate to be the primary outcome measure. |
| format | Article |
| id | doaj-art-79dd9a4a52a548b6bbc293c2d93c7fa1 |
| institution | OA Journals |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-79dd9a4a52a548b6bbc293c2d93c7fa12025-08-20T02:07:20ZengWileyInternational Journal of Endocrinology1687-83371687-83452013-01-01201310.1155/2013/704967704967Granulocyte Macrophage Colony Stimulating Factor Supplementation in Culture Media for Subfertile Women Undergoing Assisted Reproduction Technologies: A Systematic ReviewCharalampos Siristatidis0Paraskevi Vogiatzi1George Salamalekis2Maria Creatsa3Nikos Vrachnis4Demián Glujovsky5Zoe Iliodromiti6Charalampos Chrelias7Assisted Reproduction Unit, Third Department of Obstetrics and Gynecology, University of Athens, Rimini 1, Chaidari, 12642 Athens, GreeceAssisted Reproduction Unit, Third Department of Obstetrics and Gynecology, University of Athens, Rimini 1, Chaidari, 12642 Athens, GreeceAssisted Reproduction Unit, Third Department of Obstetrics and Gynecology, University of Athens, Rimini 1, Chaidari, 12642 Athens, GreeceAssisted Reproduction Unit, Third Department of Obstetrics and Gynecology, University of Athens, Rimini 1, Chaidari, 12642 Athens, GreeceSecond Department of Obstetrics and Gynecology, Aretaieion Hospital, University of Athens, Vas Sofias 76, 11528 Athens, GreeceMédico Especialista en Medicina Reproductiva (SAMeR), Especialista Universitario en Ginecología y Obstetricia, Magíster en Efectividad Clínica, Viamonte 1432, Buenos Aires, ArgentinaSecond Department of Obstetrics and Gynecology, Aretaieion Hospital, University of Athens, Vas Sofias 76, 11528 Athens, GreeceThird Department of Obstetrics and Gynecology, University of Athens, Attikon Hospital, Rimini 1, Chaidari, 12642 Athens, GreeceGranulocyte macrophage colony stimulating factor (GM-CSF) is a cytokine/growth factor produced by epithelial cells that exerts embryotrophic effects during the early stages of embryo development. We performed a systematic review, and six studies that were performed in humans undergoing assisted reproduction technologies (ART) were located. We wanted to evaluate if embryo culture media supplementation with GM-CSF could improve success rates. As the type of studies and the outcome parameters investigated were heterogeneous, we decided not to perform a meta-analysis. Most of them had a trend favoring the supplementation with GM-CSF, when outcomes were measured in terms of increased percentage of good-quality embryos reaching the blastocyst stage, improved hatching initiation and number of cells in the blastocyst, and reduction of cell death. However, no statistically significant differences were found in implantation and pregnancy rates in all apart from one large multicenter trial, which reported favorable outcomes, in terms of implantation and live birth rates. We propose properly conducted and adequately powered randomized controlled trials (RCTs) to further validate and extrapolate the current findings with the live birth rate to be the primary outcome measure.http://dx.doi.org/10.1155/2013/704967 |
| spellingShingle | Charalampos Siristatidis Paraskevi Vogiatzi George Salamalekis Maria Creatsa Nikos Vrachnis Demián Glujovsky Zoe Iliodromiti Charalampos Chrelias Granulocyte Macrophage Colony Stimulating Factor Supplementation in Culture Media for Subfertile Women Undergoing Assisted Reproduction Technologies: A Systematic Review International Journal of Endocrinology |
| title | Granulocyte Macrophage Colony Stimulating Factor Supplementation in Culture Media for Subfertile Women Undergoing Assisted Reproduction Technologies: A Systematic Review |
| title_full | Granulocyte Macrophage Colony Stimulating Factor Supplementation in Culture Media for Subfertile Women Undergoing Assisted Reproduction Technologies: A Systematic Review |
| title_fullStr | Granulocyte Macrophage Colony Stimulating Factor Supplementation in Culture Media for Subfertile Women Undergoing Assisted Reproduction Technologies: A Systematic Review |
| title_full_unstemmed | Granulocyte Macrophage Colony Stimulating Factor Supplementation in Culture Media for Subfertile Women Undergoing Assisted Reproduction Technologies: A Systematic Review |
| title_short | Granulocyte Macrophage Colony Stimulating Factor Supplementation in Culture Media for Subfertile Women Undergoing Assisted Reproduction Technologies: A Systematic Review |
| title_sort | granulocyte macrophage colony stimulating factor supplementation in culture media for subfertile women undergoing assisted reproduction technologies a systematic review |
| url | http://dx.doi.org/10.1155/2013/704967 |
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