The evolving landscape of prostate cancer stem cell: Therapeutic implications and future challenges
Prostate cancer (PCa) is the most common cause of malignancy in males and the second leading cause of cancer mortality in United States. Current treatments for PCa include surgery, radiotherapy, and androgen-deprivation therapy. Eventually, PCa relapses to an advanced castration-resistant PCa (CRPC)...
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Elsevier
2016-10-01
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| Series: | Asian Journal of Urology |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214388216300674 |
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| author | Eun-Jin Yun U-Ging Lo Jer-Tsong Hsieh |
| author_facet | Eun-Jin Yun U-Ging Lo Jer-Tsong Hsieh |
| author_sort | Eun-Jin Yun |
| collection | DOAJ |
| description | Prostate cancer (PCa) is the most common cause of malignancy in males and the second leading cause of cancer mortality in United States. Current treatments for PCa include surgery, radiotherapy, and androgen-deprivation therapy. Eventually, PCa relapses to an advanced castration-resistant PCa (CRPC) that becomes a systematic disease and incurable. Therefore, identifying cellular components and molecular mechanisms that drive aggressive PCa at early stage is critical for disease prognosis and therapeutic intervention. One potential strategy for aggressive PCa is to target cancer stem cells (CSCs) that are identified by several unique characteristics such as immortal, self-renewal, and pluripotency. Also, CSC is believed to be a major factor contributing to resistance to radiotherapy and conventional chemotherapies. Moreover, CSCs are thought to be the critical cause of metastasis, tumor recurrence and cancer-related death of multiple cancer types, including PCa. In this review, we discuss recent progress made in understanding prostate cancer stem cells (PCSCs). We focus on the therapeutic strategies aimed at targeting specific surface markers of CSCs, the key signaling pathways in the maintenance of self-renewal capacity of CSCs, ATP-binding cassette (ABC) transporters that mediate the drug-resistance of CSCs, dysregulated microRNAs expression profiles in CSCs, and immunotherapeutic strategies developed against PCSCs surface markers. Keywords: Prostate cancer, Cancer stem cell, Normal stem cell |
| format | Article |
| id | doaj-art-79d9b9c2f3a24b8fb5d58213d92e090b |
| institution | DOAJ |
| issn | 2214-3882 |
| language | English |
| publishDate | 2016-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Asian Journal of Urology |
| spelling | doaj-art-79d9b9c2f3a24b8fb5d58213d92e090b2025-08-20T03:09:55ZengElsevierAsian Journal of Urology2214-38822016-10-013420321010.1016/j.ajur.2016.09.006The evolving landscape of prostate cancer stem cell: Therapeutic implications and future challengesEun-Jin Yun0U-Ging Lo1Jer-Tsong Hsieh2Department of Urology, UT Southwestern Medical Center, Dallas, TX, USADepartment of Urology, UT Southwestern Medical Center, Dallas, TX, USACorresponding author.; Department of Urology, UT Southwestern Medical Center, Dallas, TX, USAProstate cancer (PCa) is the most common cause of malignancy in males and the second leading cause of cancer mortality in United States. Current treatments for PCa include surgery, radiotherapy, and androgen-deprivation therapy. Eventually, PCa relapses to an advanced castration-resistant PCa (CRPC) that becomes a systematic disease and incurable. Therefore, identifying cellular components and molecular mechanisms that drive aggressive PCa at early stage is critical for disease prognosis and therapeutic intervention. One potential strategy for aggressive PCa is to target cancer stem cells (CSCs) that are identified by several unique characteristics such as immortal, self-renewal, and pluripotency. Also, CSC is believed to be a major factor contributing to resistance to radiotherapy and conventional chemotherapies. Moreover, CSCs are thought to be the critical cause of metastasis, tumor recurrence and cancer-related death of multiple cancer types, including PCa. In this review, we discuss recent progress made in understanding prostate cancer stem cells (PCSCs). We focus on the therapeutic strategies aimed at targeting specific surface markers of CSCs, the key signaling pathways in the maintenance of self-renewal capacity of CSCs, ATP-binding cassette (ABC) transporters that mediate the drug-resistance of CSCs, dysregulated microRNAs expression profiles in CSCs, and immunotherapeutic strategies developed against PCSCs surface markers. Keywords: Prostate cancer, Cancer stem cell, Normal stem cellhttp://www.sciencedirect.com/science/article/pii/S2214388216300674 |
| spellingShingle | Eun-Jin Yun U-Ging Lo Jer-Tsong Hsieh The evolving landscape of prostate cancer stem cell: Therapeutic implications and future challenges Asian Journal of Urology |
| title | The evolving landscape of prostate cancer stem cell: Therapeutic implications and future challenges |
| title_full | The evolving landscape of prostate cancer stem cell: Therapeutic implications and future challenges |
| title_fullStr | The evolving landscape of prostate cancer stem cell: Therapeutic implications and future challenges |
| title_full_unstemmed | The evolving landscape of prostate cancer stem cell: Therapeutic implications and future challenges |
| title_short | The evolving landscape of prostate cancer stem cell: Therapeutic implications and future challenges |
| title_sort | evolving landscape of prostate cancer stem cell therapeutic implications and future challenges |
| url | http://www.sciencedirect.com/science/article/pii/S2214388216300674 |
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