Truncated and helix-constrained peptides with high affinity and specificity for the cFos coiled-coil of AP-1.

Truncated and helix-constrained peptides with high affinity and specificity for the cFos coiled-coil of AP-1.

Protein-based therapeutics feature large interacting surfaces. Protein folding endows structural stability to localised surface epitopes, imparting high affinity and target specificity upon interactions with binding partners. However, short synthetic peptides with sequences corresponding to such pro...

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Bibliographic Details
Main Authors: Tara Rao, Gloria Ruiz-Gómez, Timothy A Hill, Huy N Hoang, David P Fairlie, Jody M Mason
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0059415&type=printable
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