Role of exosomes in castration-resistant prostate cancer
Prostate cancer (PCa) is one of the most common urological malignancies in older male patients. Castration-resistant prostate cancer (CRPC) is an aggressive and refractory stage of PCa and is the leading cause of PCa-related deaths. Exosomes are small spherical vesicles with a lipid bilayer membrane...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-05-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1498733/full |
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| author | Yuan Cao Yuan Cao Jianjun Wang Jianjun Wang Huiwen Luo Yaodong Wang Xianfu Cai Xianfu Cai Tiansheng Zhang Yougang Liao Decai Wang Decai Wang |
| author_facet | Yuan Cao Yuan Cao Jianjun Wang Jianjun Wang Huiwen Luo Yaodong Wang Xianfu Cai Xianfu Cai Tiansheng Zhang Yougang Liao Decai Wang Decai Wang |
| author_sort | Yuan Cao |
| collection | DOAJ |
| description | Prostate cancer (PCa) is one of the most common urological malignancies in older male patients. Castration-resistant prostate cancer (CRPC) is an aggressive and refractory stage of PCa and is the leading cause of PCa-related deaths. Exosomes are small spherical vesicles with a lipid bilayer membrane structure, secreted by cells, which carry large amounts of nucleic acids, proteins, lipids, and various important reactive small molecules. Numerous studies have demonstrated that exosomes are involved in the development of CRPC by delivering various biomolecules that regulate biological processes in recipient cells. Despite the advancement in treatments, CRPC remains poorly managed, underscoring the urgent need for novel treatment strategies.As research into exosomes continues, they have shown significant potential in the diagnosis and treatment of CRPC.Unlike previous reviews,this review not only provides an overview of exosomes but also comprehensively explores their role in the CRPC tumor microenvironment, angiogenesis, immune escape, metastasis, and drug resistance, with a focus on the potential value of exosomes in the diagnosis and treatment of CRPC.The literature review includes studies published up to June 2024, and the search strategy involved exosomes, CRPC, diagnosis,and treatment using Pubmed. |
| format | Article |
| id | doaj-art-79d75723c219438ba6e696bb5b2d43a5 |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-79d75723c219438ba6e696bb5b2d43a52025-08-20T03:49:22ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-05-011510.3389/fonc.2025.14987331498733Role of exosomes in castration-resistant prostate cancerYuan Cao0Yuan Cao1Jianjun Wang2Jianjun Wang3Huiwen Luo4Yaodong Wang5Xianfu Cai6Xianfu Cai7Tiansheng Zhang8Yougang Liao9Decai Wang10Decai Wang11Department of Urology, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, ChinaNational Health Commission (NHC) Key Laboratory of Nuclear Technology Medical Transformation, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, ChinaNational Health Commission (NHC) Key Laboratory of Nuclear Technology Medical Transformation, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, ChinaDepartment of Hepatobiliary Surgery, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, ChinaNational Health Commission (NHC) Key Laboratory of Nuclear Technology Medical Transformation, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, ChinaDepartment of Urology, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, ChinaDepartment of Urology, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, ChinaNational Health Commission (NHC) Key Laboratory of Nuclear Technology Medical Transformation, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, ChinaDepartment of Urology, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, ChinaDepartment of Urology, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, ChinaDepartment of Urology, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, ChinaNational Health Commission (NHC) Key Laboratory of Nuclear Technology Medical Transformation, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, ChinaProstate cancer (PCa) is one of the most common urological malignancies in older male patients. Castration-resistant prostate cancer (CRPC) is an aggressive and refractory stage of PCa and is the leading cause of PCa-related deaths. Exosomes are small spherical vesicles with a lipid bilayer membrane structure, secreted by cells, which carry large amounts of nucleic acids, proteins, lipids, and various important reactive small molecules. Numerous studies have demonstrated that exosomes are involved in the development of CRPC by delivering various biomolecules that regulate biological processes in recipient cells. Despite the advancement in treatments, CRPC remains poorly managed, underscoring the urgent need for novel treatment strategies.As research into exosomes continues, they have shown significant potential in the diagnosis and treatment of CRPC.Unlike previous reviews,this review not only provides an overview of exosomes but also comprehensively explores their role in the CRPC tumor microenvironment, angiogenesis, immune escape, metastasis, and drug resistance, with a focus on the potential value of exosomes in the diagnosis and treatment of CRPC.The literature review includes studies published up to June 2024, and the search strategy involved exosomes, CRPC, diagnosis,and treatment using Pubmed.https://www.frontiersin.org/articles/10.3389/fonc.2025.1498733/fullbiomarkerexosomescastration-resistant prostate cancerdiagnosistreatment |
| spellingShingle | Yuan Cao Yuan Cao Jianjun Wang Jianjun Wang Huiwen Luo Yaodong Wang Xianfu Cai Xianfu Cai Tiansheng Zhang Yougang Liao Decai Wang Decai Wang Role of exosomes in castration-resistant prostate cancer Frontiers in Oncology biomarker exosomes castration-resistant prostate cancer diagnosis treatment |
| title | Role of exosomes in castration-resistant prostate cancer |
| title_full | Role of exosomes in castration-resistant prostate cancer |
| title_fullStr | Role of exosomes in castration-resistant prostate cancer |
| title_full_unstemmed | Role of exosomes in castration-resistant prostate cancer |
| title_short | Role of exosomes in castration-resistant prostate cancer |
| title_sort | role of exosomes in castration resistant prostate cancer |
| topic | biomarker exosomes castration-resistant prostate cancer diagnosis treatment |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1498733/full |
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