Scope of mean neutrophil volume as an indicator of neonatal sepsis
Background: Neonatal sepsis is one of the leading causes of mortality in developing countries because of its non-specific presentation. Blood culture is the gold standard for diagnosing sepsis, but culture results take 48 – 72 hours. Therefore, there is a need for an indicator that could be used as...
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Association of Clinical Pathologists of Nepal
2022-09-01
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| Series: | Journal of Pathology of Nepal |
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| Online Access: | https://www.nepjol.info/index.php/JPN/article/view/43997 |
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| author | Chaitra B E Raja Parthiban Shilpa G Indrani Krishnappa Impana Gowda |
| author_facet | Chaitra B E Raja Parthiban Shilpa G Indrani Krishnappa Impana Gowda |
| author_sort | Chaitra B E |
| collection | DOAJ |
| description | Background: Neonatal sepsis is one of the leading causes of mortality in developing countries because of its non-specific presentation. Blood culture is the gold standard for diagnosing sepsis, but culture results take 48 – 72 hours. Therefore, there is a need for an indicator that could be used as a simple parameter to indicate the possibility of evolving sepsis to the clinician. The efficacy of mean neutrophil volume as an indicator must be evaluated.
Materials and methods: The study aims to evaluate the utility of the mean neutrophil volume in the early diagnosis of neonatal sepsis. Following ethical clearance, the study involved analyzing mean neutrophil volume from peripheral smears of 50 newborns clinically diagnosed with neonatal sepsis. The control group included mean neutrophil volume findings from peripheral smears of normal newborns. Maternal or fetal factors like pregnancy-induced hypertension and birth asphyxia that could cause changes in neutrophils were excluded. The mean neutrophil value was calculated after establishing the mean diameter of 100 neutrophils per case using the National Institutes of Health Image J software.
Results: The average mean neutrophil volume was found to be significantly increased in the sepsis group (181x104fl) than in the control group (739x103fl). A statistically significant difference (p= < 0.0001) in the mean neutrophil volume was observed.
Conclusions: Mean neutrophil volume is a potential indicator to distinguish neonates with and without sepsis and help clinicians in the early diagnosis and management of sepsis. |
| format | Article |
| id | doaj-art-79d5b6fe641b473984cbdb94f886e97a |
| institution | Kabale University |
| issn | 2091-0797 2091-0908 |
| language | English |
| publishDate | 2022-09-01 |
| publisher | Association of Clinical Pathologists of Nepal |
| record_format | Article |
| series | Journal of Pathology of Nepal |
| spelling | doaj-art-79d5b6fe641b473984cbdb94f886e97a2025-08-21T07:03:01ZengAssociation of Clinical Pathologists of NepalJournal of Pathology of Nepal2091-07972091-09082022-09-011221931193510.3126/jpn.v12i2.4399771062Scope of mean neutrophil volume as an indicator of neonatal sepsisChaitra B E0Raja Parthiban1Shilpa G2Indrani Krishnappa3https://orcid.org/0000-0002-5208-2621Impana Gowda4MVJ Medical College & Research Hospital, Banglalore, IndiaMVJ Medical College & Research Hospital, Banglalore, IndiaMVJ Medical College & Research Hospital, Banglalore, IndiaMVJ Medical College & Research Hospital, Banglalore, IndiaMVJ Medical College & Research Hospital, Banglalore, IndiaBackground: Neonatal sepsis is one of the leading causes of mortality in developing countries because of its non-specific presentation. Blood culture is the gold standard for diagnosing sepsis, but culture results take 48 – 72 hours. Therefore, there is a need for an indicator that could be used as a simple parameter to indicate the possibility of evolving sepsis to the clinician. The efficacy of mean neutrophil volume as an indicator must be evaluated. Materials and methods: The study aims to evaluate the utility of the mean neutrophil volume in the early diagnosis of neonatal sepsis. Following ethical clearance, the study involved analyzing mean neutrophil volume from peripheral smears of 50 newborns clinically diagnosed with neonatal sepsis. The control group included mean neutrophil volume findings from peripheral smears of normal newborns. Maternal or fetal factors like pregnancy-induced hypertension and birth asphyxia that could cause changes in neutrophils were excluded. The mean neutrophil value was calculated after establishing the mean diameter of 100 neutrophils per case using the National Institutes of Health Image J software. Results: The average mean neutrophil volume was found to be significantly increased in the sepsis group (181x104fl) than in the control group (739x103fl). A statistically significant difference (p= < 0.0001) in the mean neutrophil volume was observed. Conclusions: Mean neutrophil volume is a potential indicator to distinguish neonates with and without sepsis and help clinicians in the early diagnosis and management of sepsis.https://www.nepjol.info/index.php/JPN/article/view/43997inflammation; mean neutrophil volume; neonatal sepsis; sepsis; |
| spellingShingle | Chaitra B E Raja Parthiban Shilpa G Indrani Krishnappa Impana Gowda Scope of mean neutrophil volume as an indicator of neonatal sepsis Journal of Pathology of Nepal inflammation; mean neutrophil volume; neonatal sepsis; sepsis; |
| title | Scope of mean neutrophil volume as an indicator of neonatal sepsis |
| title_full | Scope of mean neutrophil volume as an indicator of neonatal sepsis |
| title_fullStr | Scope of mean neutrophil volume as an indicator of neonatal sepsis |
| title_full_unstemmed | Scope of mean neutrophil volume as an indicator of neonatal sepsis |
| title_short | Scope of mean neutrophil volume as an indicator of neonatal sepsis |
| title_sort | scope of mean neutrophil volume as an indicator of neonatal sepsis |
| topic | inflammation; mean neutrophil volume; neonatal sepsis; sepsis; |
| url | https://www.nepjol.info/index.php/JPN/article/view/43997 |
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