Chlorogenic acid alleviates cadmium-induced neuronal injury in chicken cerebral cortex by inhibiting incomplete autophagy mediated by AMPK-ULK1 pathway
Cadmium (Cd) is an environmental pollutant that has neurotoxic properties, which poses serious threats to human health and the development of poultry farming. Chlorogenic acid (CGA) is a dietary polyphenol exhibit various biological activities such as antioxidant, anti-inflammatory, and autophagy re...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Poultry Science |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0032579124011751 |
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| author | Li Wang Chaofan Zhang Muhammad Azhar Memon Qianting Shi Le Lu Xishuai Tong Yonggang Ma Hui Zou Jianhong Gu Xuezhong Liu Jianchun Bian Zongping Liu Yan Yuan |
| author_facet | Li Wang Chaofan Zhang Muhammad Azhar Memon Qianting Shi Le Lu Xishuai Tong Yonggang Ma Hui Zou Jianhong Gu Xuezhong Liu Jianchun Bian Zongping Liu Yan Yuan |
| author_sort | Li Wang |
| collection | DOAJ |
| description | Cadmium (Cd) is an environmental pollutant that has neurotoxic properties, which poses serious threats to human health and the development of poultry farming. Chlorogenic acid (CGA) is a dietary polyphenol exhibit various biological activities such as antioxidant, anti-inflammatory, and autophagy regulation. In addition, CGA can penetrate the blood-brain barrier and exert neuroprotective effects. This study explored the mechanism of CGA in alleviating Cd-induced cerebral cortical neuron injury in chickens. The results showed that in vivo, CGA reduced the Cd level and alleviated Cd-induced histopathological and ultrastructural damages in the chicken cerebral cortex. Further research has found that CGA alleviated Cd-induced incomplete autophagy and activation of the AMPK-ULK1 pathway. In vitro, AMPK inhibitors (Compound C) could alleviate Cd-induced incomplete autophagy in chicken cerebral cortical neurons. In addition, CGA alleviated the decreased viability, incomplete autophagy, and activation of the AMPK-ULK1 pathway induced by Cd in chicken cerebral cortical neurons. In summary, CGA can alleviate Cd-induced cerebral cortical neuron injury in chickens, which is related to CGA alleviating Cd-induced incomplete autophagy by inhibiting the AMPK-ULK1 pathway. |
| format | Article |
| id | doaj-art-79d44457d68c47d6b493968557a28a17 |
| institution | Kabale University |
| issn | 0032-5791 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Poultry Science |
| spelling | doaj-art-79d44457d68c47d6b493968557a28a172025-01-22T05:40:38ZengElsevierPoultry Science0032-57912025-01-011041104597Chlorogenic acid alleviates cadmium-induced neuronal injury in chicken cerebral cortex by inhibiting incomplete autophagy mediated by AMPK-ULK1 pathwayLi Wang0Chaofan Zhang1Muhammad Azhar Memon2Qianting Shi3Le Lu4Xishuai Tong5Yonggang Ma6Hui Zou7Jianhong Gu8Xuezhong Liu9Jianchun Bian10Zongping Liu11Yan Yuan12College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, Jiangsu, China.; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, 225009, PR China.College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, Jiangsu, China.; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, 225009, PR China.MOE Joint International Research, Nanjing Agricultural University 210095, China.College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, Jiangsu, China.; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, 225009, PR China.College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, Jiangsu, China.; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, 225009, PR China.College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, Jiangsu, China.; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, 225009, PR China.College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, Jiangsu, China.; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, 225009, PR China.College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, Jiangsu, China.; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, 225009, PR China.College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, Jiangsu, China.; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, 225009, PR China.College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, Jiangsu, China.; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, 225009, PR China.College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, Jiangsu, China.; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, 225009, PR China.College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, Jiangsu, China.; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, 225009, PR China.College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, Jiangsu, China.; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, 225009, PR China.; Corresponding author at: College of Veterinary Medicine, Yangzhou University, 12 East Wenhui Road, Yangzhou 225009, China.Cadmium (Cd) is an environmental pollutant that has neurotoxic properties, which poses serious threats to human health and the development of poultry farming. Chlorogenic acid (CGA) is a dietary polyphenol exhibit various biological activities such as antioxidant, anti-inflammatory, and autophagy regulation. In addition, CGA can penetrate the blood-brain barrier and exert neuroprotective effects. This study explored the mechanism of CGA in alleviating Cd-induced cerebral cortical neuron injury in chickens. The results showed that in vivo, CGA reduced the Cd level and alleviated Cd-induced histopathological and ultrastructural damages in the chicken cerebral cortex. Further research has found that CGA alleviated Cd-induced incomplete autophagy and activation of the AMPK-ULK1 pathway. In vitro, AMPK inhibitors (Compound C) could alleviate Cd-induced incomplete autophagy in chicken cerebral cortical neurons. In addition, CGA alleviated the decreased viability, incomplete autophagy, and activation of the AMPK-ULK1 pathway induced by Cd in chicken cerebral cortical neurons. In summary, CGA can alleviate Cd-induced cerebral cortical neuron injury in chickens, which is related to CGA alleviating Cd-induced incomplete autophagy by inhibiting the AMPK-ULK1 pathway.http://www.sciencedirect.com/science/article/pii/S0032579124011751CadmiumChlorogenic acidChicken cerebral cortical neuronsAMPK-ULK1 pathway |
| spellingShingle | Li Wang Chaofan Zhang Muhammad Azhar Memon Qianting Shi Le Lu Xishuai Tong Yonggang Ma Hui Zou Jianhong Gu Xuezhong Liu Jianchun Bian Zongping Liu Yan Yuan Chlorogenic acid alleviates cadmium-induced neuronal injury in chicken cerebral cortex by inhibiting incomplete autophagy mediated by AMPK-ULK1 pathway Poultry Science Cadmium Chlorogenic acid Chicken cerebral cortical neurons AMPK-ULK1 pathway |
| title | Chlorogenic acid alleviates cadmium-induced neuronal injury in chicken cerebral cortex by inhibiting incomplete autophagy mediated by AMPK-ULK1 pathway |
| title_full | Chlorogenic acid alleviates cadmium-induced neuronal injury in chicken cerebral cortex by inhibiting incomplete autophagy mediated by AMPK-ULK1 pathway |
| title_fullStr | Chlorogenic acid alleviates cadmium-induced neuronal injury in chicken cerebral cortex by inhibiting incomplete autophagy mediated by AMPK-ULK1 pathway |
| title_full_unstemmed | Chlorogenic acid alleviates cadmium-induced neuronal injury in chicken cerebral cortex by inhibiting incomplete autophagy mediated by AMPK-ULK1 pathway |
| title_short | Chlorogenic acid alleviates cadmium-induced neuronal injury in chicken cerebral cortex by inhibiting incomplete autophagy mediated by AMPK-ULK1 pathway |
| title_sort | chlorogenic acid alleviates cadmium induced neuronal injury in chicken cerebral cortex by inhibiting incomplete autophagy mediated by ampk ulk1 pathway |
| topic | Cadmium Chlorogenic acid Chicken cerebral cortical neurons AMPK-ULK1 pathway |
| url | http://www.sciencedirect.com/science/article/pii/S0032579124011751 |
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