Effect of myo-inositol on the prevention of gestational diabetes in high-risk pregnant women: An RCT
Background: Gestational diabetes mellitus (GDM) is a rising problem which, if not diagnosed and treated in time, can lead to maternal, fetal, and neonatal complications. Therefore, it is very important to consider predisposing factors and prevention of GDM. Objective: This study aims to investig...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Shahid Sadoughi University of Medical Sciences
2025-05-01
|
| Series: | International Journal of Reproductive BioMedicine |
| Subjects: | |
| Online Access: | https://knepublishing.com/index.php/ijrm/article/view/18784 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849422263788503040 |
|---|---|
| author | Ashraf Moini Mahboobeh Shirazi Mahdi Sepidarkish Maryam Rabiei Afsaneh Tehranian Arshia Shizarpour Reihaneh Pirjani |
| author_facet | Ashraf Moini Mahboobeh Shirazi Mahdi Sepidarkish Maryam Rabiei Afsaneh Tehranian Arshia Shizarpour Reihaneh Pirjani |
| author_sort | Ashraf Moini |
| collection | DOAJ |
| description |
Background: Gestational diabetes mellitus (GDM) is a rising problem which, if not diagnosed and treated in time, can lead to maternal, fetal, and neonatal complications. Therefore, it is very important to consider predisposing factors and prevention of GDM.
Objective: This study aims to investigate the effect of myo-inositol (MI) on the prevention of GDM and other pregnancy outcomes.
Materials and Methods: This randomized controlled trial was conducted at the Arash Women’s hospital and Yas hospital Complex, Tehran, Iran between November 2019 and May 2020 and included 150 women; the study was divided into 2 groups (n = 75/each). Women received 4000 mg of MI plus 400 mg of folic acid daily in the MI group and 400 mg of folic acid in the placebo group from 11–14 gestational weeks for 14 wk. Participants underwent 75 gr oral glucose tolerance test at 24–28 wk and were followed up until delivery.
Results: After adjustment for confounding factors, MI treatment was associated with a significant reduction of GDM (aRR: 0.58, 0.36, 0.91, p = 0.020). However, no significant difference was observed between the 2 groups in cases of other pregnancy outcomes and glycemia at each step of oral glucose tolerance test values.
Conclusion: Our results showed that MI significantly reduced GDM. With insufficient evidences, more studies with an appropriate sample size are recommended.
|
| format | Article |
| id | doaj-art-79cf191bce6041cebc856f50a344cd88 |
| institution | Kabale University |
| issn | 2476-4108 2476-3772 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Shahid Sadoughi University of Medical Sciences |
| record_format | Article |
| series | International Journal of Reproductive BioMedicine |
| spelling | doaj-art-79cf191bce6041cebc856f50a344cd882025-08-20T03:31:10ZengShahid Sadoughi University of Medical SciencesInternational Journal of Reproductive BioMedicine2476-41082476-37722025-05-0123410.18502/ijrm.v23i4.18784Effect of myo-inositol on the prevention of gestational diabetes in high-risk pregnant women: An RCTAshraf Moini0Mahboobeh Shirazi1Mahdi Sepidarkish2Maryam Rabiei3Afsaneh Tehranian4Arshia Shizarpour5Reihaneh Pirjani6Obstetrics and Gynecology Department, Arash Women’s Hospital, Tehran University of Medical Sciences, TehranObstetrics and Gynecology Department, Yas Complex Hospital, Tehran University of Medical Sciences, TehranCellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, BabolObstetrics and Gynecology Department, Arash Women’s Hospital, Tehran University of Medical Sciences, TehranObstetrics and Gynecology Department, Research Development Center, Arash Women’s Hospital, Tehran University of Medical Sciences, TehranStudents’ Scientific Research Center, Tehran University of Medical Sciences, TehranObstetrics and Gynecology Department, Arash Women’s Hospital, Tehran University of Medical Sciences, Tehran Background: Gestational diabetes mellitus (GDM) is a rising problem which, if not diagnosed and treated in time, can lead to maternal, fetal, and neonatal complications. Therefore, it is very important to consider predisposing factors and prevention of GDM. Objective: This study aims to investigate the effect of myo-inositol (MI) on the prevention of GDM and other pregnancy outcomes. Materials and Methods: This randomized controlled trial was conducted at the Arash Women’s hospital and Yas hospital Complex, Tehran, Iran between November 2019 and May 2020 and included 150 women; the study was divided into 2 groups (n = 75/each). Women received 4000 mg of MI plus 400 mg of folic acid daily in the MI group and 400 mg of folic acid in the placebo group from 11–14 gestational weeks for 14 wk. Participants underwent 75 gr oral glucose tolerance test at 24–28 wk and were followed up until delivery. Results: After adjustment for confounding factors, MI treatment was associated with a significant reduction of GDM (aRR: 0.58, 0.36, 0.91, p = 0.020). However, no significant difference was observed between the 2 groups in cases of other pregnancy outcomes and glycemia at each step of oral glucose tolerance test values. Conclusion: Our results showed that MI significantly reduced GDM. With insufficient evidences, more studies with an appropriate sample size are recommended. https://knepublishing.com/index.php/ijrm/article/view/18784Gestational diabetes mellitusPregnancyMyo-inositolPrimary prevention |
| spellingShingle | Ashraf Moini Mahboobeh Shirazi Mahdi Sepidarkish Maryam Rabiei Afsaneh Tehranian Arshia Shizarpour Reihaneh Pirjani Effect of myo-inositol on the prevention of gestational diabetes in high-risk pregnant women: An RCT International Journal of Reproductive BioMedicine Gestational diabetes mellitus Pregnancy Myo-inositol Primary prevention |
| title | Effect of myo-inositol on the prevention of gestational diabetes in high-risk pregnant women: An RCT |
| title_full | Effect of myo-inositol on the prevention of gestational diabetes in high-risk pregnant women: An RCT |
| title_fullStr | Effect of myo-inositol on the prevention of gestational diabetes in high-risk pregnant women: An RCT |
| title_full_unstemmed | Effect of myo-inositol on the prevention of gestational diabetes in high-risk pregnant women: An RCT |
| title_short | Effect of myo-inositol on the prevention of gestational diabetes in high-risk pregnant women: An RCT |
| title_sort | effect of myo inositol on the prevention of gestational diabetes in high risk pregnant women an rct |
| topic | Gestational diabetes mellitus Pregnancy Myo-inositol Primary prevention |
| url | https://knepublishing.com/index.php/ijrm/article/view/18784 |
| work_keys_str_mv | AT ashrafmoini effectofmyoinositolonthepreventionofgestationaldiabetesinhighriskpregnantwomenanrct AT mahboobehshirazi effectofmyoinositolonthepreventionofgestationaldiabetesinhighriskpregnantwomenanrct AT mahdisepidarkish effectofmyoinositolonthepreventionofgestationaldiabetesinhighriskpregnantwomenanrct AT maryamrabiei effectofmyoinositolonthepreventionofgestationaldiabetesinhighriskpregnantwomenanrct AT afsanehtehranian effectofmyoinositolonthepreventionofgestationaldiabetesinhighriskpregnantwomenanrct AT arshiashizarpour effectofmyoinositolonthepreventionofgestationaldiabetesinhighriskpregnantwomenanrct AT reihanehpirjani effectofmyoinositolonthepreventionofgestationaldiabetesinhighriskpregnantwomenanrct |