Synergistic Effects of Human Platelet-Rich Plasma Combined with Adipose-Derived Stem Cells on Healing in a Mouse Pressure Injury Model
Pressure injury (PI) affects quality of life and results in economic and social burdens. Local transplantation of human adipose-derived stem cells (ASCs) is considered an effective treatment. However, ASC suspension alone is vulnerable to the immune system and results in a shortened cell survival. T...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2019/3091619 |
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| author | Zhiyuan Liu Shune Xiao Kerong Tao Hai Li Wenhu Jin Zairong Wei Dali Wang Chengliang Deng |
| author_facet | Zhiyuan Liu Shune Xiao Kerong Tao Hai Li Wenhu Jin Zairong Wei Dali Wang Chengliang Deng |
| author_sort | Zhiyuan Liu |
| collection | DOAJ |
| description | Pressure injury (PI) affects quality of life and results in economic and social burdens. Local transplantation of human adipose-derived stem cells (ASCs) is considered an effective treatment. However, ASC suspension alone is vulnerable to the immune system and results in a shortened cell survival. There is increasing evidence of a synergistic effect of platelet-rich plasma (PRP) combined with ASCs on wound healing. This study investigated the effectiveness, synergy, and mechanism of wound healing following local injection of PRP combined with ASCs in a rodent PI model. PRP or ASCs alone were the control intervention. Wound healing, inflammatory infiltration, collagen deposition, angiogenesis, neurogenesis, and cell homing were investigated. PI healing was promoted by the synergistic effects of PRP combined with ASCs. The combination was more effective than ASCs alone for modulating inflammation, increasing collagen deposition, angiogenesis, neurogenesis, and the persistence of the injected ASCs. These data provide a theoretical foundation for the clinical administration of ASCs combined with PRP in PI healing and skin regeneration. |
| format | Article |
| id | doaj-art-79cc0c4063c64ef999087f82f86eff4c |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-79cc0c4063c64ef999087f82f86eff4c2025-08-20T03:35:47ZengWileyStem Cells International1687-966X1687-96782019-01-01201910.1155/2019/30916193091619Synergistic Effects of Human Platelet-Rich Plasma Combined with Adipose-Derived Stem Cells on Healing in a Mouse Pressure Injury ModelZhiyuan Liu0Shune Xiao1Kerong Tao2Hai Li3Wenhu Jin4Zairong Wei5Dali Wang6Chengliang Deng7Department of Plastic Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, ChinaDepartment of Plastic Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, ChinaDepartment of Plastic Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, ChinaDepartment of Plastic Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, ChinaDepartment of Plastic Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, ChinaDepartment of Plastic Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, ChinaDepartment of Plastic Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, ChinaDepartment of Plastic Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, ChinaPressure injury (PI) affects quality of life and results in economic and social burdens. Local transplantation of human adipose-derived stem cells (ASCs) is considered an effective treatment. However, ASC suspension alone is vulnerable to the immune system and results in a shortened cell survival. There is increasing evidence of a synergistic effect of platelet-rich plasma (PRP) combined with ASCs on wound healing. This study investigated the effectiveness, synergy, and mechanism of wound healing following local injection of PRP combined with ASCs in a rodent PI model. PRP or ASCs alone were the control intervention. Wound healing, inflammatory infiltration, collagen deposition, angiogenesis, neurogenesis, and cell homing were investigated. PI healing was promoted by the synergistic effects of PRP combined with ASCs. The combination was more effective than ASCs alone for modulating inflammation, increasing collagen deposition, angiogenesis, neurogenesis, and the persistence of the injected ASCs. These data provide a theoretical foundation for the clinical administration of ASCs combined with PRP in PI healing and skin regeneration.http://dx.doi.org/10.1155/2019/3091619 |
| spellingShingle | Zhiyuan Liu Shune Xiao Kerong Tao Hai Li Wenhu Jin Zairong Wei Dali Wang Chengliang Deng Synergistic Effects of Human Platelet-Rich Plasma Combined with Adipose-Derived Stem Cells on Healing in a Mouse Pressure Injury Model Stem Cells International |
| title | Synergistic Effects of Human Platelet-Rich Plasma Combined with Adipose-Derived Stem Cells on Healing in a Mouse Pressure Injury Model |
| title_full | Synergistic Effects of Human Platelet-Rich Plasma Combined with Adipose-Derived Stem Cells on Healing in a Mouse Pressure Injury Model |
| title_fullStr | Synergistic Effects of Human Platelet-Rich Plasma Combined with Adipose-Derived Stem Cells on Healing in a Mouse Pressure Injury Model |
| title_full_unstemmed | Synergistic Effects of Human Platelet-Rich Plasma Combined with Adipose-Derived Stem Cells on Healing in a Mouse Pressure Injury Model |
| title_short | Synergistic Effects of Human Platelet-Rich Plasma Combined with Adipose-Derived Stem Cells on Healing in a Mouse Pressure Injury Model |
| title_sort | synergistic effects of human platelet rich plasma combined with adipose derived stem cells on healing in a mouse pressure injury model |
| url | http://dx.doi.org/10.1155/2019/3091619 |
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