Precision Imaging in Cervical Cancer: A Comprehensive Approach to Diagnosis and Pre-treatment Evaluation
Objectives: Until 2018, cervical cancer (CC) was clinically staged; however, it was frequently under-staged. For this reason, in 2018, the International Federation of Gynecology and Obstetrics (FIGO) incorporated the imaging assessment into the staging of this malignancy. The aim of this review is t...
Saved in:
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
IMR Press
2024-06-01
|
| Series: | Clinical and Experimental Obstetrics & Gynecology |
| Subjects: | |
| Online Access: | https://www.imrpress.com/journal/CEOG/51/6/10.31083/j.ceog5106145 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850252228637491200 |
|---|---|
| author | Ilaria Cuccu Tullio Golia D’Augè Noemi Tonti Emanuele De Angelis Roberta Arseni Giorgio Bogani Ottavia D’Oria Angela Musella Giorgia Perniola Ludovico Muzii Violante Di Donato Andrea Giannini |
| author_facet | Ilaria Cuccu Tullio Golia D’Augè Noemi Tonti Emanuele De Angelis Roberta Arseni Giorgio Bogani Ottavia D’Oria Angela Musella Giorgia Perniola Ludovico Muzii Violante Di Donato Andrea Giannini |
| author_sort | Ilaria Cuccu |
| collection | DOAJ |
| description | Objectives: Until 2018, cervical cancer (CC) was clinically staged; however, it was frequently under-staged. For this reason, in 2018, the International Federation of Gynecology and Obstetrics (FIGO) incorporated the imaging assessment into the staging of this malignancy. The aim of this review is to discuss available data regarding the role of imaging in the diagnosis, pretreatment staging, and how an adequate radiological evaluation could assist in the treatment planning for CC. Mechanism: An extensive literature search was conducted to identify relevant studies across various databases, including articles addressing topics related to imaging used in CC. The selected articles underwent thorough examination and evaluation to identify studies that met the objectives of this review, taking into account the specified inclusion and exclusion criteria. Subsequently, relevant data were extracted and analyzed for each article. Findings in Brief: Transvaginal ultrasound (TVS) and transrectal ultrasound (TRUS) have been shown to be accurate diagnostic tools to assessing the local spread of CC disease. Currently, magnetic resonance imaging (MRI) appears to offer the highest sensitivity, specificity, and accuracy in detecting parametrial and stromal invasion, as well as tumor size. Computed tomography (CT) and contrast-enhanced (CE)-CT are considered the best imaging modalities for the detection of lymph node metastases. However, positron emission tomography (PET) has demonstrated notable precision and exhibited high negative predictive value in predicting the pelvic nodal status during the early-stage diagnosis of CC diagnosis. Radiomics represents a newly introduced field of translational research with the potential to predict several clinically and pathological relevant variables in cervical carcinoma patients. These variables include disease staging, histological type, lymph node status, probability of recurrence, and estimated survival. Conclusions: Imaging plays an indispensable role in diagnosis, tumor staging, and monitoring the evolution of pathology in response to therapies over time. It provides physicians with the indispensable tool for optimal regulation of therapeutic strategy. |
| format | Article |
| id | doaj-art-79c8d8ff64df47f5b576ba513d135bce |
| institution | OA Journals |
| issn | 0390-6663 |
| language | English |
| publishDate | 2024-06-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Clinical and Experimental Obstetrics & Gynecology |
| spelling | doaj-art-79c8d8ff64df47f5b576ba513d135bce2025-08-20T01:57:43ZengIMR PressClinical and Experimental Obstetrics & Gynecology0390-66632024-06-0151614510.31083/j.ceog5106145S0390-6663(24)02346-7Precision Imaging in Cervical Cancer: A Comprehensive Approach to Diagnosis and Pre-treatment EvaluationIlaria Cuccu0Tullio Golia D’Augè1Noemi Tonti2Emanuele De Angelis3Roberta Arseni4Giorgio Bogani5Ottavia D’Oria6Angela Musella7Giorgia Perniola8Ludovico Muzii9Violante Di Donato10Andrea Giannini11Department of Maternal and Child Health and Urological Sciences, Sapienza University of Rome, Policlinico Umberto I, 00161 Rome, ItalyDepartment of Maternal and Child Health and Urological Sciences, Sapienza University of Rome, Policlinico Umberto I, 00161 Rome, ItalyDepartment of Maternal and Child Health and Urological Sciences, Sapienza University of Rome, Policlinico Umberto I, 00161 Rome, ItalyDepartment of Maternal and Child Health and Urological Sciences, Sapienza University of Rome, Policlinico Umberto I, 00161 Rome, ItalyDepartment of Maternal and Child Health and Urological Sciences, Sapienza University of Rome, Policlinico Umberto I, 00161 Rome, ItalyDepartment of Gynecologic Oncology, IRCCS National Cancer Institute, 20133 Milan, ItalyObstetrics and Gynecological Unit, Department of Woman's and Child's Health, San Camillo-Forlanini Hospital, 00152 Rome, ItalyDepartment of Maternal and Child Health and Urological Sciences, Sapienza University of Rome, Policlinico Umberto I, 00161 Rome, ItalyDepartment of Maternal and Child Health and Urological Sciences, Sapienza University of Rome, Policlinico Umberto I, 00161 Rome, ItalyDepartment of Maternal and Child Health and Urological Sciences, Sapienza University of Rome, Policlinico Umberto I, 00161 Rome, ItalyDepartment of Maternal and Child Health and Urological Sciences, Sapienza University of Rome, Policlinico Umberto I, 00161 Rome, ItalyUnit of Gynecology, Department of Surgical and Medical Sciences and Translational Medicine, Sant'Andrea Hospital, Sapienza University of Rome, 00189 Rome, ItalyObjectives: Until 2018, cervical cancer (CC) was clinically staged; however, it was frequently under-staged. For this reason, in 2018, the International Federation of Gynecology and Obstetrics (FIGO) incorporated the imaging assessment into the staging of this malignancy. The aim of this review is to discuss available data regarding the role of imaging in the diagnosis, pretreatment staging, and how an adequate radiological evaluation could assist in the treatment planning for CC. Mechanism: An extensive literature search was conducted to identify relevant studies across various databases, including articles addressing topics related to imaging used in CC. The selected articles underwent thorough examination and evaluation to identify studies that met the objectives of this review, taking into account the specified inclusion and exclusion criteria. Subsequently, relevant data were extracted and analyzed for each article. Findings in Brief: Transvaginal ultrasound (TVS) and transrectal ultrasound (TRUS) have been shown to be accurate diagnostic tools to assessing the local spread of CC disease. Currently, magnetic resonance imaging (MRI) appears to offer the highest sensitivity, specificity, and accuracy in detecting parametrial and stromal invasion, as well as tumor size. Computed tomography (CT) and contrast-enhanced (CE)-CT are considered the best imaging modalities for the detection of lymph node metastases. However, positron emission tomography (PET) has demonstrated notable precision and exhibited high negative predictive value in predicting the pelvic nodal status during the early-stage diagnosis of CC diagnosis. Radiomics represents a newly introduced field of translational research with the potential to predict several clinically and pathological relevant variables in cervical carcinoma patients. These variables include disease staging, histological type, lymph node status, probability of recurrence, and estimated survival. Conclusions: Imaging plays an indispensable role in diagnosis, tumor staging, and monitoring the evolution of pathology in response to therapies over time. It provides physicians with the indispensable tool for optimal regulation of therapeutic strategy.https://www.imrpress.com/journal/CEOG/51/6/10.31083/j.ceog5106145cervical cancerstaging ultrasoundmripet-ctradiomicsgynecological oncology |
| spellingShingle | Ilaria Cuccu Tullio Golia D’Augè Noemi Tonti Emanuele De Angelis Roberta Arseni Giorgio Bogani Ottavia D’Oria Angela Musella Giorgia Perniola Ludovico Muzii Violante Di Donato Andrea Giannini Precision Imaging in Cervical Cancer: A Comprehensive Approach to Diagnosis and Pre-treatment Evaluation Clinical and Experimental Obstetrics & Gynecology cervical cancer staging ultrasound mri pet-ct radiomics gynecological oncology |
| title | Precision Imaging in Cervical Cancer: A Comprehensive Approach to Diagnosis and Pre-treatment Evaluation |
| title_full | Precision Imaging in Cervical Cancer: A Comprehensive Approach to Diagnosis and Pre-treatment Evaluation |
| title_fullStr | Precision Imaging in Cervical Cancer: A Comprehensive Approach to Diagnosis and Pre-treatment Evaluation |
| title_full_unstemmed | Precision Imaging in Cervical Cancer: A Comprehensive Approach to Diagnosis and Pre-treatment Evaluation |
| title_short | Precision Imaging in Cervical Cancer: A Comprehensive Approach to Diagnosis and Pre-treatment Evaluation |
| title_sort | precision imaging in cervical cancer a comprehensive approach to diagnosis and pre treatment evaluation |
| topic | cervical cancer staging ultrasound mri pet-ct radiomics gynecological oncology |
| url | https://www.imrpress.com/journal/CEOG/51/6/10.31083/j.ceog5106145 |
| work_keys_str_mv | AT ilariacuccu precisionimagingincervicalcanceracomprehensiveapproachtodiagnosisandpretreatmentevaluation AT tulliogoliadauge precisionimagingincervicalcanceracomprehensiveapproachtodiagnosisandpretreatmentevaluation AT noemitonti precisionimagingincervicalcanceracomprehensiveapproachtodiagnosisandpretreatmentevaluation AT emanueledeangelis precisionimagingincervicalcanceracomprehensiveapproachtodiagnosisandpretreatmentevaluation AT robertaarseni precisionimagingincervicalcanceracomprehensiveapproachtodiagnosisandpretreatmentevaluation AT giorgiobogani precisionimagingincervicalcanceracomprehensiveapproachtodiagnosisandpretreatmentevaluation AT ottaviadoria precisionimagingincervicalcanceracomprehensiveapproachtodiagnosisandpretreatmentevaluation AT angelamusella precisionimagingincervicalcanceracomprehensiveapproachtodiagnosisandpretreatmentevaluation AT giorgiaperniola precisionimagingincervicalcanceracomprehensiveapproachtodiagnosisandpretreatmentevaluation AT ludovicomuzii precisionimagingincervicalcanceracomprehensiveapproachtodiagnosisandpretreatmentevaluation AT violantedidonato precisionimagingincervicalcanceracomprehensiveapproachtodiagnosisandpretreatmentevaluation AT andreagiannini precisionimagingincervicalcanceracomprehensiveapproachtodiagnosisandpretreatmentevaluation |