Recent advances in amidyl radical-mediated photocatalytic direct intermolecular hydrogen atom transfer

In recent years, amidyl radicals have emerged as highly efficient and versatile reagents for hydrogen atom transfer (HAT) in photocatalytic reactions. These radicals display exceptional selectivity and efficiency in abstracting hydrogen atoms from C–H, Si–H, B–H, and Ge–H, positioning them as invalu...

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Main Authors: Hao-Sen Wang, Lin Li, Xin Chen, Jian-Li Wu, Kai Sun, Xiao-Lan Chen, Ling-Bo Qu, Bing Yu
Format: Article
Language:English
Published: Beilstein-Institut 2025-06-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
Online Access:https://doi.org/10.3762/bjoc.21.100
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author Hao-Sen Wang
Lin Li
Xin Chen
Jian-Li Wu
Kai Sun
Xiao-Lan Chen
Ling-Bo Qu
Bing Yu
author_facet Hao-Sen Wang
Lin Li
Xin Chen
Jian-Li Wu
Kai Sun
Xiao-Lan Chen
Ling-Bo Qu
Bing Yu
author_sort Hao-Sen Wang
collection DOAJ
description In recent years, amidyl radicals have emerged as highly efficient and versatile reagents for hydrogen atom transfer (HAT) in photocatalytic reactions. These radicals display exceptional selectivity and efficiency in abstracting hydrogen atoms from C–H, Si–H, B–H, and Ge–H, positioning them as invaluable tools in synthetic chemistry. This review summarizes the latest advancements in the photocatalyzed generation of amidyl radicals as HAT reagents, with a particular emphasis on their role in the intermolecular HAT process. We highlight key developments, mechanistic insights, and emerging strategies that harness the unique reactivity of amidyl radicals in the selective functionalization of a variety of substrates.
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institution Kabale University
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publishDate 2025-06-01
publisher Beilstein-Institut
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series Beilstein Journal of Organic Chemistry
spelling doaj-art-79c8687bbcd3498fb4ceb822b7ccc2982025-08-20T03:51:24ZengBeilstein-InstitutBeilstein Journal of Organic Chemistry1860-53972025-06-012111306132310.3762/bjoc.21.1001860-5397-21-100Recent advances in amidyl radical-mediated photocatalytic direct intermolecular hydrogen atom transferHao-Sen Wang0Lin Li1Xin Chen2Jian-Li Wu3Kai Sun4Xiao-Lan Chen5Ling-Bo Qu6Bing Yu7Medical School, Huanghe Science and Technology College, Zhengzhou, 450006, PR China College of Chemistry, Zhengzhou University, Zhengzhou 450001, PR China Institute of Chemistry, Henan Academy of Sciences, Zhengzhou 450002, PR China Medical School, Huanghe Science and Technology College, Zhengzhou, 450006, PR China College of Chemistry, Zhengzhou University, Zhengzhou 450001, PR China College of Chemistry, Zhengzhou University, Zhengzhou 450001, PR China Medical School, Huanghe Science and Technology College, Zhengzhou, 450006, PR China Medical School, Huanghe Science and Technology College, Zhengzhou, 450006, PR China In recent years, amidyl radicals have emerged as highly efficient and versatile reagents for hydrogen atom transfer (HAT) in photocatalytic reactions. These radicals display exceptional selectivity and efficiency in abstracting hydrogen atoms from C–H, Si–H, B–H, and Ge–H, positioning them as invaluable tools in synthetic chemistry. This review summarizes the latest advancements in the photocatalyzed generation of amidyl radicals as HAT reagents, with a particular emphasis on their role in the intermolecular HAT process. We highlight key developments, mechanistic insights, and emerging strategies that harness the unique reactivity of amidyl radicals in the selective functionalization of a variety of substrates.https://doi.org/10.3762/bjoc.21.100amidyl radicalsc–hhat reagentshydrogen-atom-transferlate-stage functionalization
spellingShingle Hao-Sen Wang
Lin Li
Xin Chen
Jian-Li Wu
Kai Sun
Xiao-Lan Chen
Ling-Bo Qu
Bing Yu
Recent advances in amidyl radical-mediated photocatalytic direct intermolecular hydrogen atom transfer
Beilstein Journal of Organic Chemistry
amidyl radicals
c–h
hat reagents
hydrogen-atom-transfer
late-stage functionalization
title Recent advances in amidyl radical-mediated photocatalytic direct intermolecular hydrogen atom transfer
title_full Recent advances in amidyl radical-mediated photocatalytic direct intermolecular hydrogen atom transfer
title_fullStr Recent advances in amidyl radical-mediated photocatalytic direct intermolecular hydrogen atom transfer
title_full_unstemmed Recent advances in amidyl radical-mediated photocatalytic direct intermolecular hydrogen atom transfer
title_short Recent advances in amidyl radical-mediated photocatalytic direct intermolecular hydrogen atom transfer
title_sort recent advances in amidyl radical mediated photocatalytic direct intermolecular hydrogen atom transfer
topic amidyl radicals
c–h
hat reagents
hydrogen-atom-transfer
late-stage functionalization
url https://doi.org/10.3762/bjoc.21.100
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