Oral administration of Momordica charantia-derived extracellular vesicles alleviates ulcerative colitis through comprehensive renovation of the intestinal microenvironment

Oral administration of Momordica charantia-derived extracellular vesicles alleviates ulcerative colitis through comprehensive renovation of the intestinal microenvironment

Abstract Background Ulcerative colitis (UC) is an inflammatory bowel disease (IBD), accompanied by intense inflammation, oxidative stress, and intestinal microbiota dysbiosis. Current treatments using chemotherapeutic drugs or immunosuppressants have limited effectiveness and side effects. Therefore...

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Bibliographic Details
Main Authors: Bowen Gao, Xiaoling Huang, Junlong Fu, Liyuan Chen, Zhichao Deng, Shuhui Wang, Yuanyuan Zhu, Chenxi Xu, Yujie Zhang, Mingxin Zhang, Lina Chen, Manli Cui, Mingzhen Zhang
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Journal of Nanobiotechnology
Subjects:
Ulcerative colitis
Momordica charantia-derived extracellular vesicles (MCEVs)
Anti-oxidation
Anti-inflammation
Microbiota
Online Access:https://doi.org/10.1186/s12951-025-03346-6
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