Fermented sugarcane juice-derived probiotic Levilactobacillus brevis RAMULAB54 enhances lipid metabolism and glucose homeostasis through PPAR-γ activation

Fermented sugarcane juice-derived probiotic Levilactobacillus brevis RAMULAB54 enhances lipid metabolism and glucose homeostasis through PPAR-γ activation

The gut microbiota plays a significant role in metabolic disorders such as diabetes and obesity, with the peroxisome proliferator-activated receptor gamma (PPAR-γ) being a key regulator in adipogenesis and glucose metabolism. This study is a novel approach that explores the antihyperglycemic and ant...

Full description

Saved in:

Bibliographic Details
Main Authors:	V. B. Chandana Kumari, Ramith Ramu, Sujay S. Huligere, Shashank M. Patil, Shivasharanappa Nayakvadi, Sharath Bijoor, Uma Venkateswaran Manjappara, Mohammad Z. Ahmed, Ling Shing Wong
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-01-01
Series:	Frontiers in Microbiology
Subjects:	gut microbiota PPAR-γ modulation obesity diabetes hyperlipidemia hyperglycemia
Online Access:	https://www.frontiersin.org/articles/10.3389/fmicb.2024.1502751/full
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

The protective effects of Levilactobacillus brevis FZU0713 on lipid metabolism and intestinal microbiota in hyperlipidemic rats
by: Xiaoyun Fan, et al.
Published: (2023-09-01)

Black rice (Oryza sativa L.) and its anthocyanins: mechanisms, food applications, and clinical insights for postprandial glycemic and lipid regulation
by: Thavaree Thilavech, et al.
Published: (2025-02-01)

Characterization of Lactobacillus spp. as Probiotic and Antidiabetic Potential Isolated from Boza, Traditional Fermented Beverage in Turkey
by: Chandana Kumari V. B., et al.
Published: (2024-01-01)

Clinical profile of stress hyperglycemia in medical intensive care units
by: Geethanjali Ganesan, et al.
Published: (2025-03-01)

Levilactobacillus brevis CD2 as a multifaceted probiotic to preserve oral health: results of a double-blind, randomized, placebo-controlled trial in healthy adults
by: Serena Altamura, et al.
Published: (2025-01-01)

Supplementation of dairy cows with bovine somatotropin or omega-3 rich fish oil affects the endometrial expression of peroxisome proliferator-activated receptors
by: Leslie A. MacLaren, et al.

Potential involvement of peroxisome proliferator-activated receptors in the inhibition of mammary lipid synthesis during diet-induced milk fat depression
by: A. Haile, et al.
Published: (2025-02-01)

The effect of lemon extract (Citrus limon) on the blood sugar levels and pancreatic beta cell regeneration in alloxan-induced hyperglycemic mice
by: Petrus Mantur, et al.
Published: (2023-08-01)

Immune-endocrine crossroads: the impact of nuclear receptors in Tuberculosis and Chagas disease
by: Ana R. Pérez, et al.
Published: (2025-02-01)

Evaluation of C-X-C chemokine receptor type 4 (CXCR4) and Peroxisome proliferator-activated receptor gamma (PPAR-γ) expression in colorectal carcinoma: Relation to the available clinicopathological parameters
by: Asmaa E. Bedeer, et al.
Published: (2023-07-01)

Anti-Hyperlipidemic Effect of Zinc complex of Betulinic acid in High Fat Diet- Induced Hyperlipidemia
by: Mehwish Tayyab, et al.
Published: (2023-04-01)

Auricularia polytricha noodles prevent hyperlipemia and modulate gut microbiota in high-fat diet fed mice
by: Donglu Fang, et al.
Published: (2021-07-01)

Frameshift variation in the HMG-CoA reductase gene and unresponsiveness to cholesterol-lowering drugs in type 2 diabetes mellitus patients
by: Esmat Khaleqsefat, et al.
Published: (2025-01-01)

Management recommendations to reduce cardiac risk in chronic epilepsy
by: Trudy D. Pang, et al.
Published: (2025-03-01)

The association between obesity indicators and mortality among individuals with hyperlipidemia: evidence from the NHANES 2003–2018
by: Yiheng Zhang, et al.
Published: (2025-01-01)

Automated process assessment of primary healthcare for hyperlipidemia: preliminary findings and implications form Anhui, China
by: Ningjing Yang, et al.
Published: (2025-01-01)

Nutritional Factors Related to Canine Gallbladder Diseases—A Scoping Review
by: Fabio Alves Teixeira, et al.
Published: (2024-12-01)

Hypoglychemic activity of Moringa oleifera extract in streptozotocin-induced diabetic rats
by: Rabiatul Adawiyah, et al.
Published: (2024-08-01)

Combined effect of healthy lifestyles and obesity on cardiometabolic risks in Chinese rural adults
by: Hui Fan, et al.
Published: (2025-01-01)

A novel protein encoded by porcine circANKRD17 activates the PPAR pathway to regulate intramuscular fat metabolism
by: Xiao He, et al.
Published: (2025-02-01)

Racconti brevi
by: Maria Rosaria Faggiano
Published: (2024-12-01)

Prophylactic and therapeutic effects of EsV3 on atherosclerotic lesions in ApoE−/− mice
by: Yaze Wang, et al.
Published: (2025-01-01)

Exploring the role of curcumin in mitigating oxidative stress to alleviate lipid metabolism disorders
by: Maojun Cheng, et al.
Published: (2025-01-01)

Effect of probiotic-fermented milk containing Lactiplantibacillus pentoses strain HBUAS 53657 on serum glutathione peroxidase activity and pancreatic histopathology in hyperglycemic rats
by: Rita Yaswir, et al.
Published: (2024-12-01)

Diabetic Ketoacidosis in Klinefelter Syndrome Sans Malignancy with Unusually Elevated Levels of CEA: A Case Report
by: Wo X, et al.
Published: (2025-01-01)

Infant of a diabetic mother: clinical presentation, diagnosis and treatment
by: Magdalena Suda-Całus, et al.
Published: (2024-04-01)

Neuroimmune axis: Linking environmental factors to pancreatic β-cell dysfunction in Diabetes
by: Luz Andreone
Published: (2025-02-01)

Diabetes-related cognitive impairment: Mechanisms, symptoms, and treatments
by: Yu Xueting, et al.
Published: (2025-01-01)

Characterization and Probiotic Potential of <i>Levilactobacillus brevis</i> DPL5: A Novel Strain Isolated from Human Breast Milk with Antimicrobial Properties Against Biofilm-Forming <i>Staphylococcus aureus</i>
by: Ivan Iliev, et al.
Published: (2025-01-01)

α-amanitin induces hepatotoxicity via PPAR-γ inhibition and NLRP3 inflammasome activation
by: Haowei Wang, et al.
Published: (2025-01-01)

Modulation of adiposity and adipocyte inflammation by methanol extracts of Alpinia calcarata leaf in high-fat-diet induced-obese mice: Involvement of COX-2 and PPAR-γ
by: Imtiaz Ahmad, et al.
Published: (2025-01-01)

Multi-omics mechanical analysis of gut microbiota, carboxylic acids, and cardiac gene expression interaction triggering diabetic cardiomyopathy
by: Meixin Shi, et al.
Published: (2025-01-01)

Lipid Metabolism Alterations in Hyperlipidemic Dogs with Biliary Tract or Endocrine Diseases
by: Tae-Woo Kim, et al.
Published: (2025-01-01)

Cobalt Protoporphyrin Downregulates Hyperglycemia-Induced Inflammation and Enhances Mitochondrial Respiration in Retinal Pigment Epithelial Cells
by: Peng-Hsiang Fang, et al.
Published: (2025-01-01)

Editorial: Endocrine disruptors in molecular and structural endocrinology
by: Julianne M. Hall
Published: (2025-02-01)

Cinnamic acid alleviates endothelial dysfunction and oxidative stress by targeting PPARδ in obesity and diabetes
by: Yizhen Bai, et al.
Published: (2025-01-01)

Metabolic Activity in Human Intermuscular Adipose Tissue Directs the Response of Resident PPARγ<sup>+</sup> Macrophages to Fatty Acids
by: Xiaoying Chen, et al.
Published: (2024-12-01)

Slow Metabolism–Driven Amplification of Hepatic PPARγ Agonism Mediates Benzbromarone‐Induced Obesity‐Specific Liver Injury
by: Guanting Li, et al.
Published: (2025-01-01)

Efficacy and safety of PCSK9 inhibitors, potent statins, and their combinations for reducing low-density lipoprotein cholesterol in hyperlipidemia patients: a systematic network meta-analysis
by: Yuhua Jiang, et al.
Published: (2025-02-01)

Epidemiological and Genome-Wide Association Study of Gastritis or Gastric Ulcer in Korean Populations
by: Sumin Oh, et al.
Published: (2014-09-01)