Efficacy and tolerability of probiotics, prebiotics, and symbiotics consumption on oral complications of patients with thyroid and head and neck cancers: a systematic review and meta-analysis
Abstract Background Oral complications following cancer treatment are a challenging issue for oncologists. Several studies have demonstrated the efficacy of biotics in the prevention and treatment of oral complications in thyroid and head and neck cancers. Methods Following the PRISMA criteria, a sy...
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| Format: | Article |
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2025-05-01
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| Series: | BMC Oral Health |
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| Online Access: | https://doi.org/10.1186/s12903-025-05876-9 |
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| author | Mohammadreza Shafiei Shayan Mardi Soodeh Ghadimi Helia Poorshahbazi Roozbeh Pourabbas Mohammadamin Keykhah Hosein Rafiemanesh |
| author_facet | Mohammadreza Shafiei Shayan Mardi Soodeh Ghadimi Helia Poorshahbazi Roozbeh Pourabbas Mohammadamin Keykhah Hosein Rafiemanesh |
| author_sort | Mohammadreza Shafiei |
| collection | DOAJ |
| description | Abstract Background Oral complications following cancer treatment are a challenging issue for oncologists. Several studies have demonstrated the efficacy of biotics in the prevention and treatment of oral complications in thyroid and head and neck cancers. Methods Following the PRISMA criteria, a systematic review and meta-analysis of included studies on efficacy, safety, dosage, and duration of treatment was performed. Results A total of 12 randomized controlled trials and a total of 885 individuals were included in this meta-analysis. Our analysis showed that biotics had a slight but insignificant effect on the incidence of oral mucositis (Risk ratio (RR) = 0.90, 95% CI [0.79, 1.03]), and a significant impact on reducing the severity of oral mucositis (RR = 0.62, 95% CI [0.48, 0.80]). Biotics also had a slight but insignificant effect in developing xerostomia in thyroid and Head and neck cancer (HNC) patients. Subgroup meta-analysis demonstrated that Bifidobacterium-containing products were more effective than other blends. Conclusion Our findings demonstrated that biotics are effective and safe for HNC and thyroid patients suffering from oral complications. |
| format | Article |
| id | doaj-art-79bd542542e4428ea3460b0808a9c305 |
| institution | OA Journals |
| issn | 1472-6831 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Oral Health |
| spelling | doaj-art-79bd542542e4428ea3460b0808a9c3052025-08-20T01:47:32ZengBMCBMC Oral Health1472-68312025-05-0125111010.1186/s12903-025-05876-9Efficacy and tolerability of probiotics, prebiotics, and symbiotics consumption on oral complications of patients with thyroid and head and neck cancers: a systematic review and meta-analysisMohammadreza Shafiei0Shayan Mardi1Soodeh Ghadimi2Helia Poorshahbazi3Roozbeh Pourabbas4Mohammadamin Keykhah5Hosein Rafiemanesh6Student Research Committee, School of Medicine, Alborz University of Medical SciencesStudent Research Committee, School of Medicine, Arak University of Medical SciencesSchool of Medicine, Azad University of Medical SciencesStudent Research Committee, School of Medicine, Alborz University of Medical SciencesStudent Research Committee, School of Medicine, Alborz University of Medical SciencesStudent Research Committee, School of Medicine, Alborz University of Medical SciencesNon-communicable Diseases Research Center, Alborz University of Medical SciencesAbstract Background Oral complications following cancer treatment are a challenging issue for oncologists. Several studies have demonstrated the efficacy of biotics in the prevention and treatment of oral complications in thyroid and head and neck cancers. Methods Following the PRISMA criteria, a systematic review and meta-analysis of included studies on efficacy, safety, dosage, and duration of treatment was performed. Results A total of 12 randomized controlled trials and a total of 885 individuals were included in this meta-analysis. Our analysis showed that biotics had a slight but insignificant effect on the incidence of oral mucositis (Risk ratio (RR) = 0.90, 95% CI [0.79, 1.03]), and a significant impact on reducing the severity of oral mucositis (RR = 0.62, 95% CI [0.48, 0.80]). Biotics also had a slight but insignificant effect in developing xerostomia in thyroid and Head and neck cancer (HNC) patients. Subgroup meta-analysis demonstrated that Bifidobacterium-containing products were more effective than other blends. Conclusion Our findings demonstrated that biotics are effective and safe for HNC and thyroid patients suffering from oral complications.https://doi.org/10.1186/s12903-025-05876-9ProbioticsOral complicationsHead and Neck neoplasmsRadiotherapyMeta-Analysis |
| spellingShingle | Mohammadreza Shafiei Shayan Mardi Soodeh Ghadimi Helia Poorshahbazi Roozbeh Pourabbas Mohammadamin Keykhah Hosein Rafiemanesh Efficacy and tolerability of probiotics, prebiotics, and symbiotics consumption on oral complications of patients with thyroid and head and neck cancers: a systematic review and meta-analysis BMC Oral Health Probiotics Oral complications Head and Neck neoplasms Radiotherapy Meta-Analysis |
| title | Efficacy and tolerability of probiotics, prebiotics, and symbiotics consumption on oral complications of patients with thyroid and head and neck cancers: a systematic review and meta-analysis |
| title_full | Efficacy and tolerability of probiotics, prebiotics, and symbiotics consumption on oral complications of patients with thyroid and head and neck cancers: a systematic review and meta-analysis |
| title_fullStr | Efficacy and tolerability of probiotics, prebiotics, and symbiotics consumption on oral complications of patients with thyroid and head and neck cancers: a systematic review and meta-analysis |
| title_full_unstemmed | Efficacy and tolerability of probiotics, prebiotics, and symbiotics consumption on oral complications of patients with thyroid and head and neck cancers: a systematic review and meta-analysis |
| title_short | Efficacy and tolerability of probiotics, prebiotics, and symbiotics consumption on oral complications of patients with thyroid and head and neck cancers: a systematic review and meta-analysis |
| title_sort | efficacy and tolerability of probiotics prebiotics and symbiotics consumption on oral complications of patients with thyroid and head and neck cancers a systematic review and meta analysis |
| topic | Probiotics Oral complications Head and Neck neoplasms Radiotherapy Meta-Analysis |
| url | https://doi.org/10.1186/s12903-025-05876-9 |
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