Fabrication of a Porous Metal-Organic Framework with Polar Channels for 5-Fu Delivery and Inhibiting Human Osteosarcoma Cells
As an emerging kind of crystalline material, the metal-organic framework (MOF) has shown great promise in the biomedical domains such as drug storage and delivery. In this study, a new porous MOF, [[Dy2(H2O)3(SDBA)3](DMA)6] (1, H2SDBA = 4,4′-sulfonyldibenzoic acid, DMA = N,N-dimethylacetamide (C4H9N...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2018-01-01
|
| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2018/1523154 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832555865698205696 |
|---|---|
| author | Li-Chun Zhao Mei Tang Qian-Hua Zhang Zhi-Yi Hu Hong-Wei Gao Xia-Yun Liao Gang Wang Jing Leng |
| author_facet | Li-Chun Zhao Mei Tang Qian-Hua Zhang Zhi-Yi Hu Hong-Wei Gao Xia-Yun Liao Gang Wang Jing Leng |
| author_sort | Li-Chun Zhao |
| collection | DOAJ |
| description | As an emerging kind of crystalline material, the metal-organic framework (MOF) has shown great promise in the biomedical domains such as drug storage and delivery. In this study, a new porous MOF, [[Dy2(H2O)3(SDBA)3](DMA)6] (1, H2SDBA = 4,4′-sulfonyldibenzoic acid, DMA = N,N-dimethylacetamide (C4H9NO)), with uncoordinated O donor sites has been fabricated using a bent polycarboxylic acid organic linker under the solvothermal condition. The structure of the obtained crystalline product has been fully determined by the X-ray single-crystal diffraction, TGA, elemental analysis, XRD, and the gas sorption measurement. Due to the suitable window size and polar atom functionalized 1D channels, the activated 1 (1a) compound was used for the anticancer drug 5-fluorouracil (5-Fu, C4H3FN2O2) loading by a simple impregnation method. A moderate drug loading and pH-dependent drug-release behavior could be observed for 1a. Furthermore, as indicated by the MTT assay, this drug/MOF composite shows low toxicity toward the human normal cells and demonstrates obvious anticancer activity against the human osteosarcoma cell line MG63. |
| format | Article |
| id | doaj-art-79b93c36d779403bad7c419bd11198b9 |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-79b93c36d779403bad7c419bd11198b92025-02-03T05:46:58ZengWileyJournal of Chemistry2090-90632090-90712018-01-01201810.1155/2018/15231541523154Fabrication of a Porous Metal-Organic Framework with Polar Channels for 5-Fu Delivery and Inhibiting Human Osteosarcoma CellsLi-Chun Zhao0Mei Tang1Qian-Hua Zhang2Zhi-Yi Hu3Hong-Wei Gao4Xia-Yun Liao5Gang Wang6Jing Leng7College of Pharmacy, Guangxi University of Chinese Medicine, Nanning 530200, ChinaCollege of Pharmacy, Guangxi University of Chinese Medicine, Nanning 530200, ChinaCollege of Pharmacy, Guangxi University of Chinese Medicine, Nanning 530200, ChinaCollege of Pharmacy, Guangxi University of Chinese Medicine, Nanning 530200, ChinaCollege of Pharmacy, Guangxi University of Chinese Medicine, Nanning 530200, ChinaCollege of Pharmacy, Guangxi University of Chinese Medicine, Nanning 530200, ChinaCollege of Pharmacy, Guangxi University of Chinese Medicine, Nanning 530200, ChinaCollege of Pharmacy, Guangxi University of Chinese Medicine, Nanning 530200, ChinaAs an emerging kind of crystalline material, the metal-organic framework (MOF) has shown great promise in the biomedical domains such as drug storage and delivery. In this study, a new porous MOF, [[Dy2(H2O)3(SDBA)3](DMA)6] (1, H2SDBA = 4,4′-sulfonyldibenzoic acid, DMA = N,N-dimethylacetamide (C4H9NO)), with uncoordinated O donor sites has been fabricated using a bent polycarboxylic acid organic linker under the solvothermal condition. The structure of the obtained crystalline product has been fully determined by the X-ray single-crystal diffraction, TGA, elemental analysis, XRD, and the gas sorption measurement. Due to the suitable window size and polar atom functionalized 1D channels, the activated 1 (1a) compound was used for the anticancer drug 5-fluorouracil (5-Fu, C4H3FN2O2) loading by a simple impregnation method. A moderate drug loading and pH-dependent drug-release behavior could be observed for 1a. Furthermore, as indicated by the MTT assay, this drug/MOF composite shows low toxicity toward the human normal cells and demonstrates obvious anticancer activity against the human osteosarcoma cell line MG63.http://dx.doi.org/10.1155/2018/1523154 |
| spellingShingle | Li-Chun Zhao Mei Tang Qian-Hua Zhang Zhi-Yi Hu Hong-Wei Gao Xia-Yun Liao Gang Wang Jing Leng Fabrication of a Porous Metal-Organic Framework with Polar Channels for 5-Fu Delivery and Inhibiting Human Osteosarcoma Cells Journal of Chemistry |
| title | Fabrication of a Porous Metal-Organic Framework with Polar Channels for 5-Fu Delivery and Inhibiting Human Osteosarcoma Cells |
| title_full | Fabrication of a Porous Metal-Organic Framework with Polar Channels for 5-Fu Delivery and Inhibiting Human Osteosarcoma Cells |
| title_fullStr | Fabrication of a Porous Metal-Organic Framework with Polar Channels for 5-Fu Delivery and Inhibiting Human Osteosarcoma Cells |
| title_full_unstemmed | Fabrication of a Porous Metal-Organic Framework with Polar Channels for 5-Fu Delivery and Inhibiting Human Osteosarcoma Cells |
| title_short | Fabrication of a Porous Metal-Organic Framework with Polar Channels for 5-Fu Delivery and Inhibiting Human Osteosarcoma Cells |
| title_sort | fabrication of a porous metal organic framework with polar channels for 5 fu delivery and inhibiting human osteosarcoma cells |
| url | http://dx.doi.org/10.1155/2018/1523154 |
| work_keys_str_mv | AT lichunzhao fabricationofaporousmetalorganicframeworkwithpolarchannelsfor5fudeliveryandinhibitinghumanosteosarcomacells AT meitang fabricationofaporousmetalorganicframeworkwithpolarchannelsfor5fudeliveryandinhibitinghumanosteosarcomacells AT qianhuazhang fabricationofaporousmetalorganicframeworkwithpolarchannelsfor5fudeliveryandinhibitinghumanosteosarcomacells AT zhiyihu fabricationofaporousmetalorganicframeworkwithpolarchannelsfor5fudeliveryandinhibitinghumanosteosarcomacells AT hongweigao fabricationofaporousmetalorganicframeworkwithpolarchannelsfor5fudeliveryandinhibitinghumanosteosarcomacells AT xiayunliao fabricationofaporousmetalorganicframeworkwithpolarchannelsfor5fudeliveryandinhibitinghumanosteosarcomacells AT gangwang fabricationofaporousmetalorganicframeworkwithpolarchannelsfor5fudeliveryandinhibitinghumanosteosarcomacells AT jingleng fabricationofaporousmetalorganicframeworkwithpolarchannelsfor5fudeliveryandinhibitinghumanosteosarcomacells |