PBMCs gene expression predicts liver fibrosis regression after successful HCV therapy in HIV/HCV-coinfected patients

PBMCs gene expression predicts liver fibrosis regression after successful HCV therapy in HIV/HCV-coinfected patients

BackgroundHCV eradication with antiviral treatment reduces hepatic disease, but some patients remain at risk of progression to cirrhosis despite HCV clearance. We aimed to examine the association between peripheral blood mononuclear cells (PBMCs) gene expression before HCV therapy and a pronounced d...

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Main Authors: Ana Virseda-Berdices, Óscar Brochado-Kith, Juan Berenguer, Juan González-García, Leire Pérez-Latorre, Carmen Busca, Cristina Díez, Rafael Micán, Amanda Fernández-Rodríguez, María Ángeles Jiménez-Sousa, Salvador Resino
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Pharmacology
Subjects:
HIV/HCV coinfection
gene expression
RNA-seq
PBMCs
liver stiffness
HCV treatment
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1436198/full
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