Association of Life’s Essential 8 Score with All-Cause and Cardiovascular Mortality in Patients with Diabetic Nephropathy: A NHANES-Based Cohort Study
Fan Zhang,1,2 Wenjian Li3,4 1Department of Endocrinology, Changzhou Third People’s Hospital, Changzhou, Jiangsu, People’s Republic of China; 2Department of Clinical Nutrition, Changzhou Third People’s Hospital, Changzhou, Jiangsu, People’s Republic of China; 3Department of Urology, Changzhou Third P...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2025-08-01
|
| Series: | Journal of Multidisciplinary Healthcare |
| Subjects: | |
| Online Access: | https://www.dovepress.com/association-of-lifes-essential-8-score-with-all-cause-and-cardiovascul-peer-reviewed-fulltext-article-JMDH |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850033172912275456 |
|---|---|
| author | Zhang F Li W |
| author_facet | Zhang F Li W |
| author_sort | Zhang F |
| collection | DOAJ |
| description | Fan Zhang,1,2 Wenjian Li3,4 1Department of Endocrinology, Changzhou Third People’s Hospital, Changzhou, Jiangsu, People’s Republic of China; 2Department of Clinical Nutrition, Changzhou Third People’s Hospital, Changzhou, Jiangsu, People’s Republic of China; 3Department of Urology, Changzhou Third People’s Hospital, Changzhou, Jiangsu, People’s Republic of China; 4Changzhou Clinical College, Xuzhou Medical University, Changzhou, Jiangsu, People’s Republic of ChinaCorrespondence: Wenjian Li, Department of Urology, Changzhou Third People’s Hospital, 300 Lanling North Road, Changzhou, Jiangsu, 213001, People’s Republic of China, Tel +86-0519-82009011, Email bolite@163.comPurpose: This study aimed to assess the relationship between the “Life’s Essential 8” (LE8) score and all-cause and cardiovascular mortality in patients with diabetic nephropathy (DN).Methods: This observational cohort study utilized data from the National Health and Nutrition Examination Survey (NHANES, 2005– 2018). A total of 1,745 patients with DN were included. The LE8 score encompassed health behaviors (diet, physical activity, nicotine control, sleep) and physiological indices (body mass index, non-high-density lipoprotein cholesterol, blood glucose, blood pressure). A multivariate Cox proportional risk model was employed to assess the effect of the LE8 score on the risk of death, and the dose-response relationship was analyzed by a restricted cubic spline (RCS) model. Subgroup analyses and multiple imputations were performed to verify the robustness of the findings.Results: After adjusting for confounders, a 10-point increase in the LE8 score was associated with a 12% reduction in the risk of all-cause mortality [hazard ratio (HR) = 0.88, P < 0.001] and a 16% reduction in the risk of cardiovascular death (HR = 0.84, P = 0.007). The risk of all-cause mortality was 33% lower in the highest tertile group compared with the lowest group (HR = 0.67, P < 0.001), and the risk of cardiovascular mortality was 36% lower (HR = 0.64, P = 0.014). RCS analysis showed that LE8 scores were linearly negatively correlated with mortality (nonlinear P > 0.05). Subgroup analyses further confirmed the consistency of this association across various characteristic subgroups.Conclusion: LE8 score has been identified as an independent protective factor for the risk of death in patients with DN, exhibiting a linear dose-response relationship consistent across sociodemographic subgroups. This finding underscores the importance of incorporating LE8 into a comprehensive assessment system for DN patients, providing a foundation for precision intervention.Keywords: diabetic nephropathy, life’s essential 8, all-cause mortality, cardiovascular mortality, cohort studies |
| format | Article |
| id | doaj-art-79a98e88d7954c5aa2c8a2a2f30e262a |
| institution | DOAJ |
| issn | 1178-2390 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Journal of Multidisciplinary Healthcare |
| spelling | doaj-art-79a98e88d7954c5aa2c8a2a2f30e262a2025-08-20T02:58:18ZengDove Medical PressJournal of Multidisciplinary Healthcare1178-23902025-08-01Volume 18Issue 147954808105505Association of Life&rsquo;s Essential 8 Score with All-Cause and Cardiovascular Mortality in Patients with Diabetic Nephropathy: A NHANES-Based Cohort StudyZhang F0Li W1Department of EndocrinologyDepartment of UrologyFan Zhang,1,2 Wenjian Li3,4 1Department of Endocrinology, Changzhou Third People’s Hospital, Changzhou, Jiangsu, People’s Republic of China; 2Department of Clinical Nutrition, Changzhou Third People’s Hospital, Changzhou, Jiangsu, People’s Republic of China; 3Department of Urology, Changzhou Third People’s Hospital, Changzhou, Jiangsu, People’s Republic of China; 4Changzhou Clinical College, Xuzhou Medical University, Changzhou, Jiangsu, People’s Republic of ChinaCorrespondence: Wenjian Li, Department of Urology, Changzhou Third People’s Hospital, 300 Lanling North Road, Changzhou, Jiangsu, 213001, People’s Republic of China, Tel +86-0519-82009011, Email bolite@163.comPurpose: This study aimed to assess the relationship between the “Life’s Essential 8” (LE8) score and all-cause and cardiovascular mortality in patients with diabetic nephropathy (DN).Methods: This observational cohort study utilized data from the National Health and Nutrition Examination Survey (NHANES, 2005– 2018). A total of 1,745 patients with DN were included. The LE8 score encompassed health behaviors (diet, physical activity, nicotine control, sleep) and physiological indices (body mass index, non-high-density lipoprotein cholesterol, blood glucose, blood pressure). A multivariate Cox proportional risk model was employed to assess the effect of the LE8 score on the risk of death, and the dose-response relationship was analyzed by a restricted cubic spline (RCS) model. Subgroup analyses and multiple imputations were performed to verify the robustness of the findings.Results: After adjusting for confounders, a 10-point increase in the LE8 score was associated with a 12% reduction in the risk of all-cause mortality [hazard ratio (HR) = 0.88, P < 0.001] and a 16% reduction in the risk of cardiovascular death (HR = 0.84, P = 0.007). The risk of all-cause mortality was 33% lower in the highest tertile group compared with the lowest group (HR = 0.67, P < 0.001), and the risk of cardiovascular mortality was 36% lower (HR = 0.64, P = 0.014). RCS analysis showed that LE8 scores were linearly negatively correlated with mortality (nonlinear P > 0.05). Subgroup analyses further confirmed the consistency of this association across various characteristic subgroups.Conclusion: LE8 score has been identified as an independent protective factor for the risk of death in patients with DN, exhibiting a linear dose-response relationship consistent across sociodemographic subgroups. This finding underscores the importance of incorporating LE8 into a comprehensive assessment system for DN patients, providing a foundation for precision intervention.Keywords: diabetic nephropathy, life’s essential 8, all-cause mortality, cardiovascular mortality, cohort studieshttps://www.dovepress.com/association-of-lifes-essential-8-score-with-all-cause-and-cardiovascul-peer-reviewed-fulltext-article-JMDHdiabetic nephropathyLife's Essential 8all-cause mortalitycardiovascular mortalitycohort studies |
| spellingShingle | Zhang F Li W Association of Life&rsquo;s Essential 8 Score with All-Cause and Cardiovascular Mortality in Patients with Diabetic Nephropathy: A NHANES-Based Cohort Study Journal of Multidisciplinary Healthcare diabetic nephropathy Life's Essential 8 all-cause mortality cardiovascular mortality cohort studies |
| title | Association of Life&rsquo;s Essential 8 Score with All-Cause and Cardiovascular Mortality in Patients with Diabetic Nephropathy: A NHANES-Based Cohort Study |
| title_full | Association of Life&rsquo;s Essential 8 Score with All-Cause and Cardiovascular Mortality in Patients with Diabetic Nephropathy: A NHANES-Based Cohort Study |
| title_fullStr | Association of Life&rsquo;s Essential 8 Score with All-Cause and Cardiovascular Mortality in Patients with Diabetic Nephropathy: A NHANES-Based Cohort Study |
| title_full_unstemmed | Association of Life&rsquo;s Essential 8 Score with All-Cause and Cardiovascular Mortality in Patients with Diabetic Nephropathy: A NHANES-Based Cohort Study |
| title_short | Association of Life&rsquo;s Essential 8 Score with All-Cause and Cardiovascular Mortality in Patients with Diabetic Nephropathy: A NHANES-Based Cohort Study |
| title_sort | association of life amp rsquo s essential 8 score with all cause and cardiovascular mortality in patients with diabetic nephropathy a nhanes based cohort study |
| topic | diabetic nephropathy Life's Essential 8 all-cause mortality cardiovascular mortality cohort studies |
| url | https://www.dovepress.com/association-of-lifes-essential-8-score-with-all-cause-and-cardiovascul-peer-reviewed-fulltext-article-JMDH |
| work_keys_str_mv | AT zhangf associationoflifeamprsquosessential8scorewithallcauseandcardiovascularmortalityinpatientswithdiabeticnephropathyanhanesbasedcohortstudy AT liw associationoflifeamprsquosessential8scorewithallcauseandcardiovascularmortalityinpatientswithdiabeticnephropathyanhanesbasedcohortstudy |