Increased Incidence of Thyroid Dysfunction and Autoimmunity in Patients with Vernal Keratoconjunctivitis
Hormones may play a role in the pathophysiology of vernal keratoconjunctivitis (VKC). An increased incidence of thyroid autoantibodies was recently observed in VKC, although there were no data on thyroid function. Two hundred and eighty-eight patients (202 males, 86 females; range 5.5 to 16.9 years)...
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Wiley
2014-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2014/804870 |
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| author | Stefano Stagi Neri Pucci Laura Di Grande Cinzia de Libero Roberto Caputo Stefano Pantano Ivan Mattei Francesca Mori Maurizio de Martino Elio Novembre |
| author_facet | Stefano Stagi Neri Pucci Laura Di Grande Cinzia de Libero Roberto Caputo Stefano Pantano Ivan Mattei Francesca Mori Maurizio de Martino Elio Novembre |
| author_sort | Stefano Stagi |
| collection | DOAJ |
| description | Hormones may play a role in the pathophysiology of vernal keratoconjunctivitis (VKC). An increased incidence of thyroid autoantibodies was recently observed in VKC, although there were no data on thyroid function. Two hundred and eighty-eight patients (202 males, 86 females; range 5.5 to 16.9 years) with VKC were evaluated and compared with 188 normal age- and sex-matched subjects. In all subjects, serum concentrations of free T4, TSH, thyroperoxidase, thyroglobulin, and TSHr autoantibodies were evaluated. In VKC, the family history of thyroid diseases showed no significant differences compared to the controls (9.4 versus 8.6%), whereas the family history of autoimmune diseases was significantly higher (13.2% versus 6.3%; P<0.05). Subclinical hypothyroidism was diagnosed in 6.6% (versus 1.6% of the controls; P<0.05) and overt hypothyroidism in 0.7% (versus 0.0% of the controls; P=NS). Finally, 5.2% of patients were positive for thyroid autoantibodies, which were significantly higher with respect to the controls (0.5%, P<0.05). In the patients positive for thyroid autoantibodies, 80% showed a sonography pattern that suggested autoimmune thyroiditis. Thyroid function and autoimmunity abnormalities are frequently present in children with VKC. Children with VKC should be screened for thyroid function and evaluated for thyroid autoimmunity. |
| format | Article |
| id | doaj-art-79a66198763048acb5b354365b9f87c4 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-79a66198763048acb5b354365b9f87c42025-02-03T06:12:09ZengWileyInternational Journal of Endocrinology1687-83371687-83452014-01-01201410.1155/2014/804870804870Increased Incidence of Thyroid Dysfunction and Autoimmunity in Patients with Vernal KeratoconjunctivitisStefano Stagi0Neri Pucci1Laura Di Grande2Cinzia de Libero3Roberto Caputo4Stefano Pantano5Ivan Mattei6Francesca Mori7Maurizio de Martino8Elio Novembre9Department of Health Sciences, University of Florence, Anna Meyer Children’s University Hospital, Viale Pieraccini 24, 50139 Florence, ItalyDepartment of Health Sciences, University of Florence, Anna Meyer Children’s University Hospital, Viale Pieraccini 24, 50139 Florence, ItalyDepartment of Health Sciences, University of Florence, Anna Meyer Children’s University Hospital, Viale Pieraccini 24, 50139 Florence, ItalyClinical Ophthalmology Unit, Anna Meyer Children’s University Hospital, Viale Pieraccini 24, 50139 Florence, ItalyClinical Ophthalmology Unit, Anna Meyer Children’s University Hospital, Viale Pieraccini 24, 50139 Florence, ItalyDepartment of Health Sciences, University of Florence, Anna Meyer Children’s University Hospital, Viale Pieraccini 24, 50139 Florence, ItalyDepartment of Health Sciences, University of Florence, Anna Meyer Children’s University Hospital, Viale Pieraccini 24, 50139 Florence, ItalyDepartment of Health Sciences, University of Florence, Anna Meyer Children’s University Hospital, Viale Pieraccini 24, 50139 Florence, ItalyDepartment of Health Sciences, University of Florence, Anna Meyer Children’s University Hospital, Viale Pieraccini 24, 50139 Florence, ItalyDepartment of Health Sciences, University of Florence, Anna Meyer Children’s University Hospital, Viale Pieraccini 24, 50139 Florence, ItalyHormones may play a role in the pathophysiology of vernal keratoconjunctivitis (VKC). An increased incidence of thyroid autoantibodies was recently observed in VKC, although there were no data on thyroid function. Two hundred and eighty-eight patients (202 males, 86 females; range 5.5 to 16.9 years) with VKC were evaluated and compared with 188 normal age- and sex-matched subjects. In all subjects, serum concentrations of free T4, TSH, thyroperoxidase, thyroglobulin, and TSHr autoantibodies were evaluated. In VKC, the family history of thyroid diseases showed no significant differences compared to the controls (9.4 versus 8.6%), whereas the family history of autoimmune diseases was significantly higher (13.2% versus 6.3%; P<0.05). Subclinical hypothyroidism was diagnosed in 6.6% (versus 1.6% of the controls; P<0.05) and overt hypothyroidism in 0.7% (versus 0.0% of the controls; P=NS). Finally, 5.2% of patients were positive for thyroid autoantibodies, which were significantly higher with respect to the controls (0.5%, P<0.05). In the patients positive for thyroid autoantibodies, 80% showed a sonography pattern that suggested autoimmune thyroiditis. Thyroid function and autoimmunity abnormalities are frequently present in children with VKC. Children with VKC should be screened for thyroid function and evaluated for thyroid autoimmunity.http://dx.doi.org/10.1155/2014/804870 |
| spellingShingle | Stefano Stagi Neri Pucci Laura Di Grande Cinzia de Libero Roberto Caputo Stefano Pantano Ivan Mattei Francesca Mori Maurizio de Martino Elio Novembre Increased Incidence of Thyroid Dysfunction and Autoimmunity in Patients with Vernal Keratoconjunctivitis International Journal of Endocrinology |
| title | Increased Incidence of Thyroid Dysfunction and Autoimmunity in Patients with Vernal Keratoconjunctivitis |
| title_full | Increased Incidence of Thyroid Dysfunction and Autoimmunity in Patients with Vernal Keratoconjunctivitis |
| title_fullStr | Increased Incidence of Thyroid Dysfunction and Autoimmunity in Patients with Vernal Keratoconjunctivitis |
| title_full_unstemmed | Increased Incidence of Thyroid Dysfunction and Autoimmunity in Patients with Vernal Keratoconjunctivitis |
| title_short | Increased Incidence of Thyroid Dysfunction and Autoimmunity in Patients with Vernal Keratoconjunctivitis |
| title_sort | increased incidence of thyroid dysfunction and autoimmunity in patients with vernal keratoconjunctivitis |
| url | http://dx.doi.org/10.1155/2014/804870 |
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