Development of a prognostic risk stratification model for HER2-positive breast cancer brain metastasis and its implications in guiding treatment decisions

Development of a prognostic risk stratification model for HER2-positive breast cancer brain metastasis and its implications in guiding treatment decisions

Abstract Brain metastasis occurs in approximately 50% of patients with advanced HER2-positive breast cancer. Despite improved prognosis, survival remains limited. This study aims to investigate the clinicopathological characteristics of HER2-positive breast cancer brain metastasis (BCBM) patients an...

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Bibliographic Details
Main Authors: Jiaxin Chen, Yuan Sh, Danfeng Dong, Huicui Yan, Huiqiang Zhang, Zisheng Wu, Jinmei Zhou, Xuexue Wu, Fei Chu, Zefei Jiang, Shanhu Li, Jin Yang, Ling Xu, Tao Wang
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Human epidermal growth factor receptor 2-positive
Breast cancer
Brain metastasis
Prognostic model
Online Access:https://doi.org/10.1038/s41598-025-06645-y
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