The Effect of Various Implant Coatings on Bone Formation and Cell Adhesion
Background: Dental implants are widely used in restorative dentistry; however, the success of implant integration depends significantly on the interaction between the implant surface and surrounding bone. Various coatings, including hydroxyapatite (HA), titanium dioxide (TiO2), and zirconia, are des...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2025-06-01
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| Series: | Journal of Pharmacy and Bioallied Sciences |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/jpbs.jpbs_230_25 |
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| Summary: | Background:
Dental implants are widely used in restorative dentistry; however, the success of implant integration depends significantly on the interaction between the implant surface and surrounding bone. Various coatings, including hydroxyapatite (HA), titanium dioxide (TiO2), and zirconia, are designed to enhance osseointegration and cell adhesion. This study aimed to evaluate the effect of different implant coatings on bone formation and cellular adhesion.
Materials and Methods:
In this in vitro and in vivo study, titanium implants with three types of coatings—HA, TiO2, and zirconia—were analyzed. For the in vitro analysis, osteoblast-like cells were cultured on coated implants, and adhesion was measured using fluorescence microscopy. The in vivo study involved implant placement in 30 rabbits (10 implants per group) and the assessment of bone formation through histomorphometric analysis after 8 weeks. Arbitrary measurements included cell adhesion rates (%), bone-implant contact (BIC) percentage, and new bone volume formation.
Results:
In vitro cell adhesion rates were highest in HA-coated implants (85%), followed by TiO2 (70%) and zirconia (65%). Histomorphometric analysis revealed that HA-coated implants had the highest BIC percentage (75%), compared to TiO2 (65%) and zirconia (60%). New bone volume formation showed similar trends, with HA-coated implants demonstrating 40% greater bone growth compared to uncoated implants. Statistical analysis indicated significant differences between all groups (P < 0.05).
Conclusion:
Implant coatings significantly influence bone formation and cell adhesion, with HA-coated implants showing superior performance. These findings highlight the importance of surface modifications in improving the success of dental implants. |
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| ISSN: | 0976-4879 0975-7406 |