Aurora kinase B is required for growth and expansion of medulloblastoma cells in the tissue context

Aurora kinase B is required for growth and expansion of medulloblastoma cells in the tissue context

The impact of the tissue context on tumor growth and drug response in medulloblastoma (MB) is poorly understood. To gain insights into the growth and dissemination behavior of the MB tumor cells under treatment, we combined three-dimensional cell culture screening with ex vivo organotypic cerebellum...

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Bibliographic Details
Main Authors: Alexandre Gries, Karthiga Santhana Kumar, Fabien Kuttler, Özgün Özalp, Veronica Akle, Hanqing Zhang, Michael A. Grotzer, Stephan C.F. Neuhauss, Amin Allalou, Martin Baumgartner
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Medulloblastoma
aurora kinase B
organotypic cerebellum slice culture
radiation therapy replacement
zebrafish larval model
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558624001192
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