Platelet-derived HMGB1 induces NETosis, exacerbating brain damage in the photothrombotic stroke model

Platelet-derived HMGB1 induces NETosis, exacerbating brain damage in the photothrombotic stroke model

Abstract Following cerebral ischemia, neutrophil extracellular traps (NETs) contribute significantly to brain damage by exacerbating delayed immune cell infiltration and vascular injury. They are detected both in brain tissue and within blood vessels. Danger-associated molecular pattern (DAMP) molec...

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Bibliographic Details
Main Authors: Sang-A. Oh, Song-I. Seol, Dashdulam Davaanyam, Seung-Woo Kim, Ja-Kyeong Lee
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Molecular Medicine
Subjects:
HMGB1
NETosis
Photothrombosis
Platelet
TLR4
Online Access:https://doi.org/10.1186/s10020-025-01107-7
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