Safe model based optimization balancing exploration and reliability for protein sequence design
Abstract Discovering proteins with desired functionalities using protein engineering is time-consuming. Offline Model-Based Optimization (MBO) accelerates protein sequence design by exploring the vast protein sequence space using a trained proxy model. However, the proxy model often yields excessive...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-07-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-025-12568-5 |
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