Surgical trends, outcomes and disparities in minimal invasive surgery for patients with endometrial cancer in England: a retrospective cohort study
Objective To examine surgical outcomes and trends in the implementation of minimally invasive surgery (MIS) use for endometrial cancer (EC).Design Retrospective cohort study.Setting English National Health Service hospitals 2011–2017/2018.Population 35 304 patients having a hysterectomy for EC ident...
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BMJ Publishing Group
2020-09-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/10/9/e036222.full |
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| author | Thomas Ind Esther L. Moss George Morgan Antony P. Martin Panos Sarhanis |
| author_facet | Thomas Ind Esther L. Moss George Morgan Antony P. Martin Panos Sarhanis |
| author_sort | Thomas Ind |
| collection | DOAJ |
| description | Objective To examine surgical outcomes and trends in the implementation of minimally invasive surgery (MIS) use for endometrial cancer (EC).Design Retrospective cohort study.Setting English National Health Service hospitals 2011–2017/2018.Population 35 304 patients having a hysterectomy for EC identified from Hospital Episode Statistics.Methods Univariate and multivariate analyses compared MIS to open hysterectomy (OH) by assessing the association between demographic, clinical and hospital characteristics by using logistic regression. A propensity score was created, to control for confounding factors including demographics, clinical and hospital characteristics, from a logistic regression which enabled the inverse probability weighting of treatment to be applied in order to compare outcomes of treatment.Main outcome measures The association between route of surgery on perioperative morbidity and mortality.Results The MIS rate rose from 40.3% in 2011 to 68.7% in 2017/2018, however, there was significant geographical variation (p<0.001). The overall 90-day mortality was significantly higher with OH versus MIS (OR 0.34, 95% CI 0.18 to 0.62, p=0.0002). MIS rates were significantly lower in patients from the lowest socioeconomic group (LSEG) compared with patients from the highest group (HSEG) (55.4% vs 59.9%, p<0.01), and in the black population as compared with white and Asian populations (40.4% vs 58.6% and 56.0%, p<0.0001). When patients from LSEG and black patients were treated in hospitals with high MIS rates, the MIS rate increased close to that of the HSEG and white patients (81.0% and 74.1% vs 83.2% and 82.6%).Conclusions Further investigation is needed to understand the barriers to MIS and improve access so that as many patients as possible can benefit from the reduced morbidity/mortality associated with MIS. |
| format | Article |
| id | doaj-art-799c4f862035419da448f7c4ee422ba2 |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2020-09-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-799c4f862035419da448f7c4ee422ba22025-01-08T14:10:08ZengBMJ Publishing GroupBMJ Open2044-60552020-09-0110910.1136/bmjopen-2019-036222Surgical trends, outcomes and disparities in minimal invasive surgery for patients with endometrial cancer in England: a retrospective cohort studyThomas Ind0Esther L. Moss1George Morgan2Antony P. Martin3Panos Sarhanis4Department of Gynaecological Oncology, Royal Marsden Hospital, London, UKLeicester Cancer Research Centre, University of Leicester, Leicester, UKHCD Economics, Daresbury, Cheshire, UKHCD Economics, Warrington, UKDepartment of Gynaecology, North West London Hospitals NHS Trust, London, UKObjective To examine surgical outcomes and trends in the implementation of minimally invasive surgery (MIS) use for endometrial cancer (EC).Design Retrospective cohort study.Setting English National Health Service hospitals 2011–2017/2018.Population 35 304 patients having a hysterectomy for EC identified from Hospital Episode Statistics.Methods Univariate and multivariate analyses compared MIS to open hysterectomy (OH) by assessing the association between demographic, clinical and hospital characteristics by using logistic regression. A propensity score was created, to control for confounding factors including demographics, clinical and hospital characteristics, from a logistic regression which enabled the inverse probability weighting of treatment to be applied in order to compare outcomes of treatment.Main outcome measures The association between route of surgery on perioperative morbidity and mortality.Results The MIS rate rose from 40.3% in 2011 to 68.7% in 2017/2018, however, there was significant geographical variation (p<0.001). The overall 90-day mortality was significantly higher with OH versus MIS (OR 0.34, 95% CI 0.18 to 0.62, p=0.0002). MIS rates were significantly lower in patients from the lowest socioeconomic group (LSEG) compared with patients from the highest group (HSEG) (55.4% vs 59.9%, p<0.01), and in the black population as compared with white and Asian populations (40.4% vs 58.6% and 56.0%, p<0.0001). When patients from LSEG and black patients were treated in hospitals with high MIS rates, the MIS rate increased close to that of the HSEG and white patients (81.0% and 74.1% vs 83.2% and 82.6%).Conclusions Further investigation is needed to understand the barriers to MIS and improve access so that as many patients as possible can benefit from the reduced morbidity/mortality associated with MIS.https://bmjopen.bmj.com/content/10/9/e036222.full |
| spellingShingle | Thomas Ind Esther L. Moss George Morgan Antony P. Martin Panos Sarhanis Surgical trends, outcomes and disparities in minimal invasive surgery for patients with endometrial cancer in England: a retrospective cohort study BMJ Open |
| title | Surgical trends, outcomes and disparities in minimal invasive surgery for patients with endometrial cancer in England: a retrospective cohort study |
| title_full | Surgical trends, outcomes and disparities in minimal invasive surgery for patients with endometrial cancer in England: a retrospective cohort study |
| title_fullStr | Surgical trends, outcomes and disparities in minimal invasive surgery for patients with endometrial cancer in England: a retrospective cohort study |
| title_full_unstemmed | Surgical trends, outcomes and disparities in minimal invasive surgery for patients with endometrial cancer in England: a retrospective cohort study |
| title_short | Surgical trends, outcomes and disparities in minimal invasive surgery for patients with endometrial cancer in England: a retrospective cohort study |
| title_sort | surgical trends outcomes and disparities in minimal invasive surgery for patients with endometrial cancer in england a retrospective cohort study |
| url | https://bmjopen.bmj.com/content/10/9/e036222.full |
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