CD32B1, a versatile non-signaling antibody-binding scaffold for enhanced T cell adhesion to tumor stromal cognate antigens

CD32B1, a versatile non-signaling antibody-binding scaffold for enhanced T cell adhesion to tumor stromal cognate antigens

Targeting cytotoxic T lymphocytes (CTLs), as chimeric antigen T cells (CAR-T), T cell receptor-engineered (TCR)-T cells or adoptive cell transfer of tumor infiltrating T cells (TILs) to solid tumors is a major therapeutic challenge. We describe a new strategy to confer these lymphocytes with de novo...

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Bibliographic Details
Main Authors: Sara W. Feigelson, Tali Dadosh, Nehora Levi, Anita Sapoznikov, Hadas Weinstein-Marom, Dayana Blokon-Kogan, Yahel Avraham, Tamar Unger, Gideon Gross, Rony Dahan, Ronen Alon
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Immunology
Subjects:
cancer immunotherapy
tumor microenvironment
cytotoxic lymphocytes
adoptive cell therapy
Fc receptors
microvilli
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1398757/full
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