Intracavitary adoptive transfer of IL-12 mRNA-engineered tumor-specific CD8+ T cells eradicates peritoneal metastases in mouse models

Intracavitary adoptive transfer of IL-12 mRNA-engineered tumor-specific CD8+ T cells eradicates peritoneal metastases in mouse models

Previous studies have shown that local delivery of tumor antigen-specific CD8+ T lymphocytes engineered to transiently express single-chain IL-12 mRNA is highly efficacious. Peritoneal dissemination of cancer is a frequent and often fatal patient condition usually diagnosed when the tumor burden is...

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Bibliographic Details
Main Authors: Claudia Augusta Di Trani, Assunta Cirella, Leire Arrizabalaga, Ángela Bella, Myriam Fernandez-Sendin, Joan Salvador Russo-Cabrera, Celia Gomar, Irene Olivera, Elizabeth Bolaños, José González-Gomariz, Maite Álvarez, Iñaki Etxeberria, Belen Palencia, Álvaro Teijeira, Ignacio Melero, Pedro Berraondo, Fernando Aranda
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:OncoImmunology
Subjects:
Peritoneal carcinomatosis
interleukin 12
adoptive cell transfer
mRNA
locoregional treatment
Online Access:https://www.tandfonline.com/doi/10.1080/2162402X.2022.2147317
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