O-GlcNAc transferase plays dual antiviral roles by integrating innate immunity and lipid metabolism

O-GlcNAc transferase plays dual antiviral roles by integrating innate immunity and lipid metabolism

Abstract Viral infection induces robust reprogramming of metabolic pathways in host cells. However, whether host metabolic enzymes detect viral components remains unknown. Our group and others previously identified O-GlcNAc transferase (OGT), an important glucose metabolic enzyme, as a crucial media...

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Main Authors: Hong Dong, Chenxi Liang, Junjie Zhang, Weidong Wu, Nitesh Kumar, Zihao Liu, Yajun Sun, Zhiwei Liao, Xiaolin Cheng, Yanbao Yu, Yong Zhang, Michael J. Holtzman, Jianrong Li, Kymberly M. Gowdy, Paul G. Thomas, Jovica D. Badjic, Anjun Ma, Qin Ma, Jacob S. Yount, Shan-Lu Liu, Haitao Wen
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-63085-y
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