Role of immunosuppression in an antibiotic stewardship intervention and its association with clinical outcomes and antibiotic use: protocol for an observational study (RISC-sepsis)

Role of immunosuppression in an antibiotic stewardship intervention and its association with clinical outcomes and antibiotic use: protocol for an observational study (RISC-sepsis)

Introduction Sepsis is characterised by a dysregulated immune response to infection, with exaggerated pro-inflammatory and anti-inflammatory responses. A predominant immunosuppressive profile affecting both innate and adaptive immune responses is associated with increased hospital-acquired infection...

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Main Authors: A John Simpson, Paul Dark, Katie Booth, Ranjit Lall, Gavin Perkins, Timothy Walsh, Manu Shankar-Hari, David McDonald, Daniel F McAuley, Andrew Conway Morris, Andrew Filby, Ronan McMullan, Thomas P Hellyer, Jonathan Scott, Loredana Trevi, Hannah McNeil, Tom Ewen, Phil Mawson, Gert Boschman, Vesna Melkebeek, Iain J McCullagh, Anthony Rostron
Format: Article
Language:English
Published: BMJ Publishing Group 2022-12-01
Series:BMJ Open
Online Access:https://bmjopen.bmj.com/content/12/12/e068321.full
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