Mitigating the global spread of multidrug-resistant Acinetobacter buamanni in Immunocompromised Patients
Abstract Acinetobacter baumannii has emerged as a critical global health threat due to its multidrug-resistant (MDR) nature, posing significant challenges in healthcare settings. This opportunistic pathogen is a common cause of hospital-acquired infections, including bloodstream infections, ventilat...
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| Format: | Article |
| Language: | English |
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Springer
2025-02-01
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| Series: | Discover Public Health |
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| Online Access: | https://doi.org/10.1186/s12982-025-00451-7 |
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| author | Maria Qadri Hira Tariq Muhammad Shahid Mehmood Muhammad Nabeel Saddique Waseem Sajjad |
| author_facet | Maria Qadri Hira Tariq Muhammad Shahid Mehmood Muhammad Nabeel Saddique Waseem Sajjad |
| author_sort | Maria Qadri |
| collection | DOAJ |
| description | Abstract Acinetobacter baumannii has emerged as a critical global health threat due to its multidrug-resistant (MDR) nature, posing significant challenges in healthcare settings. This opportunistic pathogen is a common cause of hospital-acquired infections, including bloodstream infections, ventilator-associated pneumonia (VAP), and surgical site infections, particularly in immunocompromised patients. The rising prevalence of colistin-resistant A. baumannii has intensified concerns as colistin is often considered a last-line therapy. Recent data indicate an increase in A. baumannii prevalence, with highest rates reported in South America, Lebanon, and China, and notable increases in Southeast Asia and the Eastern Mediterranean. Limited laboratory capacity, inconsistent reporting, and restricted surveillance capabilities exacerbate the spread of resistance, underscoring the need for standardized reporting guidelines and improved inter-hospital networks for data sharing. Enhanced training for healthcare professionals, improved diagnostic techniques, and robust infection control measures, including resistance-based hygiene protocols, are essential steps to contain this threat. This review emphasizes the urgent need for coordinated global efforts to strengthen antimicrobial stewardship and develop comprehensive policies to combat MDR A. baumannii and preserve the efficacy of last-line antibiotics. |
| format | Article |
| id | doaj-art-798d12f1da594a159a8f74ee5749d1f7 |
| institution | OA Journals |
| issn | 3005-0774 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Public Health |
| spelling | doaj-art-798d12f1da594a159a8f74ee5749d1f72025-08-20T02:15:06ZengSpringerDiscover Public Health3005-07742025-02-012211410.1186/s12982-025-00451-7Mitigating the global spread of multidrug-resistant Acinetobacter buamanni in Immunocompromised PatientsMaria Qadri0Hira Tariq1Muhammad Shahid Mehmood2Muhammad Nabeel Saddique3Waseem Sajjad4Jinnah Sindh Medical UniversityUniversity of PunjabUniversity of AgricultureKing Edward Medical University, KEMU Boys HostelKing Edward Medical University, KEMU Boys HostelAbstract Acinetobacter baumannii has emerged as a critical global health threat due to its multidrug-resistant (MDR) nature, posing significant challenges in healthcare settings. This opportunistic pathogen is a common cause of hospital-acquired infections, including bloodstream infections, ventilator-associated pneumonia (VAP), and surgical site infections, particularly in immunocompromised patients. The rising prevalence of colistin-resistant A. baumannii has intensified concerns as colistin is often considered a last-line therapy. Recent data indicate an increase in A. baumannii prevalence, with highest rates reported in South America, Lebanon, and China, and notable increases in Southeast Asia and the Eastern Mediterranean. Limited laboratory capacity, inconsistent reporting, and restricted surveillance capabilities exacerbate the spread of resistance, underscoring the need for standardized reporting guidelines and improved inter-hospital networks for data sharing. Enhanced training for healthcare professionals, improved diagnostic techniques, and robust infection control measures, including resistance-based hygiene protocols, are essential steps to contain this threat. This review emphasizes the urgent need for coordinated global efforts to strengthen antimicrobial stewardship and develop comprehensive policies to combat MDR A. baumannii and preserve the efficacy of last-line antibiotics.https://doi.org/10.1186/s12982-025-00451-7Acinetobacter baumanniiMultidrug resistanceAntibioticsGlobal healthAntimicrobial stewardship |
| spellingShingle | Maria Qadri Hira Tariq Muhammad Shahid Mehmood Muhammad Nabeel Saddique Waseem Sajjad Mitigating the global spread of multidrug-resistant Acinetobacter buamanni in Immunocompromised Patients Discover Public Health Acinetobacter baumannii Multidrug resistance Antibiotics Global health Antimicrobial stewardship |
| title | Mitigating the global spread of multidrug-resistant Acinetobacter buamanni in Immunocompromised Patients |
| title_full | Mitigating the global spread of multidrug-resistant Acinetobacter buamanni in Immunocompromised Patients |
| title_fullStr | Mitigating the global spread of multidrug-resistant Acinetobacter buamanni in Immunocompromised Patients |
| title_full_unstemmed | Mitigating the global spread of multidrug-resistant Acinetobacter buamanni in Immunocompromised Patients |
| title_short | Mitigating the global spread of multidrug-resistant Acinetobacter buamanni in Immunocompromised Patients |
| title_sort | mitigating the global spread of multidrug resistant acinetobacter buamanni in immunocompromised patients |
| topic | Acinetobacter baumannii Multidrug resistance Antibiotics Global health Antimicrobial stewardship |
| url | https://doi.org/10.1186/s12982-025-00451-7 |
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