Entorhinal transformations in abstract frames of reference.
Knowing how another's preferences relate to our own is a central aspect of everyday decision-making, yet how the brain performs this transformation is unclear. Here, we ask whether the putative role of the hippocampal-entorhinal system in transforming relative and absolute spatial coordinates d...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2019-05-01
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| Series: | PLoS Biology |
| Online Access: | https://doi.org/10.1371/journal.pbio.3000230 |
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| _version_ | 1850186410711056384 |
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| author | Raphael Kaplan Karl J Friston |
| author_facet | Raphael Kaplan Karl J Friston |
| author_sort | Raphael Kaplan |
| collection | DOAJ |
| description | Knowing how another's preferences relate to our own is a central aspect of everyday decision-making, yet how the brain performs this transformation is unclear. Here, we ask whether the putative role of the hippocampal-entorhinal system in transforming relative and absolute spatial coordinates during navigation extends to transformations in abstract decision spaces. During functional magnetic resonance imaging (fMRI), subjects learned a stranger's preference for an everyday activity-relative to one of three personally known individuals-and subsequently decided how the stranger's preference relates to the other two individuals' preferences. We observed entorhinal/subicular responses to the absolute distance between the ratings of the stranger and the familiar choice options. Notably, entorhinal/subicular signals were sensitive to which familiar individuals were being compared to the stranger. In contrast, striatal signals increased when accurately determining the ordinal position of choice options in relation to the stranger. Paralleling its role in navigation, these data implicate the entorhinal/subicular region in assimilating relatively coded knowledge within abstract metric spaces. |
| format | Article |
| id | doaj-art-798cc6185a70451093bb71b0d8df9942 |
| institution | OA Journals |
| issn | 1544-9173 1545-7885 |
| language | English |
| publishDate | 2019-05-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Biology |
| spelling | doaj-art-798cc6185a70451093bb71b0d8df99422025-08-20T02:16:21ZengPublic Library of Science (PLoS)PLoS Biology1544-91731545-78852019-05-01175e300023010.1371/journal.pbio.3000230Entorhinal transformations in abstract frames of reference.Raphael KaplanKarl J FristonKnowing how another's preferences relate to our own is a central aspect of everyday decision-making, yet how the brain performs this transformation is unclear. Here, we ask whether the putative role of the hippocampal-entorhinal system in transforming relative and absolute spatial coordinates during navigation extends to transformations in abstract decision spaces. During functional magnetic resonance imaging (fMRI), subjects learned a stranger's preference for an everyday activity-relative to one of three personally known individuals-and subsequently decided how the stranger's preference relates to the other two individuals' preferences. We observed entorhinal/subicular responses to the absolute distance between the ratings of the stranger and the familiar choice options. Notably, entorhinal/subicular signals were sensitive to which familiar individuals were being compared to the stranger. In contrast, striatal signals increased when accurately determining the ordinal position of choice options in relation to the stranger. Paralleling its role in navigation, these data implicate the entorhinal/subicular region in assimilating relatively coded knowledge within abstract metric spaces.https://doi.org/10.1371/journal.pbio.3000230 |
| spellingShingle | Raphael Kaplan Karl J Friston Entorhinal transformations in abstract frames of reference. PLoS Biology |
| title | Entorhinal transformations in abstract frames of reference. |
| title_full | Entorhinal transformations in abstract frames of reference. |
| title_fullStr | Entorhinal transformations in abstract frames of reference. |
| title_full_unstemmed | Entorhinal transformations in abstract frames of reference. |
| title_short | Entorhinal transformations in abstract frames of reference. |
| title_sort | entorhinal transformations in abstract frames of reference |
| url | https://doi.org/10.1371/journal.pbio.3000230 |
| work_keys_str_mv | AT raphaelkaplan entorhinaltransformationsinabstractframesofreference AT karljfriston entorhinaltransformationsinabstractframesofreference |