K18-hACE2 mice develop respiratory disease resembling severe COVID-19.

K18-hACE2 mice develop respiratory disease resembling severe COVID-19.

SARS-CoV-2 emerged in late 2019 and resulted in the ongoing COVID-19 pandemic. Several animal models have been rapidly developed that recapitulate the asymptomatic to moderate disease spectrum. Now, there is a direct need for additional small animal models to study the pathogenesis of severe COVID-1...

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Main Authors: Claude Kwe Yinda, Julia R Port, Trenton Bushmaker, Irene Offei Owusu, Jyothi N Purushotham, Victoria A Avanzato, Robert J Fischer, Jonathan E Schulz, Myndi G Holbrook, Madison J Hebner, Rebecca Rosenke, Tina Thomas, Andrea Marzi, Sonja M Best, Emmie de Wit, Carl Shaia, Neeltje van Doremalen, Vincent J Munster
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-01-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1009195
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