Domoic Acid: A Review of Its Cytogenotoxicity Within the One Health Approach
In this review, we toxicologically assessed the naturally occurring toxin domoic acid. We used the One Health approach because the impact of domoic acid is potentiated by climate change and water pollution on one side, and reflected in animal health, food security, human diet, and human health on th...
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| Language: | English |
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MDPI AG
2024-11-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/13/11/1366 |
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| author | Goran Gajski Marko Gerić Ana Baričević Mirta Smodlaka Tanković |
| author_facet | Goran Gajski Marko Gerić Ana Baričević Mirta Smodlaka Tanković |
| author_sort | Goran Gajski |
| collection | DOAJ |
| description | In this review, we toxicologically assessed the naturally occurring toxin domoic acid. We used the One Health approach because the impact of domoic acid is potentiated by climate change and water pollution on one side, and reflected in animal health, food security, human diet, and human health on the other. In a changing environment, algal blooms are more frequent. For domoic acid production, the growth of <i>Pseudo-nitzschia</i> diatoms is of particular interest. They produce this toxin, whose capability of accumulation and biomagnification through the food web impacts other organisms in the ecosystem. Domoic acid targets nervous system receptors inducing amnestic shellfish poisoning, among other less severe health-related problems. However, the impact of domoic acid on non-target cells is rather unknown, so we reviewed the currently available literature on cytogenetic effects on human and animal cells. The results of different studies indicate that domoic acid has the potential to induce early molecular events, such as oxidative imbalance and DNA damage, thus posing an additional threat which needs to be thoroughly addressed and monitored in the future. |
| format | Article |
| id | doaj-art-7988955afae2414282f1bbf48a5cdd0e |
| institution | OA Journals |
| issn | 2076-3921 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj-art-7988955afae2414282f1bbf48a5cdd0e2025-08-20T01:53:52ZengMDPI AGAntioxidants2076-39212024-11-011311136610.3390/antiox13111366Domoic Acid: A Review of Its Cytogenotoxicity Within the One Health ApproachGoran Gajski0Marko Gerić1Ana Baričević2Mirta Smodlaka Tanković3Division of Toxicology, Institute for Medical Research and Occupational Health, 10000 Zagreb, CroatiaDivision of Toxicology, Institute for Medical Research and Occupational Health, 10000 Zagreb, CroatiaCenter for Marine Research, Ruđer Bošković Institute, 52210 Rovinj, CroatiaCenter for Marine Research, Ruđer Bošković Institute, 52210 Rovinj, CroatiaIn this review, we toxicologically assessed the naturally occurring toxin domoic acid. We used the One Health approach because the impact of domoic acid is potentiated by climate change and water pollution on one side, and reflected in animal health, food security, human diet, and human health on the other. In a changing environment, algal blooms are more frequent. For domoic acid production, the growth of <i>Pseudo-nitzschia</i> diatoms is of particular interest. They produce this toxin, whose capability of accumulation and biomagnification through the food web impacts other organisms in the ecosystem. Domoic acid targets nervous system receptors inducing amnestic shellfish poisoning, among other less severe health-related problems. However, the impact of domoic acid on non-target cells is rather unknown, so we reviewed the currently available literature on cytogenetic effects on human and animal cells. The results of different studies indicate that domoic acid has the potential to induce early molecular events, such as oxidative imbalance and DNA damage, thus posing an additional threat which needs to be thoroughly addressed and monitored in the future.https://www.mdpi.com/2076-3921/13/11/1366domoic acidmarine biotoxin<i>Pseudo-nitzschia</i>non-target cellscytotoxicitygenotoxicity |
| spellingShingle | Goran Gajski Marko Gerić Ana Baričević Mirta Smodlaka Tanković Domoic Acid: A Review of Its Cytogenotoxicity Within the One Health Approach Antioxidants domoic acid marine biotoxin <i>Pseudo-nitzschia</i> non-target cells cytotoxicity genotoxicity |
| title | Domoic Acid: A Review of Its Cytogenotoxicity Within the One Health Approach |
| title_full | Domoic Acid: A Review of Its Cytogenotoxicity Within the One Health Approach |
| title_fullStr | Domoic Acid: A Review of Its Cytogenotoxicity Within the One Health Approach |
| title_full_unstemmed | Domoic Acid: A Review of Its Cytogenotoxicity Within the One Health Approach |
| title_short | Domoic Acid: A Review of Its Cytogenotoxicity Within the One Health Approach |
| title_sort | domoic acid a review of its cytogenotoxicity within the one health approach |
| topic | domoic acid marine biotoxin <i>Pseudo-nitzschia</i> non-target cells cytotoxicity genotoxicity |
| url | https://www.mdpi.com/2076-3921/13/11/1366 |
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