Pathogenicity and virulence of Helicobacter pylori: A paradigm of chronic infection
Infection with Helicobacter pylori is one of the most common infections of mankind. Infection typically occurs in childhood and persists for the lifetime of the host unless eradicated with antimicrobials. The organism colonizes the stomach and causes gastritis. Most infected individuals are asymptom...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Virulence |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/21505594.2024.2438735 |
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| _version_ | 1846106860606717952 |
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| author | Marguerite Clyne Tadhg Ó Cróinín |
| author_facet | Marguerite Clyne Tadhg Ó Cróinín |
| author_sort | Marguerite Clyne |
| collection | DOAJ |
| description | Infection with Helicobacter pylori is one of the most common infections of mankind. Infection typically occurs in childhood and persists for the lifetime of the host unless eradicated with antimicrobials. The organism colonizes the stomach and causes gastritis. Most infected individuals are asymptomatic, but infection also causes gastric and duodenal ulceration, and gastric cancer. H. pylori possesses an arsenal of virulence factors, including a potent urease enzyme for protection from acid, flagella that mediate motility, an abundance of outer membrane proteins that can mediate attachment, several immunomodulatory proteins, and an ability to adapt to specific conditions in individual human stomachs. The presence of a type 4 secretion system that injects effector molecules into gastric cells and subverts host cell signalling is associated with virulence. In this review we discuss the interplay of H. pylori colonization and virulence factors with host and environmental factors to determine disease outcome in infected individuals. |
| format | Article |
| id | doaj-art-7983a9617514417cb47c1decdac8aef0 |
| institution | Kabale University |
| issn | 2150-5594 2150-5608 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Virulence |
| spelling | doaj-art-7983a9617514417cb47c1decdac8aef02024-12-27T04:16:40ZengTaylor & Francis GroupVirulence2150-55942150-56082025-12-0116110.1080/21505594.2024.2438735Pathogenicity and virulence of Helicobacter pylori: A paradigm of chronic infectionMarguerite Clyne0Tadhg Ó Cróinín1School of Medicine, University College Dublin, Dublin, IrelandThe Conway Institute of Biomolecular and Biomedical Science, University College Dublin, Dublin, IrelandInfection with Helicobacter pylori is one of the most common infections of mankind. Infection typically occurs in childhood and persists for the lifetime of the host unless eradicated with antimicrobials. The organism colonizes the stomach and causes gastritis. Most infected individuals are asymptomatic, but infection also causes gastric and duodenal ulceration, and gastric cancer. H. pylori possesses an arsenal of virulence factors, including a potent urease enzyme for protection from acid, flagella that mediate motility, an abundance of outer membrane proteins that can mediate attachment, several immunomodulatory proteins, and an ability to adapt to specific conditions in individual human stomachs. The presence of a type 4 secretion system that injects effector molecules into gastric cells and subverts host cell signalling is associated with virulence. In this review we discuss the interplay of H. pylori colonization and virulence factors with host and environmental factors to determine disease outcome in infected individuals.https://www.tandfonline.com/doi/10.1080/21505594.2024.2438735Helicobacter pylorivirulencegastritisduodenal ulcergastric cancerepidemiology |
| spellingShingle | Marguerite Clyne Tadhg Ó Cróinín Pathogenicity and virulence of Helicobacter pylori: A paradigm of chronic infection Virulence Helicobacter pylori virulence gastritis duodenal ulcer gastric cancer epidemiology |
| title | Pathogenicity and virulence of Helicobacter pylori: A paradigm of chronic infection |
| title_full | Pathogenicity and virulence of Helicobacter pylori: A paradigm of chronic infection |
| title_fullStr | Pathogenicity and virulence of Helicobacter pylori: A paradigm of chronic infection |
| title_full_unstemmed | Pathogenicity and virulence of Helicobacter pylori: A paradigm of chronic infection |
| title_short | Pathogenicity and virulence of Helicobacter pylori: A paradigm of chronic infection |
| title_sort | pathogenicity and virulence of helicobacter pylori a paradigm of chronic infection |
| topic | Helicobacter pylori virulence gastritis duodenal ulcer gastric cancer epidemiology |
| url | https://www.tandfonline.com/doi/10.1080/21505594.2024.2438735 |
| work_keys_str_mv | AT margueriteclyne pathogenicityandvirulenceofhelicobacterpyloriaparadigmofchronicinfection AT tadhgocroinin pathogenicityandvirulenceofhelicobacterpyloriaparadigmofchronicinfection |