C-type natriuretic peptide attenuates enhanced glycolysis and de novo pyrimidine synthesis in pericytes of patients with pulmonary arterial hypertension

C-type natriuretic peptide attenuates enhanced glycolysis and de novo pyrimidine synthesis in pericytes of patients with pulmonary arterial hypertension

Abstract Metabolic reprogramming of vascular cells plays a crucial role in Pulmonary Arterial Hypertension (PAH), marked by a shift from oxidative phosphorylation to glycolysis (Warburg effect), altered purine biosynthesis, impaired glutaminolysis and fatty acid oxidation, driving endothelial and sm...

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Main Authors: Minhee Noh, Ankita Mitra, Lisa Krebes, Werner Schmitz, Jan Dudek, Stuti Agarwal, Christoph Maack, Paula Arias-Loza, Takahiro Higuchi, Ivan Aleksic, Vinicio A. de Jesus Perez, Michaela Kuhn, Swati Dabral
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-08661-0
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