Association between phthalates exposure and urine flow rate
Abstract This study aimed to examine the association between phthalate exposure and urine flow rate (UFR). Data from 6951 adult participants across five consecutive NHANES cycles (2009–2018) were analyzed. High-performance liquid chromatography–electrospray ionization tandem mass spectrometry was us...
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Nature Portfolio
2025-07-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-09080-1 |
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| author | Shuai Zhang Hanhan Tang Minglian Zhou |
| author_facet | Shuai Zhang Hanhan Tang Minglian Zhou |
| author_sort | Shuai Zhang |
| collection | DOAJ |
| description | Abstract This study aimed to examine the association between phthalate exposure and urine flow rate (UFR). Data from 6951 adult participants across five consecutive NHANES cycles (2009–2018) were analyzed. High-performance liquid chromatography–electrospray ionization tandem mass spectrometry was used to measure urinary concentrations of 10 highly detectable phthalate metabolites (PMs). Associations between PMs and UFR were investigated using various analytical approaches, including weighted linear regression, weighted quantile sum regression (WQS), quantile g-computation (qgcomp), restricted cubic spline (RCS), and Bayesian kernel-machine regression (BKMR) models. Each quartile increase in the WQS index for PM mixtures was associated with a − 0.042 lower ln-transformed UFR (95% CI − 0.07, − 0.014). The qgcomp regression model yielded consistent results. In BKMR analysis, PM mixtures showed a significant negative association with ln-transformed UFR, with mono-2-ethyl-5-carboxypentyl phthalate (MECPP) and mono-benzyl phthalate (MBzP) identified as potential key contributors. In addition, the RCS results showed an inverted s-type nonlinear relationship between MECPP and MBzP, and UFR. Exposure to phthalates is associated with lower UFR. |
| format | Article |
| id | doaj-art-797fa744bc954db6981932d9808e201f |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-797fa744bc954db6981932d9808e201f2025-08-20T03:46:04ZengNature PortfolioScientific Reports2045-23222025-07-0115111010.1038/s41598-025-09080-1Association between phthalates exposure and urine flow rateShuai Zhang0Hanhan Tang1Minglian Zhou2Department of Male Reproductive Health, Lianyungang Maternal and Child Health HospitalDepartment of Plastic Surgery, Xuzhou Central HospitalDepartment of Male Reproductive Health, Lianyungang Maternal and Child Health HospitalAbstract This study aimed to examine the association between phthalate exposure and urine flow rate (UFR). Data from 6951 adult participants across five consecutive NHANES cycles (2009–2018) were analyzed. High-performance liquid chromatography–electrospray ionization tandem mass spectrometry was used to measure urinary concentrations of 10 highly detectable phthalate metabolites (PMs). Associations between PMs and UFR were investigated using various analytical approaches, including weighted linear regression, weighted quantile sum regression (WQS), quantile g-computation (qgcomp), restricted cubic spline (RCS), and Bayesian kernel-machine regression (BKMR) models. Each quartile increase in the WQS index for PM mixtures was associated with a − 0.042 lower ln-transformed UFR (95% CI − 0.07, − 0.014). The qgcomp regression model yielded consistent results. In BKMR analysis, PM mixtures showed a significant negative association with ln-transformed UFR, with mono-2-ethyl-5-carboxypentyl phthalate (MECPP) and mono-benzyl phthalate (MBzP) identified as potential key contributors. In addition, the RCS results showed an inverted s-type nonlinear relationship between MECPP and MBzP, and UFR. Exposure to phthalates is associated with lower UFR.https://doi.org/10.1038/s41598-025-09080-1PhthalatesUrine flow rateMixture analysisNHANES |
| spellingShingle | Shuai Zhang Hanhan Tang Minglian Zhou Association between phthalates exposure and urine flow rate Scientific Reports Phthalates Urine flow rate Mixture analysis NHANES |
| title | Association between phthalates exposure and urine flow rate |
| title_full | Association between phthalates exposure and urine flow rate |
| title_fullStr | Association between phthalates exposure and urine flow rate |
| title_full_unstemmed | Association between phthalates exposure and urine flow rate |
| title_short | Association between phthalates exposure and urine flow rate |
| title_sort | association between phthalates exposure and urine flow rate |
| topic | Phthalates Urine flow rate Mixture analysis NHANES |
| url | https://doi.org/10.1038/s41598-025-09080-1 |
| work_keys_str_mv | AT shuaizhang associationbetweenphthalatesexposureandurineflowrate AT hanhantang associationbetweenphthalatesexposureandurineflowrate AT minglianzhou associationbetweenphthalatesexposureandurineflowrate |